ListarPSB_Articles por tema "Genètica"
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Drosophila Muscleblind Is Involved in troponin T Alternative Splicing and Apoptosis
Public Library of Science (PLoS) (2008)Background: Muscleblind-like proteins (MBNL) have been involved in a developmental switch in the use of defined cassette exons. Such transition fails in the CTG repeat expansion disease myotonic dystrophy due, in part, ... -
Genetic and Chemical Modifiers Of A CUG Toxicity Model in Drosophila
Public Library of Science (PLoS) (2008)Non-coding CUG repeat expansions interfere with the activity of human Muscleblind-like (MBNL) proteins contributing to myotonic dystrophy 1 (DM1). To understand this toxic RNA gain-of-function mechanism we developed a ...