Listar PSB_Articles por autoría "b7c2de09-e39c-4c62-ac45-ce9ac61ef947"
Mostrando ítems 1-10 de 10
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Behavioral and dopamine transporter binding properties of the modafinil analog (S, S)-CE-158: reversal of the motivational effects of tetrabenazine and enhancement of progressive ratio responding
Rotolo, Renee; Kalaba, Predrag; Dragacevic, Vladimir; Presby, Rose; Neri, Julia; Robertson, Emily; Yang, Jen-Hau; Correa, Merce; Bakulev, Vasiliy; Volkova, Natalia N.; Pifl, Christian; Lubec, Gert; Salamone, John Springer (2020)Rationale Atypical dopamine (DA) transport blockers such as modafinil and its analogs may be useful for treating motivational symptoms of depression and other disorders. Previous research has shown that the DA depleting ... -
Complexities and paradoxes in understanding the role of dopamine in incentive motivation and instrumental action: Exertion of effort vs. anhedonia
Salamone, John; Ecevitoglu, Alev; Carratalá-Ros, Carla; Presby, Rose; Edelstein, Gayle A; Fleeher, Reileigh; Rotolo, Renee; Meka, Nicolette; Srinath, Sonya; Masthay, Jamie C.; Correa, Merce Elsevier (2022-05)Instrumental behavior is a very complex and multifaceted process. Behavioral output during instrumental performance is influenced by a variety of factors, including associative conditioning, directional and activational ... -
Dopamine, Effort-Based Choice, and Behavioral Economics: Basic and Translational Research
Salamone, John; Correa, Merce; Yang, Jen-Hau; Rotolo, Renee; Presby, Rose Frontiers Media (2018-03)Operant behavior is not only regulated by factors related to the quality or quantity of reinforcement, but also by the work requirements inherent in performing instrumental actions. Moreover, organisms often make ... -
Effects of the dopamine depleting agent tetrabenazine on detailed temporal parameters of effort-related choice responding
Ren, Naxin; Carratalá-Ros, Carla; Ecevitoglu, Alev; Rotolo, Renee; Edelstein, Gayle A; Presby, Rose; Stevenson, Ian; Chrobak, James; Salamone, John Society for the Experimental Analysis of Behavior (2022-03-28)The dopamine-depleting agent tetrabenazine alters effort-based choice, suppressing food-reinforced behaviors with high response requirements, while increasing selection of low-cost options. In the present experiments, rats ... -
Effort-related decision making in humanized COMT mice: Effects ofVal158Met polymorphisms and possible implications for negative symptomsin humans
Yang, Jen-Hau; Presby, Rose; Cayer, Suzanne; Rotolo, Renee; Perrino, Peter A.; Fitch, R. Holly; Correa, Merce; Chesler, Elissa J.; Salamone, John Elsevier (2020)Catechol-o-methyltransferase (COMT) is an enzyme that metabolizes catecholamines, and is crucial for clearanceof dopamine (DA) in prefrontal cortex. Val158Met polymorphism, which causes a valine (Val) to methionine(Met) ... -
Lisdexamfetamine suppresses instrumental and consummatory behaviorssupported by foods with varying degrees of palatability: Exploration of abinge-like eating model
Presby, Rose; Rotolo, Renee; Yang, Jen-Hau; Correa, Merce; Salamone, John Elsevier (2020)Diets high in sugar or fat are associated with multiple health conditions, including binge eating disorder (BED). BED affects approximately 2% of the US adult population, and occurs more frequently in females. It is important ... -
Pharmacological studies of effort-related decision making using mouse touchscreen procedures: effects of dopamine antagonism do not resemble reinforcer devaluation by removal of food restriction
Yang, Jen-Hau; Presby, Rose; Jarvie, Adam A.; Rotolo, Renee; Fitch, R. Holly; Correa, Merce; Salamone, John Springer Verlag (2020)Rationale Effort-based decision-making tasks offer animals choices between preferred reinforcers that require high effort to obtain vs. low effort/low reward options. The neural mechanisms of effort-based choice are widely ... -
Sex differences in lever pressing and running wheel tasks of effort-based choice behavior in rats: Suppression of high effort activity by the serotonin transport inhibitor fluoxetine
Presby, Rose; Rotolo, Renee; Hurley, Erin M.; Ferrigno, Sarah M.; Murphy, Cayla; McMullen, Haley P.; Desai, Pranally A.; Zorda, Emma; Kuperwasser, Felicita B.; Carratalá-Ros, Carla; Correa, Merce; Salamone, John Elsevier (2021)Selective serotonin transport (SERT) inhibitors such as fluoxetine are the most commonly prescribed treatments for depression. Although efficacious for many symptoms of depression, motivational impairments such as psychomotor ... -
The dopamine depleting agent tetrabenazine alters effort-related decision making as assessed by mouse touchscreen procedures
Yang, Jen-Hau; Presby, Rose; Rotolo, Renee; Quiles, Taina; Okifo, Kevin; Zorda, Emma; Fitch, R. Holly; Correa, Merce; Salamone, John Springer (2020)Rationale Effort-based decision-making tasks allow animals to choose between preferred reinforcers that require high effort to obtain vs. low-effort/low reward options. Mesolimbic dopamine (DA) and related neural systems ... -
The Novel Atypical Dopamine Uptake Inhibitor (S)-CE-123 Partially Reverses the Effort-Related Effects of the Dopamine Depleting Agent Tetrabenazine and Increases Progressive Ratio Responding
Rotolo, Renee; Dragacevic, Vladimir; Kalaba, Predrag; Urban, Ernst; Zehl, Martin; Roller, Alexander; Wackerlig, Judith; Langer, Thierry; Pistis, Marco; De Luca, Maria Antonietta; Caria, Francesca; Schwartz, Rebecca; Presby, Rose; Yang, Jen-Hau; Samels, Shanna; Correa, Merce; Lubec, Gert; Salamone, John Frontiers Media (2019-06-28)Animal studies of effort-based choice behavior are being used to model effort-related motivational dysfunctions in humans. With these procedures, animals are offered a choice between high-effort instrumental actions ...