Listar PSB_Articles por autoría "9fce0b0f-383f-4840-9777-872cbfe38761"
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A Novel and Selective Dopamine Transporter Inhibitor, (S)-MK-26, Promotes Hippocampal Synaptic Plasticity and Restores Effort-Related Motivational Dysfunctions
Kouhnavardi, Shima; Ecevitoglu, Alev; Dragačević, Vladimir; Sanna, Fabrizio; Arias-Sandoval, Edgar; Kalaba, Predrag; Kirchhofer, Michael; Lubec, Jana; Niello, Marco; Holy, Marion; Zehl, Martin; Pillwein, Matthias; Wackerlig, Judith; Murau, Rita; Mohrmann, Andrea; Beard, Kathryn R.; Sitte, Harald; Urban, Ernst; Sagheddu, Claudia; Pistis, Marco; Plasenzotti, Roberto; Salamone, John; Langer, Thierry; Lubec, Gert; Monje, Francisco J. MDPI (2022-07)Dopamine (DA), the most abundant human brain catecholaminergic neurotransmitter, modulates key behavioral and neurological processes in young and senescent brains, including motricity, sleep, attention, emotion, learning ... -
Acetate as an active metabolite of ethanol: studies of locomotion, loss of righting reflex, and anxiety in rodents
Pardo Andrés, Marta; Betz, Adrienne J.; San Miguel Segura, Noemí; López Cruz, Laura; Salamone, John; Correa, Merce Frontiers (2013)It has been postulated that a number of the central effects of ethanol are mediated via ethanol metabolites: acetaldehyde and acetate. Ethanol is known to produce a large variety of behavioral actions such anxiolysis, ... -
Activational and effort-related aspects of motivation: neural mechanisms and implications for psychopathology
Salamone, John; Yohn, Samantha E.; López Cruz, Laura; San Miguel Segura, Noemí; Correa, Merce Oxford University Press (2016-04-26)Motivation has been defined as the process that allows organisms to regulate their internal and external environment, and control the probability, proximity and availability of stimuli. As such, motivation is a complex ... -
Adenosine A2A receptor antagonism and genetic deletion attenuate the effects of dopamine D2 antagonism on effort-based decision making in mice
Pardo Andrés, Marta; López Cruz, Laura; Valverde, Olga; LEDENT, Catherine; Baqi, Younis; Müller, Christa E.; Salamone, John; Correa, Merce Elsevier (2012)Brain dopamine (DA) and adenosine interact in the regulation of behavioral activation and effort-related processes. In the present studies, a T-maze task was developed in mice for the assessment of effort-related decision ... -
Adenosine A2A receptor deletion affects social behaviors and anxiety in mice: Involvement of anterior cingulate cortex and amygdala
López Cruz, Laura; Carbó Gas, María; Pardo, Marta; Bayarri Iturralde, Pilar; Valverde, Olga; LEDENT, Catherine; Salamone, John; Correa, Merce Elsevier (2017)Blockade of adenosine A2A receptors can potentiate motivation to work for natural reinforcers such as food. Conspecific interaction is a potent natural reinforcer in social animals that can be manifested as preference for ... -
Assessment of a glycine uptake inhibitor in animal models of effort-related choice behavior: implications for motivational dysfunctions
Yohn, Samantha E.; Alberati, Daniela; Correa, Merce; Salamone, John Springer Verlag (2017)Rationale Motivated behavior can be characterized by a substantial exertion of effort, and organisms often make effortrelated decisions based upon analyses of work-related response costs and reinforcement preference. ... -
Assessment of a glycine uptake inhibitor in animal models of effort-related choice behavior: implications for motivational dysfunctions
Yohn, Samantha E.; Alberati, Daniela; Correa, Merce; Salamone, John Springer Verlag (2017)Rationale Motivated behavior can be characterized by a substantial exertion of effort, and organisms often make effortrelated decisions based upon analyses of work-related response costs and reinforcement preference. ... -
Behavioral and dopamine transporter binding properties of the modafinil analog (S, S)-CE-158: reversal of the motivational effects of tetrabenazine and enhancement of progressive ratio responding
Rotolo, Renee; Kalaba, Predrag; Dragacevic, Vladimir; Presby, Rose; Neri, Julia; Robertson, Emily; Yang, Jen-Hau; Correa, Merce; Bakulev, Vasiliy; Volkova, Natalia N.; Pifl, Christian; Lubec, Gert; Salamone, John Springer (2020)Rationale Atypical dopamine (DA) transport blockers such as modafinil and its analogs may be useful for treating motivational symptoms of depression and other disorders. Previous research has shown that the DA depleting ... -
Blockade of uptake for dopamine, but not norepinephrine or 5-HT, increases selection of high effort instrumental activity: Implications for treatment of effort-related motivational symptoms in psychopathology
Yohn, Samantha E.; Errante, Emily E.; Rosenbloom Snow, Aaron; Somerville, Matthew; Rowland, Margaret; Tokarski, Kristin; Zafar, Nadia; Correa, Merce; Salamone, John Elsevier (2016)Deficits in behavioral activation, exertion of effort, and other psychomotor/motivational symptoms are frequently seen in people with depression and other disorders. Depressed people show a decision bias towards selection ... -
c-Fos immunoreactivity in prefrontal, basal ganglia and limbic areas of the rat brain after central and peripheral administration of ethanol and its metabolite acetaldehyde
Segovia, Kristen N.; Vontell, Regina; López Cruz, Laura; Salamone, John; Correa, Merce Frontiers (2013)Considerable evidence indicates that the metabolite of ethanol (EtOH), acetaldehyde, is biologically active. Acetaldehyde can be formed from EtOH peripherally mainly by alcohol dehydrogenase (ADH), and also centrally by ... -
Caffeine and Selective Adenosine Receptor Antagonists as New Therapeutic Tools for the Motivational Symptoms of Depression
López Cruz, Laura; Salamone, John; Correa, Merce Frontiers Media (2018-06-01)Major depressive disorder is one of the most common and debilitating psychiatric disorders. Some of the motivational symptoms of depression, such anergia (lack of self-reported energy) and fatigue are relatively resistant ... -
Caffeine Modulates Food Intake Depending on the Context That Gives Access to Food: Comparison With Dopamine Depletion
Correa, Merce; San Miguel Segura, Noemí; López Cruz, Laura; Carratalá-Ros, Carla; Olivares-García, Régulo; Salamone, John (2018-09-06)Caffeine is a methylxanthine consumed in different context s to potentiate alertness and reduce fatigue. However, caffeine can induce anxiety at hig h doses. Caffeine is also a minor psychostimulant that seems to act ... -
Changes in nucleus accumbens and neostriatal c-Fos and DARPP-32 immunoreactivity during different stages of food-reinforced instrumental training
Segovia, Kristen N.; Correa, Merce; Lennington, Jessica B.; Conover, Joanne C.; Salamone, John Blackwells Publishing (2012)Nucleus accumbens is involved in several aspects of instrumental behavior, motivation and learning. Recent studies showed that dopamine (DA) release in the accumbens shell was significantly increased on the first day of ... -
Choosing voluntary exercise over sucrose consumption depends upon dopamine transmission: effects of haloperidol in wild type and adenosine A2AKO mice
Correa, Merce; Pardo Andrés, Marta; Bayarri Iturralde, Pilar; López Cruz, Laura; San Miguel Segura, Noemí; Valverde, Olga; LEDENT, Catherine; Salamone, John Springer (2016-02)Rationale: Mesolimbic dopamine (DA) regulates behavioral activation and effort-related decision-making in motivated behaviors. Mesolimbic DA D2 receptors are co-localized with adenosine A2A receptors, and they interact in ... -
Complexities and paradoxes in understanding the role of dopamine in incentive motivation and instrumental action: Exertion of effort vs. anhedonia
Salamone, John; Ecevitoglu, Alev; Carratalá-Ros, Carla; Presby, Rose; Edelstein, Gayle A; Fleeher, Reileigh; Rotolo, Renee; Meka, Nicolette; Srinath, Sonya; Masthay, Jamie C.; Correa, Merce Elsevier (2022-05)Instrumental behavior is a very complex and multifaceted process. Behavioral output during instrumental performance is influenced by a variety of factors, including associative conditioning, directional and activational ... -
Conditional neural knockout of the adenosine A2A receptor and pharmacological A2A antagonism reduce pilocarpine-induced tremulous jaw movements: Studies with a mouse model of parkinsonian tremor
Salamone, John; Collins-Praino, Lyndsey E.; Pardo Andrés, Marta; Podurgiel, Samantha J.; Baqi, Younis; Müller, Christa E.; Schwarzschild, Michael A.; Correa, Merce Elsevier (2013)Tremulous jaw movements are rapid vertical deflections of the lower jaw that resemble chewing but are not directed at any particular stimulus. In rats, tremulous jaw movements can be induced by a number of conditions that ... -
Deterioros motores producidos por los antipsicóticos típicos en muestras de ratones adultos jóvenes y viejos: Efecto terapeútico de los antagonistas de adenosina cafeína, teofilina y MSX-3
López Cruz, Laura; Fuentes-Claramonte, Paola; Pardo, Marta; Caballer, Gemma; Salamone, John; Correa, Merce Universitat Jaume I (2008)Uno de los efectos colaterales de la administración de neurolépticos para el tratamiento de los síntomas de la esquizofrenia es la afectación motora. Los antagonistas dopaminérgicos como el haloperidol, ampliamente ... -
Differences between the nonselective adenosine receptor antagonists caffeine and theophylline in motor and mood effects: Studies using medium to high doses in animal models
López Cruz, Laura; Pardo Andrés, Marta; Salamone, John; Correa, Merce Elsevier (2014-08)Rationale: Caffeine and theophylline are methylxanthines that are broadly consumed, sometimes at high doses, and act as minor psychostimulants. Both are nonselective adenosine antagonists for A1 and A2A receptors, which ... -
Differential effects of selective adenosine antagonists on the effort-related impairments induced by dopamine D1 and D2 antagonism
Nunes, Eric J.; Randall, Patrick A.; Santerre, Jessica L.; Given, A. B.; Sager, Thomas Nikolaj; Correa, Merce; Salamone, John Elsevier (2010)Mesolimbic dopamine (DA) is a critical component of the brain circuitry regulating behavioral activation and effort-related processes. Rats with impaired DA transmission reallocate their instrumental behavior away from ... -
Dopamine and Food Addiction: Lexicon Badly Needed
Salamone, John; Correa, Merce Elsevier (2013-05-01)Over the last few years, the concept of food addiction has become a common feature in the scientific literature, as well as the popular press. Nevertheless, the use of the term addiction to describe pathological aspects ...