Listar PSB_Articles por autoría "9fce0b0f-383f-4840-9777-872cbfe38761"
Mostrando ítems 41-60 de 79
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Impact of Fluoxetine on Behavioral Invigoration of Appetitive and Aversively Motivated Responses: Interaction With Dopamine Depletion
Carratalá-Ros, Carla; López Cruz, Laura; Martínez Verdú, Andrea; Olivares-García, Régulo; Salamone, John; Correa, Merce Frontiers Media (2021)Impaired behavioral activation and effort-related motivational dysfunctions like fatigue and anergia are debilitating treatment-resistant symptoms of depression. Depressed people show a bias towards the selection of low ... -
Individual differences in the energizing effects of caff eine on effort-baseddecision-making tests in rats
SanMiguel, Noemí; Pardo, Marta; Carratalá-Ros, Carla; López Cruz, Laura; Salamone, John; Correa, Merce Elsevier (2018)Motivated behavior is characterized by activation and high work output. Nucleus accumbens (Nacb) modulates behavioral activation and effort-based decision-making. Caffeine is widely consumed because of its energizing ... -
Induction of oral tremor in mice by the acetylcholinesterase inhibitor galantamine: Reversal with adenosine A2A antagonism
Podurgiel, Samantha J.; Spencer, Tiahna; Kovner, Rotem; Baqi, Younis; Müller, Christa E.; Correa, Merce; Salamone, John Elsevier (2016-01)Tremulous jaw movements (TJMs) have become a commonly used rat model of Parkinsonian tremor. TJMs can be induced by a number of neurochemical conditions that parallel those seen in human Parkinsonism, including DA depletion, ... -
Infusions of acetaldehyde into the arcuate nucleus of the hypothalamus induce motor activity in rats
Correa, Merce; Arizzi LaFrance, M.N.; Salamone, John Elsevier (2009)Aims: The hypothalamic arcuate nucleus (ARH) is one of the brain regions with the highest levels of catalase expression. Acetaldehyde, metabolized from ethanol in the CNS through the actions of catalase, has a role in the ... -
Insulin and Ventral Tegmental Dopamine: What's Impaired and What's Intact?
Salamone, John; Correa, Merce Elsevier (2013-04-02)Manipulations affecting mesolimbic dopamine transmission exert specific effects on normal and pathological aspects of motivation, altering some functions while sparing others. Labouèbe et al. (2013) show that insulin induced ... -
Intra-accumbens injections of the adenosine A(2A) agonist CGS 21680 affect effort-related choice behavior in rats
Stopper, Colin M.; Worden, Lila T.; Mingote, Susana; Port, Russell G.; Salamone, John; Font Hurtado, Laura; Pereira, Mariana; Farrar, Andrew M. Springer Verlag (2008)Rationale: Nucleus accumbens dopamine (DA) participates in the modulation of instrumental behavior, including aspects of behavioral activation and effort-related choice behavior. Rats with impaired accumbens DA transmission ... -
Lisdexamfetamine suppresses instrumental and consummatory behaviorssupported by foods with varying degrees of palatability: Exploration of abinge-like eating model
Presby, Rose; Rotolo, Renee; Yang, Jen-Hau; Correa, Merce; Salamone, John Elsevier (2020)Diets high in sugar or fat are associated with multiple health conditions, including binge eating disorder (BED). BED affects approximately 2% of the US adult population, and occurs more frequently in females. It is important ... -
Neurobiological basis of motivational deficits in psychopathology
Salamone, John; Koychev, Ivan; Correa, Merce; McGuire, Philip Elsevier (2015)In recent years, there has been increasing emphasis on the importance of motivational symptoms in depression, schizophrenia and other disorders. The present review discusses the conceptual background related to the construct ... -
Neurobiology and pharmacology of activational and effort-related aspects of motivation: rodent studies
Salamone, John; Correa, Merce Elsevier (2018-08)Behavioral activation and exertion of effort are fundamental aspects of motivation. Exertion of effort enables organisms to overcome obstacles that separate them from significant stimuli. Moreover, organisms must frequently ... -
Nucleus Accumbens Adenosine A2A Receptors Regulate Exertion of Effort by Acting on the Ventral Striatopallidal Pathway
Font Hurtado, Laura; Mingote, Susana; Farrar, Andrew M.; Vontell, Regina; Worden, Lila T.; Stopper, Colin M.; Port, Russell G.; Sink, Kelly S.; Bunce, Jamie G.; Chrobak, James; Salamone, John Society for Neuroscience (2008)Goal-directed actions are sensitive to work-related response costs, and dopamine in nucleus accumbens is thought to modulate the exertion of effort in motivated behavior. Dopamine-rich striatal areas such as nucleus ... -
Nucleus accumbens and effort-related functions: behavioral and neural markers of the interactions between adenosine A2A and dopamine D2 receptors
Farrar, Andrew M.; Segovia, Kristen N.; Randall, Patrick A.; Nunes, Eric J.; Collins, Lyndsey E.; Stopper, Colin M.; Port, Russell G.; Hockemeyer, J.; Müller, Christa E.; Correa, Merce; Salamone, John Elsevier (2010-04)Nucleus accumbens dopamine (DA) is a critical component of the brain circuitry regulating work output in reinforcement-seeking behavior and effort-related choice behavior. Moreover, there is evidence of an interaction ... -
Nucleus accumbens neurotransmission and effort-related choice behavior in food motivation: Effects of drugs acting on dopamine, adenosine, and muscarinic acetylcholine receptors
Nunes, Eric J.; Randall, Patrick A.; Podurgiel, Samantha J.; Correa, Merce; Salamone, John Elsevier (2013)Mesolimbic dopamine (DA) is a critical component of the brain circuitry regulating behavioral activation and effort-related processes. Although nucleus accumbens (NAc) DA depletions or antagonism leave aspects of appetite ... -
Oral Ingestion and Intraventricular Injection of Curcumin Attenuates the Effort-Related Effects of the VMAT-2 Inhibitor Tetrabenazine: Implications for Motivational Symptoms of Depression
Yohn, Samantha E.; Gorka, Dea; Mistry, Anisha; Collins, Samantha; Qian, Emily; Correa, Merce; Manchanda, Arushi; Bogner, Robin; Salamone, John American Chemical Society (2017-09)Effort-related choice tasks are used for studying depressive motivational symptoms such as anergia/fatigue. These studies investigated the ability of the dietary supplement curcumin to reverse the low-effort bias induced ... -
Partial reversal of the effort-related motivational effects of tetrabenazinewith the MAO-B inhibitor deprenyl (selegiline): Implications for treatingmotivational dysfunctions
Contreras Mora, Héctor; Rowland, Margaret; Yohn, Samantha E.; Correa, Merce; Salamone, John Elsevier (2018)People with depression and Parkinsonism frequently show effort-related motivational symptoms, such as an-ergia, psychomotor retardation, and fatigue. Tasks that assess effort-related choice are being used as animalmodels of ... -
Patterns of Neural Responses, Pavlovian-to-Instrumental Transfer, and Prediction of Relapse
Salamone, John; Correa, Merce (2019-12) -
Pharmacological studies of effort-related decision making using mouse touchscreen procedures: effects of dopamine antagonism do not resemble reinforcer devaluation by removal of food restriction
Yang, Jen-Hau; Presby, Rose; Jarvie, Adam A.; Rotolo, Renee; Fitch, R. Holly; Correa, Merce; Salamone, John Springer Verlag (2020)Rationale Effort-based decision-making tasks offer animals choices between preferred reinforcers that require high effort to obtain vs. low effort/low reward options. The neural mechanisms of effort-based choice are widely ... -
Piecing together the puzzle of acetaldehyde as a neuroactive agent
Correa, Merce; Salamone, John; Segovia, Kristen N.; Pardo Andrés, Marta; Longoni, Rosanna; Spina, Liliana; PEANA, Alessandra Tiziana; Vinci, Stefania; Acquas, Elio Elsevier (2012-01)Mainly known for its more famous parent compound, ethanol, acetaldehyde was first studied in the 1940s, but then research interest in this compound waned. However, in the last two decades, research on acetaldehyde has seen ... -
Potential anxiogenic effects of cannabinoid CB1 receptor antagonists/inverse agonists in rats: Comparisons between AM4113, AM251, and the benzodiazepine inverse agonist FG-7142
Sink, Kelly S.; Segovia, Kristen N.; Sink, J.; Randall, Patrick A.; Collins, Lyndsey E.; Correa, Merce; Markus, E. J.; Vemuri, Venkata Kiran; Makriyannis, Alexandros; Salamone, John Elsevier (2010)Cannabinoid CB1 inverse agonists suppress food-motivated behaviors, but may also induce psychiatric effects such as depression and anxiety. To evaluate behaviors potentially related to anxiety, the present experiments ... -
Preference for Exercise vs. More Sedentary Reinforcers: Validation of an Animal Model of Tetrabenazine-Induced Anergia
Carratalá-Ros, Carla; López Cruz, Laura; San Miguel Segura, Noemí; Ibáñez-Marín, Patricia; Martínez Verdú, Andrea; Salamone, John; Correa, Merce Frontiers Media (2020-01-30)Physical activities can have intrinsic motivational or reinforcing properties. The choice to engage in voluntary physical activity is undertaken in relation to the selection of other alternatives, such as sedentary ... -
Role of dopamine–adenosine interactions in the brain circuitry regulating effort-related decision making: insights into pathological aspects of motivation
Salamone, John; Correa, Merce; Farrar, Andrew M.; Nunes, Eric J.; Collins, Lyndsey E. Future Medicine (2010)Brain dopamine, particularly in the nucleus accumbens, has been implicated in activational aspects of motivation and effort-related processes. Accumbens dopamine depletions reduce the tendency of rats to work for food, and ...