Listar PSB_Articles por autoría "9d66cb3e-ca30-4b77-90d1-3fa30e9543d5"
Mostrando ítems 1-15 de 15
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Adenosine A2A receptor antagonism and genetic deletion attenuate the effects of dopamine D2 antagonism on effort-based decision making in mice
Pardo Andrés, Marta; López Cruz, Laura; Valverde, Olga; LEDENT, Catherine; Baqi, Younis; Müller, Christa E.; Salamone, John; Correa, Merce Elsevier (2012)Brain dopamine (DA) and adenosine interact in the regulation of behavioral activation and effort-related processes. In the present studies, a T-maze task was developed in mice for the assessment of effort-related decision ... -
Caffeine modulates voluntary alcohol intake in mice depending on theaccess conditions: Involvement of adenosine receptors and the role of individual differences
San Miguel Segura, Noemí; López Cruz, Laura; Müller, Christa E.; Salomone, John D.; Correa, Merce Elsevier (2019)Caffeine is the most consumed psychoactive stimulant and the main active ingredient of energy drinks.Epidemiology studies have shown a positive correlation between the consumption of energy drinks and that ofethanol. The ... -
Conditional neural knockout of the adenosine A2A receptor and pharmacological A2A antagonism reduce pilocarpine-induced tremulous jaw movements: Studies with a mouse model of parkinsonian tremor
Salamone, John; Collins-Praino, Lyndsey E.; Pardo Andrés, Marta; Podurgiel, Samantha J.; Baqi, Younis; Müller, Christa E.; Schwarzschild, Michael A.; Correa, Merce Elsevier (2013)Tremulous jaw movements are rapid vertical deflections of the lower jaw that resemble chewing but are not directed at any particular stimulus. In rats, tremulous jaw movements can be induced by a number of conditions that ... -
Dopamine/adenosine interactions related to locomotion and tremor in animal models: Possible relevance to parkinsonism
Salamone, John; Ishiwari, K.; Betz, Adrienne J.; Farrar, Andrew M.; Mingote, Susana; Font Hurtado, Laura; Hockemeyer, J.; Müller, Christa E.; Correa, Merce Elsevier (2008)Adenosine A<sub>2A</sub> antagonists can exert antiparkinsonian effects in animal models. Recent experiments studied the ability of MSX-3 (an adenosine A<sub>2A</sub> antagonist) to reverse the locomotor suppression and ... -
Dopaminergic modulation of effort-related choice behavior as assessed by a progressive ratio chow feeding choice task: pharmacological studies and the role of individual differences
Randall, Patrick A.; Pardo Andrés, Marta; Nunes, Eric J.; López Cruz, Laura; Vemuri, Venkata Kiran; Makriyannis, Alexandros; Baqi, Younis; Müller, Christa E.; Correa, Merce; Salamone, John Public Library of Science (2012)Mesolimbic dopamine (DA) is involved in behavioral activation and effort-related processes. Rats with impaired DA transmission reallocate their instrumental behavior away from food-reinforced tasks with high response ... -
Effect of subtype-selective adenosine receptor antagonists on basal or haloperidol-regulated striatal function: Studies of exploratory locomotion and c-Fos immunoreactivity in outbred and A2AR KO mice
Pardo Andrés, Marta; López Cruz, Laura; Valverde, Olga; LEDENT, Catherine; Baqi, Younis; Müller, Christa E.; Salamone, John; Correa, Merce Elsevier (2013-06-15)Behavioral activation is regulated by dopamine (DA) in striatal areas. At low doses, while typical antipsychotic drugs produce psychomotor slowing, psychostimulants promote exploration. Minor stimulants such as caffeine, ... -
Effort-related motivational effects of the pro-inflammatory cytokine interleukin 1-beta: studies with the concurrent fixed ratio 5/ chow feeding choice task
Correa, Merce; Nunes, Eric J.; Randall, Patrick A.; Salamone, John; Estrada, Alexavier; Epling, Brian; Hart, Evan E.; Lee, Christie A.; Müller, Christa E.; Baqi, Younis Springer (2014-02)Rationale. Effort-related motivational symptoms such as anergia and fatigue are common in patients with depression and other disorders. Research implicates pro-inflammatory cytokines in depression, and administration of ... -
Effort-related motivational effects of the pro-inflammatory cytokine interleukin-6: pharmacological and neurochemical characterization
Yohn, Samantha E.; Arif, Yumna; Haley, Allison; Tripodi, Guiseppe; Baqi, Younis; Müller, Christa E.; San Miguel Segura, Noemí; Correa, Merce; Salamone, John Springer Verlag (2016)Rationale Motivational dysfunctions such as anergia, fatigue, and reduced effort expenditure are common in patients with depression and other disorders. Pro-inflammatory cytokines are implicated in depression, and ... -
Ethanol and Caffeine Effects on Social Interaction and Recognition in Mice: Involvement of Adenosine A(2A) and A(1) Receptors
López Cruz, Laura; San Miguel Segura, Noemí; Bayarri Iturralde, Pilar; Baqi, Younis; Müller, Christa E.; Salomone, John D.; Correa, Merce Frontiers Media (2016-11)Ethanol and caffeine are frequently consumed in combination and have opposite effects on the adenosine system: ethanol metabolism leads to an increase in adenosine levels, while caffeine is a non-selective adenosine ... -
Induction of oral tremor in mice by the acetylcholinesterase inhibitor galantamine: Reversal with adenosine A2A antagonism
Podurgiel, Samantha J.; Spencer, Tiahna; Kovner, Rotem; Baqi, Younis; Müller, Christa E.; Correa, Merce; Salamone, John Elsevier (2016-01)Tremulous jaw movements (TJMs) have become a commonly used rat model of Parkinsonian tremor. TJMs can be induced by a number of neurochemical conditions that parallel those seen in human Parkinsonism, including DA depletion, ... -
Nucleus accumbens and effort-related functions: behavioral and neural markers of the interactions between adenosine A2A and dopamine D2 receptors
Farrar, Andrew M.; Segovia, Kristen N.; Randall, Patrick A.; Nunes, Eric J.; Collins, Lyndsey E.; Stopper, Colin M.; Port, Russell G.; Hockemeyer, J.; Müller, Christa E.; Correa, Merce; Salamone, John Elsevier (2010-04)Nucleus accumbens dopamine (DA) is a critical component of the brain circuitry regulating work output in reinforcement-seeking behavior and effort-related choice behavior. Moreover, there is evidence of an interaction ... -
The novel adenosine A2A antagonist prodrug MSX-4 is effective in animal models related to motivational and motor functions
Santerre, Jessica L.; Nunes, Eric J.; Kovner, Rotem; Leser, Chelsea E.; Randall, Patrick A.; Collins, Lyndsey E.; López Cruz, Laura; Correa, Merce; Baqi, Younis; Müller, Christa E.; Salamone, John Elsevier (2012)Adenosine A2A and dopamine D2 receptors interact to regulate diverse aspects of ventral and dorsal striatal functions related to motivational and motor processes, and it has been suggested that adenosine A2A antagonists ... -
The vesicular monoamine transporter (VMAT-2) inhibitor tetrabenazine induces tremulous jaw movements in rodents: Implications for pharmacological models of parkinsonian tremor
López Cruz, Laura; Podurgiel, Samantha J.; Nunes, Eric J.; Yohn, Samantha E.; Barber, J.; Thompson, A.; Milligan, M.; Lee, Christie A.; Pardo Andrés, Marta; Valverde, Olga; LEDENT, Catherine; Baqi, Younis; Müller, Christa E.; Correa, Merce; Salamone, John Elsevier (2013)Tetrabenazine (TBZ) is a reversible inhibitor of vesicular monoamine storage that is used to treat Huntington’s disease. TBZ preferentially depletes striatal dopamine (DA), and patients being treated with TBZ often experience ... -
The VMAT-2 Inhibitor Tetrabenazine Affects EffortRelated Decision Making in a Progressive Ratio/Chow Feeding Choice Task: Reversal with Antidepressant Drugs
Randall, Patrick A.; Lee, Christie A.; Nunes, Eric J.; Yohn, Samantha E.; Nowak, Victoria; Khan, Bilal; Shah, Priya; Pandit, Saagar; Vemuri, Venkata Kiran; Makriyannis, Alexandros; Baqi, Younis; Müller, Christa E.; Correa, Merce; Salamone, John Public Library of Science (2014)Behavioral activation is a fundamental feature of motivation, and organisms frequently make effort-related decisions based upon evaluations of reinforcement value and response costs. Furthermore, people with major depression ... -
The VMAT-2 inhibitor tetrabenazine alters effort-related decision making as measured by the T-maze barrier choice task: reversal with the adenosine A2A antagonist MSX-3 and the catecholamine uptake blocker bupropion
Yohn, Samantha E.; Thompson, Christian; Randall, Patrick A.; Lee, Christie A.; Müller, Christa E.; Baqi, Younis; Correa, Merce; Salamone, John Springer Verlag (2015)Rationale Depressed people show effort-related motivational symptoms, such as anergia, retardation, lassitude, and fatigue. Animal tests can model these motivational symptoms, and the present studies characterized the ...