Listar PSB_Articles por autoría "8808a898-bed6-4a85-a74c-61b879119b64"
Mostrando ítems 1-3 de 3
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Effort-related decision making in humanized COMT mice: Effects ofVal158Met polymorphisms and possible implications for negative symptomsin humans
Yang, Jen-Hau; Presby, Rose; Cayer, Suzanne; Rotolo, Renee; Perrino, Peter A.; Fitch, R. Holly; Correa, Merce; Chesler, Elissa J.; Salamone, John Elsevier (2020)Catechol-o-methyltransferase (COMT) is an enzyme that metabolizes catecholamines, and is crucial for clearanceof dopamine (DA) in prefrontal cortex. Val158Met polymorphism, which causes a valine (Val) to methionine(Met) ... -
Pharmacological studies of effort-related decision making using mouse touchscreen procedures: effects of dopamine antagonism do not resemble reinforcer devaluation by removal of food restriction
Yang, Jen-Hau; Presby, Rose; Jarvie, Adam A.; Rotolo, Renee; Fitch, R. Holly; Correa, Merce; Salamone, John Springer Verlag (2020)Rationale Effort-based decision-making tasks offer animals choices between preferred reinforcers that require high effort to obtain vs. low effort/low reward options. The neural mechanisms of effort-based choice are widely ... -
The dopamine depleting agent tetrabenazine alters effort-related decision making as assessed by mouse touchscreen procedures
Yang, Jen-Hau; Presby, Rose; Rotolo, Renee; Quiles, Taina; Okifo, Kevin; Zorda, Emma; Fitch, R. Holly; Correa, Merce; Salamone, John Springer (2020)Rationale Effort-based decision-making tasks allow animals to choose between preferred reinforcers that require high effort to obtain vs. low-effort/low reward options. Mesolimbic dopamine (DA) and related neural systems ...