• openAccess   Bioactive potential of silica coatings and its effect on the adhesion of proteins to titanium implants 

      Romero-Gavilán, Francisco J; Gomes, Nuno; Sánchez-Pérez, Ana María; García-Arnáez, Iñaki; Elortza, Felix; Azkargorta, Mikel; Martín de Llano, J.J.; Carda, C.; Gurruchaga, Marilo; Suay, Julio; Goñi, Isabel Elsevier (2018-02-01)
      There is an ever-increasing need to develop dental implants with ideal characteristics to achieve specific and desired biological response in the scope of improve the healing process post-implantation. Following that ...
    • openAccess   Complement proteins regulating macrophage polarisation on biomaterials 

      Gomes, Nuno; Romero-Gavilán, Francisco J; Zhang, Yiyue; Martinez Ramos, Cristina; Elortza, Felix; Azkargorta, Mikel; Martín de Llano, J. J.; GURRUCHAGA, MARILO; Goñi, Isabel; van den Beucken, J.J.J.P.; Suay, Julio Elsevier (2019-09-01)
      One of the events occurring when a biomaterial is implanted in an host is the protein deposition onto its surface, which might regulate cell responses. When a biomaterial displays a compromised biocompatibility, distinct ...
    • openAccess   Development and characterisation of strontium-doped sol-gel coatings to optimise the initial bone regeneration processes 

      García-Arnáez, Iñaki; Cerqueira, Andreia; Romero-Gavilán, Francisco J; Elortza, Felix; Azkargorta, Mikel; Iloro, Ibon; Suay, Julio; Goñi, Isabel; GURRUCHAGA, MARILO Elsevier (2022)
      Strontium plays an important role in bone regeneration; it promotes the differentiation and maturation of osteoblasts and inhibits the activity of osteoclasts. Our principal objective in this study was to formulate new ...
    • closedAccess   Estudio in vitro e in vivo de un recubrimiento osteoinductor para implantes dentales 

      Goñi, Isabel; GURRUCHAGA, MARILO; Juan Díaz, M.; Suay, Julio; Da Silva, Sara; Lara, Irene; Franco, Jaime; Coso, Antonio Grupo Editorial Peldaño (2014)
    • openAccess   Insight into the antibacterial mechanism of Cu-enriched sol–gel coatings employing proteomics 

      Romero-Gavilán, Francisco J; García-Arnáez, Iñaki; Cerqueira, Andreia; Scalschi, Loredana; Vicedo, Begonya; Villagrasa, Alejandro; Izquierdo, Raúl; Elortza, Felix; Gurruchaga, Mariló; Goñi, Isabel; Suay, Julio Royal Society of Chemistry (2023)
      Advanced antibacterial biomaterials can help reduce the severe consequences of infections. Using copper compounds is an excellent option to achieve this goal; they offer a combination of regenerative and antimicrobial ...
    • openAccess   Protein adsorption/desorption dynamics on Ca‑enriched titanium surfaces: biological implications 

      Romero-Gavilán, Francisco J; Cerqueira, Andreia; Anitua, Eduardo; Tejero, Ricardo; García-Arnáez, Iñaki; Martinez Ramos, Cristina; Ozturan, Seda; Izquierdo Escrig, Raul; Azkargorta, Mikel; Elortza, Felix; GURRUCHAGA, MARILO; Goñi, Isabel; Suay, Julio Springer (2021-08-27)
      Calcium ions are used in the development of biomaterials for the promotion of coagulation, bone regeneration, and implant osseointegration. Upon implantation, the time-dependent release of calcium ions from titanium implant ...
    • openAccess   Proteomic analysis of silica hybrid sol-gel coatings: a potential tool for predicting the biocompatibility of implants in vivo 

      Romero-Gavilán, Francisco J; Sánchez-Pérez, Ana María; Gomes, Nuno; Azkargorta, Mikel; Iloro, Ibon; Elortza, Felix; Gurruchaga, Marilo; Goñi, Isabel; Suay, Julio Taylor & Francis (2017)
      The interactions of implanted biomaterials with the host organism determine the success or failure of an implantation. Normally, their biocompatibility is assessed using in vitro tests. Unfortunately, in vitro and in vivo ...
    • openAccess   Proteomic evaluation of human osteoblast responses to titanium implants over time 

      Romero-Gavilán, Francisco J; Cerqueira, Andreia; García-Arnáez, Iñaki; Azkargorta, Mikel; Elortza, Felix; GURRUCHAGA, MARILO; Goñi, Isabel; Suay, Julio Wiley (2022-08-30)
      Titanium is widely used in bone prostheses due to its excellent biocompatibility and osseointegration capacity. To understand the effect of sandblasted acid-etched (SAE) Ti implants on the biological responses of human ...
    • openAccess   Silica-gelatin hybrid sol-gel coatings: A proteomic study with biocompatibility implications 

      Gomes, Nuno; Romero-Gavilán, Francisco J; Lara, Irene; Elortza, Felix; Azkargorta, Mikel; Lloro, Ibon; Ibáñez, Maria; Martín de Llano, J. J.; GURRUCHAGA, MARILO; Goñi, Isabel; Suay, Julio; Sánchez-Pérez, Ana María Wiley (2018-05)
      Osseointegration, including the foreign body reaction to biomaterials, is an immune‐modulated, multifactorial, and complex healing process in which various cells and mediators are involved. The buildup of the osseointegration ...
    • openAccess   The effect of strontium incorporation into sol-gel biomaterials on their protein adsorption and cell interactions 

      Romero-Gavilán, Francisco J; Gomes, Nuno; García-Arnáez, Iñaki; Martinez Ramos, Cristina; Elortza, Felix; Azkargorta, Mikel; Iloro, Ibon; GURRUCHAGA, MARILO; Suay, Julio; Goñi, Isabel Elsevier (2019-02-01)
      It is known strontium can both inhibit the osteoclast formation and stimulate the osteoblast maturation, so biomaterials containing this element can favour bone structure stabilisation. The addition of Sr to biomaterials ...
    • openAccess   Using osteogenic medium in the in vitro evaluation of bone biomaterials: Artefacts due to a synergistic effect 

      Romero-Gavilán, Francisco J; García-Arnáez, Iñaki; Cerqueira, Andreia; Arias-Mainer, Carlos; Azkargorta, Mikel; Elortza, Felix; Izquierdo, Raúl; Gurruchaga, Mariló; Goñi, Isabel Elsevier (2023)
      In vitro tests using bone cells to evaluate the osteogenic potential of biomaterials usually employ the osteogenic medium (OM). The lack of correlation frequently reported between in vitro and in vivo studies in bone ...