Visualitza Departament: Psicologia Bàsica, Clínica i Psicobiologia per paraule clau "Acetaldehyde"
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Acetate as an active metabolite of ethanol: studies of locomotion, loss of righting reflex, and anxiety in rodents
Frontiers (2013)It has been postulated that a number of the central effects of ethanol are mediated via ethanol metabolites: acetaldehyde and acetate. Ethanol is known to produce a large variety of behavioral actions such anxiolysis, ... -
Acquisition and reconditioning of ethanol-induced conditioned place preference in mice is blocked by the H2O2 scavenger alpha lipoic acid
Springer (2012)Rationale Hydrogen peroxide (H2 O2) is the co-substrate used by catalase to metabolize ethanol to acetaldehyde in the brain. This centrally formed acetaldehyde has been involved in several ethanol-related behaviors. ... -
Alpha-lipoic acid, a scavenging agent for H2O2, reduces ethanol-stimulated locomotion in mice
Springer-Verlag (2011-07-19)Rationale The main system of central ethanol oxidation is mediated by the enzyme catalase. By reacting with H2O2, brain catalase forms compound I (the catalase–H2O2 system), which is able to oxidize ethanol to acetaldehyde ... -
Anxiogenic and stress-inducingeffects of peripherally administeredacetaldehyde in mice: Similarities with the disulfiram–ethanol reaction
Elsevier (2012)Peripheral accumulation of acetaldehyde, the first metabolite of ethanol, produces autonomic responses in humans called “flushing”. The aversive characteristics of flushing observed in some populations with an isoform of ... -
Infusions of acetaldehyde into the arcuate nucleus of the hypothalamus induce motor activity in rats
Elsevier (2009)Aims: The hypothalamic arcuate nucleus (ARH) is one of the brain regions with the highest levels of catalase expression. Acetaldehyde, metabolized from ethanol in the CNS through the actions of catalase, has a role in the ... -
Involvement of brain catalase activity in the acquisition of ethanol-induced conditioned place preference
Elsevier (2008)It has been suggested that some of the behavioral effects produced by ethanol are mediated by its first metabolite, acetaldehyde. The present research addressed the hypothesis that catalase-dependent metabolism of ethanol ... -
Modulation of ethanol-induced conditioned place preference in mice by 3-amino-1,2,4-triazole and D-penicillamine depends on ethanol dose and number of conditioning trials
Springer (2013)Previous studies have shown that both 3-amino-1,2,4-triazole (AT), which inhibits metabolism of ethanol (EtOH) to acetaldehyde by inhibiting catalase, and D-penicillamine (D-P), an acetaldehyde-sequestering agent, modulate ... -
Piecing together the puzzle of acetaldehyde as a neuroactive agent
Elsevier (2012-01)Mainly known for its more famous parent compound, ethanol, acetaldehyde was first studied in the 1940s, but then research interest in this compound waned. However, in the last two decades, research on acetaldehyde has seen ... -
Reduction in Central H2O2 Levels Prevents Voluntary Ethanol Intake in Mice: A Role for the Brain Catalase- H2O2 System in Alcohol Binge Drinking
Wiley (2014-01)Background: Hydrogen peroxide (H2O2) is the cosubstrate used by the enzyme catalase to form Compound I (the catalase-H2O2 system), which is the major pathway for the conversion of ethanol (EtOH) into acetaldehyde in the ... -
The H2O2 scavenger ebselen decreases ethanol-induced locomotor stimulation in mice
Elsevier (2012)Background In the brain, the enzyme catalase by reacting with H2O2 forms Compound I (catalase–H2O2 system), which is the main system of central ethanol metabolism to acetaldehyde. Previous research has demonstrated that ... -
The MAO-A inhibitor clorgyline reduces ethanol-induced locomotion and its volitional intake in mice
Elsevier (2014)Hydrogen peroxide is the co-substrate used by the enzyme catalase to form Compound I (the catalase–H2O2 system), which is the major pathway for the conversion of ethanol (EtOH) into acetaldehyde in the brain. This acetaldehyde ...