Listar Departament: Psicologia Bàsica, Clínica i Psicobiologia por autoría "9fce0b0f-383f-4840-9777-872cbfe38761"
Mostrando ítems 21-40 de 80
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Dopamine and Food Addiction: Lexicon Badly Needed
Salamone, John; Correa, Merce Elsevier (2013-05-01)Over the last few years, the concept of food addiction has become a common feature in the scientific literature, as well as the popular press. Nevertheless, the use of the term addiction to describe pathological aspects ... -
Dopamine depletion shifts behavior from activity based reinforcers tomore sedentary ones and adenosine receptor antagonism reversesthat shift: Relation to ventral striatum DARPP32 phosphorylationpatterns
López Cruz, Laura; SanMiguel, Noemí; Carratalá-Ros, Carla; Monferrer Sales, Lidón; Salamone, John; Correa, Merce Elsevier (2018)The mesolimbic dopamine (DA) system plays a critical role in behavioral activation and effort-baseddecision-making. DA depletion produces anergia (shifts to low effort options) in animals tested oneffort-based decision-making ... -
Dopamine, behavioral economics, and effort
Salamone, John; Correa, Merce; Farrar, Andrew M.; Nunes, Eric J.; Pardo Andrés, Marta Frontiers Research Foundation (2009)There are numerous problems with the hypothesis that brain dopamine (DA) systems, particularly in the nucleus accumbens, directly mediate the rewarding or primary motivational characteristics of natural stimuli such as ... -
Dopamine, Effort-Based Choice, and Behavioral Economics: Basic and Translational Research
Salamone, John; Correa, Merce; Yang, Jen-Hau; Rotolo, Renee; Presby, Rose Frontiers Media (2018-03)Operant behavior is not only regulated by factors related to the quality or quantity of reinforcement, but also by the work requirements inherent in performing instrumental actions. Moreover, organisms often make ... -
Dopamine/adenosine interaction in effort-related processes in rodents: Studies using T-Maze paradigm in mice
Pardo, Marta; Ordaz, G.; Salamone, John; Correa, Merce Universitat Jaume I (2008)Humans and animals realize cost/benefits analysis of our responses with the goal of use the lowest energy possible to obtain the major benefit. Mesolimbic dopamine (DA) is a critic component in the cerebral circuitry ... -
Dopamine/adenosine interactions involved in effort-related aspects of food motivation
Salamone, John; Correa, Merce Elsevier (2009)Nucleus accumbens dopamine (DA) is involved in effort-related aspects of food motivation. Accumbens DA depletions reduce the tendency of rats to work for food, and alter effort-related choice, but leave other aspects of ... -
Dopamine/adenosine interactions related to locomotion and tremor in animal models: Possible relevance to parkinsonism
Salamone, John; Ishiwari, K.; Betz, Adrienne J.; Farrar, Andrew M.; Mingote, Susana; Font Hurtado, Laura; Hockemeyer, J.; Müller, Christa E.; Correa, Merce Elsevier (2008)Adenosine A<sub>2A</sub> antagonists can exert antiparkinsonian effects in animal models. Recent experiments studied the ability of MSX-3 (an adenosine A<sub>2A</sub> antagonist) to reverse the locomotor suppression and ... -
Dopaminergic modulation of effort-related choice behavior as assessed by a progressive ratio chow feeding choice task: pharmacological studies and the role of individual differences
Randall, Patrick A.; Pardo Andrés, Marta; Nunes, Eric J.; López Cruz, Laura; Vemuri, Venkata Kiran; Makriyannis, Alexandros; Baqi, Younis; Müller, Christa E.; Correa, Merce; Salamone, John Public Library of Science (2012)Mesolimbic dopamine (DA) is involved in behavioral activation and effort-related processes. Rats with impaired DA transmission reallocate their instrumental behavior away from food-reinforced tasks with high response ... -
Effect of subtype-selective adenosine receptor antagonists on basal or haloperidol-regulated striatal function: Studies of exploratory locomotion and c-Fos immunoreactivity in outbred and A2AR KO mice
Pardo Andrés, Marta; López Cruz, Laura; Valverde, Olga; LEDENT, Catherine; Baqi, Younis; Müller, Christa E.; Salamone, John; Correa, Merce Elsevier (2013-06-15)Behavioral activation is regulated by dopamine (DA) in striatal areas. At low doses, while typical antipsychotic drugs produce psychomotor slowing, psychostimulants promote exploration. Minor stimulants such as caffeine, ... -
Effects of caffeine on ethanol-elicited place preference, place aversion and ERK phosphorylation in CD-1 mice
Porru, Simona; Maccioni, Riccardo; Bassareo, Valentina; PEANA, Alessandra Tiziana; Salamone, John SAGE Publishing (2020-10-24)Background: Epidemiological studies indicate a rise in the combined consumption of caffeinated and alcoholic beverages, which can lead to increased risk of alcoholic-beverage overconsumption. However, the effects of the ... -
Effects of lisdexamfetamine and s-citalopram, alone and in combination, on effort-related choice behavior in the rat
Yohn, Samantha E.; López Cruz, Laura; Hutson, Peter H.; Correa, Merce; Salamone, John Springer Verlag (2016)Rationale Effort-related motivational symptoms, such as anergia, psychomotor retardation, and fatigue, are an important aspect of depression and other disorders. Motivational symptoms are resistant to some treatments, ... -
Effects of the adenosine A2A antagonist KW 6002 (istradefylline) on pimozide-induced oral tremor and striatal c-Fos expression: comparisons with the muscarinic antagonist tropicamide
Betz, Adrienne J.; Vontell, Regina; Valenta, J.; Worden, Lila T.; Sink, Kelly S.; Font Hurtado, Laura; Correa, Merce; Sager, Thomas Nikolaj; Salamone, John Elsevier (2009-09)Typical antipsychotic drugs, including haloperidol and pimozide, have been shown to produce parkinsonian motor effects such as akinesia and tremor. Furthermore, there is an antagonistic interaction between adenosine A2A ... -
Effects of the dopamine depleting agent tetrabenazine in tests evaluating different components of depressive-like behavior in mice : sex-dependent response to antidepressant drugs with SERT and DAT blocker profiles
Carratalá Ros, Carla; Martínez‑Verdú, Andrea; Olivares-García, Régulo; Salamone, John; Correa, Merce Springer Nature (2023-07-05)Background ; Depression is a disorder twice as common in women than in men. There are sex differences in the symptomatology and treatment response to this disorder. Impairments in behavioral activation (i.e. anergia, ... -
Effects of the dopamine depleting agent tetrabenazine on detailed temporal parameters of effort-related choice responding
Ren, Naxin; Carratalá-Ros, Carla; Ecevitoglu, Alev; Rotolo, Renee; Edelstein, Gayle A; Presby, Rose; Stevenson, Ian; Chrobak, James; Salamone, John Society for the Experimental Analysis of Behavior (2022-03-28)The dopamine-depleting agent tetrabenazine alters effort-based choice, suppressing food-reinforced behaviors with high response requirements, while increasing selection of low-cost options. In the present experiments, rats ... -
Effort-related decision making in humanized COMT mice: Effects ofVal158Met polymorphisms and possible implications for negative symptomsin humans
Yang, Jen-Hau; Presby, Rose; Cayer, Suzanne; Rotolo, Renee; Perrino, Peter A.; Fitch, R. Holly; Correa, Merce; Chesler, Elissa J.; Salamone, John Elsevier (2020)Catechol-o-methyltransferase (COMT) is an enzyme that metabolizes catecholamines, and is crucial for clearanceof dopamine (DA) in prefrontal cortex. Val158Met polymorphism, which causes a valine (Val) to methionine(Met) ... -
Effort-related motivational effects of the pro-inflammatory cytokine interleukin 1-beta: studies with the concurrent fixed ratio 5/ chow feeding choice task
Correa, Merce; Nunes, Eric J.; Randall, Patrick A.; Salamone, John; Estrada, Alexavier; Epling, Brian; Hart, Evan E.; Lee, Christie A.; Müller, Christa E.; Baqi, Younis Springer (2014-02)Rationale. Effort-related motivational symptoms such as anergia and fatigue are common in patients with depression and other disorders. Research implicates pro-inflammatory cytokines in depression, and administration of ... -
Effort-related motivational effects of the pro-inflammatory cytokine interleukin-6: pharmacological and neurochemical characterization
Yohn, Samantha E.; Arif, Yumna; Haley, Allison; Tripodi, Guiseppe; Baqi, Younis; Müller, Christa E.; San Miguel Segura, Noemí; Correa, Merce; Salamone, John Springer Verlag (2016)Rationale Motivational dysfunctions such as anergia, fatigue, and reduced effort expenditure are common in patients with depression and other disorders. Pro-inflammatory cytokines are implicated in depression, and ... -
Energizing effects of bupropion on effortful behaviors in mice under positive and negative test conditions: modulation of DARPP-32 phosphorylation patterns
Carratalá-Ros, Carla; Olivares-García, Régulo; Martínez-Verdú, Andrea; Arias-Sandoval, Edgar; Salamone, John; Correa, Merce Springer (2021-09-09)Motivational symptoms such as anergia, fatigue, and reduced exertion of effort are seen in depressed people. To model this, nucleus accumbens (Nacb) dopamine (DA) depletions are used to induce a low-effort bias in rodents ... -
Evaluation of the effort-related motivational effects of the novel dopamine uptake inhibitor PRX-14040
Yohn, Samantha E.; Gogoj, Augustyna; Haque, Aileen; López Cruz, Laura; Haley, Allison; Huxley, Philip; Baskin, Patricia; Correa, Merce; Salamone, John Elsevier (2016)Psychiatric disorders are often marked by effort-related motivational symptoms such as anergia, fatigue, psychomotor retardation, and alterations in effort-based decision making. Animal studies of effort-related choice ... -
Forebrain circuitry involved in effort-related choice: Injections of the GABAA agonist muscimol into ventral pallidum alter response allocation in food-seeking behavior
Farrar, Andrew M.; Font Hurtado, Laura; Pereira, Mariana; Mingote, Susana; Bunce, Jamie G.; Chrobak, James; Salamone, John Elsevier (2008-03)Organisms often make effort-related choices based upon assessments of motivational value and work requirements. Nucleus accumbens dopamine is a critical component of the brain circuitry regulating work output in ...