Nigral degeneration correlates with persistent activation of cerebellar Purkinje cells in MPTP-treated monkeys
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Other documents of the author: Heman, Paola; Barcia, Carlos; Gómez, Aurora; Ros Gómez, Carmen María; Ros Bernal, Francisco; Yuste Jiménez, José Enrique; De Pablos, Vicente; Fernández Villalba, Emiliano; Toledo-Cárdenas, María Rebeca; Herrero Ezquerro, María Trinidad
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Show full item recordcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/36080
comunitat-uji-handle3:10234/36082
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Title
Nigral degeneration correlates with persistent activation of cerebellar Purkinje cells in MPTP-treated monkeysAuthor (s)
Date
2012Publisher
Universidad de MurciaISSN
0213-3911; 1699-5848Bibliographic citation
Histol Histopathol (2012) 27: 89-94Type
info:eu-repo/semantics/articlePublisher version
http://www.hh.um.es/2012/HH_27_1_2012.htmVersion
info:eu-repo/semantics/publishedVersionSubject
Abstract
In the present work we analyze the
cerebellum of chronic parkinsonian monkeys in order to
clarify whether chronic mesencephalic depletion is
associated with long term activation of the cerebellar
neurons in chronic ... [+]
In the present work we analyze the
cerebellum of chronic parkinsonian monkeys in order to
clarify whether chronic mesencephalic depletion is
associated with long term activation of the cerebellar
neurons in chronic Parkinsonism. In our study, we
observed a persistent activation of Purkinje cells in the
cerebellum of chronic parkinsonian macaques,
characterized by the expression of c-Fos, which
correlated with dopaminergic degeneration. These
results are compatible with the results observed in fMRI
in Parkinson’s disease patients, and may contribute to
the understanding of additional alterations in the brain
circuitry in Parkinsonism. [-]
Is part of
Histology and Histopathology, 2012, Num. 27Rights
http://rightsstatements.org/vocab/CNE/1.0/
info:eu-repo/semantics/openAccess
info:eu-repo/semantics/openAccess
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- MED_Articles [667]