Nigral degeneration correlates with persistent activation of cerebellar Purkinje cells in MPTP-treated monkeys
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Altres documents de l'autoria: Heman, Paola; Barcia, Carlos; Gómez, Aurora; Ros Gómez, Carmen María; Ros Bernal, Francisco; Yuste Jiménez, José Enrique; De Pablos, Vicente; Fernández Villalba, Emiliano; Toledo-Cárdenas, María Rebeca; Herrero Ezquerro, María Trinidad
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Mostra el registre complet de l'elementcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/36080
comunitat-uji-handle3:10234/36082
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INVESTIGACIONMetadades
Títol
Nigral degeneration correlates with persistent activation of cerebellar Purkinje cells in MPTP-treated monkeysAutoria
Data de publicació
2012Editor
Universidad de MurciaISSN
0213-3911; 1699-5848Cita bibliogràfica
Histol Histopathol (2012) 27: 89-94Tipus de document
info:eu-repo/semantics/articleVersió de l'editorial
http://www.hh.um.es/2012/HH_27_1_2012.htmVersió
info:eu-repo/semantics/publishedVersionParaules clau / Matèries
Resum
In the present work we analyze the
cerebellum of chronic parkinsonian monkeys in order to
clarify whether chronic mesencephalic depletion is
associated with long term activation of the cerebellar
neurons in chronic ... [+]
In the present work we analyze the
cerebellum of chronic parkinsonian monkeys in order to
clarify whether chronic mesencephalic depletion is
associated with long term activation of the cerebellar
neurons in chronic Parkinsonism. In our study, we
observed a persistent activation of Purkinje cells in the
cerebellum of chronic parkinsonian macaques,
characterized by the expression of c-Fos, which
correlated with dopaminergic degeneration. These
results are compatible with the results observed in fMRI
in Parkinson’s disease patients, and may contribute to
the understanding of additional alterations in the brain
circuitry in Parkinsonism. [-]
Publicat a
Histology and Histopathology, 2012, Num. 27Drets d'accés
http://rightsstatements.org/vocab/CNE/1.0/
info:eu-repo/semantics/openAccess
info:eu-repo/semantics/openAccess
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- MED_Articles [667]