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Synthesis and Biological Evaluation of Small Molecules as Potential Anticancer Multitarget Agents
(MDPI, 2022-06-24)
Twenty-six triazole-based derivatives were designed for targeting both PD-L1 (programmed death receptor ligand 1) and VEGFR-2 (vascular endothelial growth factor receptor 2). These compounds were synthetized and biologically ...
Styryl carbamate backbones for the discovery of TME-disrupting agents
(Elsevier, 2024)
Twenty-one styryl carbamates have been designed, synthetized and characterized by their physical properties. Afterwards, their potential activity as tumor microenvironment disruptors has been evaluated. First, antiproliferative ...
Understanding the rapid reoxidation process and the electrical properties of Spark Plasma sintered pyrochlores
(2024-02-07)
Pyrochlore structures with composition Pr2−xSmxZr2O7 (x = 0, 1, and 2) were synthetized and studied. Spark Plasma Sintering (SPS) was employed to produce ceramics with over 95% of relative density. The reoxidation behavior ...
Sustainable inorganic pigments with high near-infra-red reflectance based on Fe3+ doped YAlO3 for high temperature applications
(Elsevier, 2023-10-15)
Non-toxic inorganic pigments based on the Fe(III)-doped YAlO3 with high near-infra-red (NIR) reflectance were synthesized by a modified Pechini method at 1200 °C. A complete solid solution in the YAl1−xFexO3 system (0 ≤x ...
Tools and new metric (Macrocyclization Environmental Impact - MEI) to tackle the sustainability of macrocyclization reactions
(Elsevier, 2023-10-06)
Albeit the numerous scientific advantages provided by macrocyclic compounds, there is still a significant gap between the “proof of concept” research and their application. This is a direct consequence of the challenging ...
Chiral Catalysts for the Enantioselective Carbon Dioxide-Based Cyclic Carbonates and Polycarbonates
(MDPI, 2023-11-14)
Using carbon dioxide as a feedstock for synthesizing organic molecules with added value can contribute to a more sustainable chemical industry since CO2 is an abundant, inexpensive, and nontoxic renewable carbon resource. ...
Tetrazole derivatives as potent immunomodulatory agents in tumor microenvironment
(Elsevier, 2023-11-01)
Twenty-seven compounds bearing a tetrazole ring as a central unit have been designed, synthetized and biologically evaluated. Studies have been performed in order to compare the effect of tetrazole derivatives bearing amine ...
Unveiling the Potential of BenzylethyleneAryl–Urea Scaffolds for the Design of New Onco Immunomodulating Agents
(MDPI, 2023)
This work focuses on the development of thirteen benzylethylenearyl ureas and one
carbamate. After the synthesis and purification of the compounds, we studied their antiproliferative action on cell lines, such as HEK-293, ...
Pulsed laser fragmentation synthesis of carbon quantum dots (CQDs) as fluorescent probes in non-enzymatic glucose detection
(Elsevier, 2024-08-30)
Pulsed laser fragmentation in liquid (PLFL) is one of the synthesis routes for producing high-purity carbon quantum dots (CQDs) with less toxic by-products in a straightforward system. The limited literature regarding the ...
Synthesis and structural characterization of CaMg0.5CoxNi0.5-xSi2O6 (0 ≤ x ≤ 0.5) solid solutions as a colouring substance
(Elsevier Ltd, 2024-03-13)
In this study, CaMg0.5CoxNi0.5-xSi2O6 (0.0 ≤ x ≤ 0.5) solid solutions with a diopside structure were prepared to reduce the cobalt and nickel amounts compared to M2SiO4 or MgMSiO4 (M = Co, Ni) compounds or CaCoxNi1-xSi2O6 ...