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Self-assembled multivalent (SAMul) ligand systems with enhanced stability in the presence of human serum
(Royal Society of Chemistry, 2019)
Self-assembled cationic micelles are an attractive platform for binding biologically-relevant polyanions such as heparin. This has potential applications in coagulation control, where a synthetic heparin rescue agent could ...
Synthesis of combretastatin A-4 O-alkyl derivatives and evaluation of their cytotoxic, antiangiogenic and antitelomerase activity
(Elsevier, 2013-12)
We here report the synthesis and biological evaluation of several combretastatin A-4 derivatives alkylated at the phenol hydroxyl group. Some of these derivatives contain an (E)-arylalkene fragment reminiscent of that ...
Stereoselective synthesis of a C1-C18 fragment of amphidinolides G and H
(Elsevier, 2013-04)
A stereoselective synthesis of a C1–C18 segment of the structure of the cytotoxic macrolides amphidinolides G and H is reported. The target compound was retrosynthetically disconnected into three fragments. In the synthetic ...
Monitoring psychoactive substance use at six European festivals through wastewater and pooled urine analysis
(Elsevier, 2020-07-10)
The consumption of psychoactive substances is considered a growing problem in many communities. Moreover, new psychoactive substances (NPS) designed as (legal) substitutes to traditional illicit drugs are relatively easily ...
Synthesis and Crystal Structure of 1-(4-Nitrobenzyl)-3-allyl-1H-benzo[d]imidazol-2(3H)-one
(Hindawi Publishing Corporation, 2013)
A functionalized benzimidazole, 1-(4-nitrobenzyl)-3-allyl-1H-benzo[d]imidazol-2(3H)-one, has been synthesized, and the crystal structure was determined and analyzed. This compound crystallizes in the monoclinic, space group ...
Assessment of tropospheric ozone effects on citrus crops using passive samplers in a western Mediterranean area
(Elsevier, 2008)
This work assesses the effects caused by tropospheric ozone on citric crops in "La Plana de Castellon", a western Mediterranean area rich in orange orchards. Passive ozone samplers were used as an alternative tool to monitor ...
Small Molecules as Toll-like Receptor 4 Modulators Drug and In-House Computational Repurposing
(MDPI, 2022-09)
The innate immunity toll-like receptor 4 (TLR4) system is a receptor of paramount importance as a therapeutic target. Virtual screening following a “computer-aided drug repurposing” approach was applied to the discovery ...
Synthesis of heterocycles compounds from condensation of limonene with aldehydes using heteropolyacids supported on metal oxides
(Elsevier, 2022-08)
In this contribution, heterogeneous materials based on heteropolyacids (HPA, H3PW12040 hydrate) supported over several metal oxides (TiO2, SiO2, SBA-15, Al2O3) were prepared using wetness impregnation, characterized by ...
New chiral tetraaza ligands for the efficient enantioselective addition of dialkylzinc to aromatic aldehydes
(Elsevier, 2008)
A series of chiral tetraaza ligands were studied for the enantioselective addition of dialkylzinc to aldehydes. These bis(amino amide) ligands show high enantioselectivity in the addition of organozincs to aromatic aldehydes. ...
Mujeres en, por y para la ciencia
(Universitat Jaume I. Institut Universitari d’Investigació Feminista i de gènere, 2010)