ListarDepartament: Química Inorgànica i Orgànica por tema "triazole"

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    • openAccess   Aryl azoles based scaffolds for disrupting tumor microenvironment 

      Pla López, Alberto; Martinez-Colomina, Paula; Cañada-García, Laura; Fuertes-Monge, Laura; Orellana-Palacios, Jose C.; Valderrama-Martínez, Alejandro; Pérez Sosa, Marikena; Carda, Miguel; Falomir, Eva Elsevier (2023-11-15)
      Thirty-nine aryl azoles, thirteen triazoles and twenty-seven tetrazoles, have been synthetized and biologically evaluated to determine their activity as tumor microenvironment disruptors. Antiproliferative studies have ...

    • openAccess   Continuous-Flow Supercritical CO2 Platform for In-Situ Synthesis and Purification of Small Molecules for Drug Discovery 

      Alcalde, Sergio; Porcar Garcia, Raul; De la Puente, María Luz; Cumming, Graham; Mateos, Carlos; García-Losada, Pablo; Anta, Cristina; Rincón, Juan A.; Garcia-Verdugo, Eduardo American Chemical Society (2023-02-03)
      The use of supercritical CO2 (scCO2) as an enabling technology paves the way for an efficient in-line integration of the synthesis and purification of organic molecules. The scCO2 platform presented here provides a ...