• openAccess   Aryl azoles based scaffolds for disrupting tumor microenvironment 

      Pla López, Alberto; Martinez-Colomina, Paula; Cañada-García, Laura; Fuertes-Monge, Laura; Orellana-Palacios, Jose C.; Valderrama-Martínez, Alejandro; Pérez Sosa, Marikena; Carda, Miguel; Falomir, Eva Elsevier (2023-11-15)
      Thirty-nine aryl azoles, thirteen triazoles and twenty-seven tetrazoles, have been synthetized and biologically evaluated to determine their activity as tumor microenvironment disruptors. Antiproliferative studies have ...
    • openAccess   Tetrazole derivatives as potent immunomodulatory agents in tumor microenvironment 

      Pla López, Alberto; Carda, Miguel; Falomir, Eva Elsevier (2023-11-01)
      Twenty-seven compounds bearing a tetrazole ring as a central unit have been designed, synthetized and biologically evaluated. Studies have been performed in order to compare the effect of tetrazole derivatives bearing amine ...