Listar FCA_Articles por autoría "dd1bce14-85f6-4142-a860-68b0c7973515"
Mostrando ítems 1-6 de 6
-
African Swine Fever Virus Gene B117L Encodes a Small Protein Endowed with Low-pH-Dependent Membrane Permeabilizing Activity
Gladue, Douglas; Gómez Lucas, Lidia; Largo, Eneko; Velazquez-Salinas, Lauro; Ramirez-Medina, Elizabeth; Torralba, Johana; Queralt-Martin, Maria; Alcaraz, Antonio; Nieva, Jose L; Borca, Manuel V. American Society for Microbiology (2023-05-22)African swine fever virus (ASFV) is causing a devastating pandemic in domestic and wild swine in Central Europe to East Asia, resulting in economic losses for the swine industry. The virus contains a large double-stranded ... -
Ion channel activity of the CSFV p7 viroporin in surrogates of the ER lipid bilayer
Largo, Eneko; Verdiá Báguena, Carmen; Aguilella, Vicente; Nieva, José L.; Alcaraz, Antonio Elsevier (2016-01)Viroporins comprise a family of non-structural proteins that play significant and diverse roles during the replication cycle of many animal viruses. Consequently, they have become promising targets for inhibitory drug and ... -
Molecular Characterization of the Viroporin Function of Foot-and-Mouth Disease Virus Nonstructural Protein 2B
Gladue, Douglas; Largo, Eneko; de la Arada, Igor; Aguilella, Vicente; Alcaraz, Antonio; Arrondo, Jose Luis; Holinka, L.G.; Brocchi, Emiliana; Ramirez-Medina, Elizabeth; Vuono, Elizabeth; Berggren, Keith; Carrillo, C.; Nieva, Jose L; Borca, Manuel V. American Society for Microbiology (2018-12)Nonstructural protein 2B of foot-and-mouth disease (FMD) virus (FMDV) is comprised of a small, hydrophobic, 154-amino-acid protein. Structure-function analyses demonstrated that FMDV 2B is an ion channel-forming protein. ... -
Mutation-induced changes of transmembrane pore size revealed by combined ion-channel conductance and single vesicle permeabilization analyses
Largo, Eneko; Gladue, Douglas; Torralba, Johana; Aguilella, Vicente; Alcaraz, Antonio; Borca, Manuel V.; Nieva, José L. Elsevier (2018-05)Permeabilization of the Endoplasmic Reticulum (ER) is instrumental in the progression of host-cell infection by many viral pathogens. We have described that permeabilization of ER model membranes by the pore-forming domain ... -
Single-molecule conformational dynamics of viroporin ion channels regulated by lipid-protein interactions
Largo, Eneko; Queralt-Martín, María; Carravilla Palomanes, Pablo; Nieva, José L.; Alcaraz, Antonio Elsevier (2020-02)Classic swine fever is a highly contagious and often fatal viral disease that is caused by the classical swine fever virus (CSFV). Protein p7 of CFSV is a prototype of viroporin, a family of small, highly hydrophobic ... -
The P. aeruginosa effector Tse5 forms membrane pores disrupting the membrane potential of intoxicated bacteria
González Magaña, Amaia; Altuna, Jon; Queralt-Martín, María; Largo, Eneko; Velázquez, Carmen; Montánchez, Itxaso; Bernal, Patricia; Alcaraz, Antonio; Albesa-Jové, David Nature Research (2022)The type VI secretion system (T6SS) of Pseudomonas aeruginosa injects effector proteins into neighbouring competitors and host cells, providing a fitness advantage that allows this opportunistic nosocomial pathogen to ...