Education modulates the association of the FTO rs9939609 polymorphism with body mass index and obesity risk in the Mediterranean population
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Otros documentos de la autoría: Corella, Dolores; Carrasco, Paula; Sorlí, José V; Coltell, Oscar; CAROLINA, ORTEGA-AZORÍN; Guillen, Montserrat; González, José I.; Sáiz, Carmen; Estruch, Ramon; Ordovás Muñoz, José M.
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INVESTIGACIONMetadatos
Título
Education modulates the association of the FTO rs9939609 polymorphism with body mass index and obesity risk in the Mediterranean populationAutoría
Fecha de publicación
2012Editor
ElsevierISSN
0939-4753Cita bibliográfica
D. Corella, P. Carrasco, J.V. Sorlí, O. Coltell, C. Ortega-Azorín, M. Guillén, J.I. González, C. Sáiz, R. Estruch, J.M. Ordovas, Education modulates the association of the FTO rs9939609 polymorphism with body mass index and obesity risk in the Mediterranean population, Nutrition, Metabolism and Cardiovascular Diseases, Volume 22, Issue 8, August 2012, Pages 651-658, ISSN 0939-4753Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
http://www.sciencedirect.com/science/article/pii/S0939475310002401Versión
info:eu-repo/semantics/acceptedVersionPalabras clave / Materias
Resumen
Objective
To define whether the rs9939609 FTO (fat mass and obesity associated) single nucleotide polymorphism (SNP) is associated with anthropometric measurements and its modulation by educational level in a ... [+]
Objective
To define whether the rs9939609 FTO (fat mass and obesity associated) single nucleotide polymorphism (SNP) is associated with anthropometric measurements and its modulation by educational level in a Mediterranean population.
Methods
We studied 3 independent adult samples: a random sample (n = 1580) from the general population (GP), obese hospital patients (OHP) (n = 203) and elderly subjects (n = 1027) with high cardiovascular risk (HCR). Weight and height were directly measured. Education and physical activity (PA) were measured using questionnaires.
Results
The rs9939609 presented heterogeneous associations with BMI. In the GP, the minor A-allele was significantly associated with greater BMI, following a co-dominant pattern (P = 0.009), whereas in the OHP this association was recessive (P = 0.004). Conversely, we did not find a significant association with BMI in the HCR group (P < 0.596). In the GP we found a significant interaction between the FTO SNP and education (P = 0.048). In the stratified analysis, no association of the FTO SNP with greater BMI in university subjects was detected (P = 0.786), whereas the association was observed in non-university subjects (P = 0.001). The FTO × education interaction (P = 0.020) was also observed in determining obesity risk in the GP. A-allele carriers had a greater risk of being obese only if they had no university education (OR: 1.56; 95%CI: 1.09–2.23 for TA and OR: 2.01; 95%CI: 1.27–3.26 for AA subjects). The interaction of the FTO with education remained significant even after adjustment for PA. [-]
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Nutrition, Metabolism and Cardiovascular Diseases (2012) 22 (8)Derechos de acceso
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