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dc.contributor.authorRandall, Patrick A.
dc.contributor.authorPardo Andrés, Marta
dc.contributor.authorNunes, Eric J.
dc.contributor.authorLópez Cruz, Laura
dc.contributor.authorVemuri, Venkata Kiran
dc.contributor.authorMakriyannis, Alexandros
dc.contributor.authorBaqi, Younis
dc.contributor.authorMüller, Christa E.
dc.contributor.authorCorrea, Merce
dc.contributor.authorSalamone, John
dc.date.accessioned2013-05-24T15:58:08Z
dc.date.available2013-05-24T15:58:08Z
dc.date.issued2012
dc.identifier.issn1932-6203
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/10234/64533
dc.description.abstractMesolimbic dopamine (DA) is involved in behavioral activation and effort-related processes. Rats with impaired DA transmission reallocate their instrumental behavior away from food-reinforced tasks with high response requirements, and instead select less effortful food-seeking behaviors. In the present study, the effects of several drug treatments were assessed using a progressive ratio (PROG)/chow feeding concurrent choice task. With this task, rats can lever press on a PROG schedule reinforced by a preferred high-carbohydrate food pellet, or alternatively approach and consume the lesspreferred but concurrently available laboratory chow. Rats pass through each ratio level 15 times, after which the ratio requirement is incremented by one additional response. The DA D2 antagonist haloperidol (0.025–0.1 mg/kg) reduced number of lever presses and highest ratio achieved but did not reduce chow intake. In contrast, the adenosine A2A antagonist MSX-3 increased lever presses and highest ratio achieved, but decreased chow consumption. The cannabinoid CB1 inverse agonist and putative appetite suppressant AM251 decreased lever presses, highest ratio achieved, and chow intake; this effect was similar to that produced by pre-feeding. Furthermore, DA-related signal transduction activity (pDARPP-32(Thr34) expression) was greater in nucleus accumbens core of high responders (rats with high lever pressing output) compared to low responders. Thus, the effects of DA antagonism differed greatly from those produced by prefeeding or reduced CB1 transmission, and it appears unlikely that haloperidol reduces PROG responding because of a general reduction in primary food motivation or the unconditioned reinforcing properties of food. Furthermore, accumbens core signal transduction activity is related to individual differences in work outputca_CA
dc.format.extent10 p.ca_CA
dc.format.mimetypeapplication/pdfca_CA
dc.language.isoengca_CA
dc.publisherPublic Library of Scienceca_CA
dc.relation.isPartOfPLoS ONE, October, Volume 7, Issue 10, e47934ca_CA
dc.rights© 2012 Randall et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are creditedca_CA
dc.rights.urihttp://creativecommons.org/licenses/by-sa/4.0/
dc.titleDopaminergic modulation of effort-related choice behavior as assessed by a progressive ratio chow feeding choice task: pharmacological studies and the role of individual differencesca_CA
dc.typeinfo:eu-repo/semantics/articleca_CA
dc.identifier.doihttp://dx.doi.org/10.1371/journal.pone.0047934
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessca_CA
dc.relation.publisherVersionhttp://www.plosone.org/article/fetchObject.action?uri=info%3Adoi%2F10.1371%2Fjournal.pone.0047934&representation=PDFca_CA
dc.type.versioninfo:eu-repo/semantics/publishedVersionca_CA


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© 2012 Randall et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits
unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
Excepto si se señala otra cosa, la licencia del ítem se describe como: © 2012 Randall et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited