Kinetic analysis for macrocyclizations involving anionic template at the transition state
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Título
Kinetic analysis for macrocyclizations involving anionic template at the transition stateFecha de publicación
2012Editor
Hindawi Publishing CorporationTipo de documento
info:eu-repo/semantics/articlePalabras clave / Materias
Resumen
Several kinetic models for the macrocyclization of a
C
2
pseudopeptide with a dihalide through a
S
N
2
... [+]
Several kinetic models for the macrocyclization of a
C
2
pseudopeptide with a dihalide through a
S
N
2
reaction have been developed. These models not only focus on the kinetic analysis of the main macrocyclization reaction, but also consider the
competitive oligomerization/polymerization processes yielding undesired oligomeric/polymeric byproducts. The effect of anions has also been included in the kinetic models, as they can act as catalytic templates in the transition state reducing and stabilizing the transition state. The corresponding differential equation systems for each kinetic model can be solved numerically. Through a comprehensive analysis of these results, it is possible to obtain a better understanding of the different parameters that are involved in the macrocyclization reaction mechanism and to develop strategies for the optimization of the desired processes. [-]
Publicado en
The Scientific World Journal Volume 2012 (2012), Article ID 748251Derechos de acceso
info:eu-repo/semantics/openAccess
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