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Synthesis and biological properties of the cytotoxic 14-membered macrolides aspergillide A and B

dc.contributor.authorDiaz-Oltra, Santiago
dc.contributor.authorAngulo-Pachón, César A.
dc.contributor.authorMurga, Juan
dc.contributor.authorFalomir, Eva
dc.contributor.authorCarda, Miguel
dc.contributor.authorMarco, J. Alberto
dc.date.accessioned2012-11-02T13:36:15Z
dc.date.available2012-11-02T13:36:15Z
dc.date.issued2010-11-09
dc.identifier.urihttp://hdl.handle.net/10234/50879
dc.description.abstractTotal, stereoselective syntheses of the naturally occurring, cytotoxic macrolides aspergillide A and B are described. Olefin metatheses and asymmetric allylations were key steps in the synthetic sequences. Cytotoxicity assays against several tumor cell lines have been performed for the two aspergillides and some of the intermediates or side products of the synthetic sequence. One of these intermediates has been found markedly active against the human leukemia cancer cell line HL-60, with an IC50 value comparable with that of the clinical drug fludarabine.ca_CA
dc.format.extent14 p.ca_CA
dc.language.isoengca_CA
dc.publisherWileyca_CA
dc.rights.urihttp://rightsstatements.org/vocab/CNE/1.0/*
dc.subjectAntitumor agentsca_CA
dc.subjectAsymmetric allylationca_CA
dc.subjectCytotoxicityca_CA
dc.subjectMacrolidesca_CA
dc.subjectOlefin metathesisca_CA
dc.subject.lcshAntineoplastic agentsca_CA
dc.subject.lcshMacrolidesca_CA
dc.subject.otherCitotoxicitatca_CA
dc.subject.otherMetàtesi (Química)ca_CA
dc.titleSynthesis and biological properties of the cytotoxic 14-membered macrolides aspergillide A and Bca_CA
dc.typeinfo:eu-repo/semantics/articleca_CA
dc.identifier.doihttp://dx.doi.org/10.1002/chem.201001682
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccessca_CA


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