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Rapid and sensitive determination of nicotine in formulations and biological fluid using micellar liquid chromatography with electrochemical detection
dc.contributor.author | Chin-Chen, Mei Liang | |
dc.contributor.author | Rambla Alegre, María | |
dc.contributor.author | Durgbanshi, Abhilasha | |
dc.contributor.author | Bose, Devasish | |
dc.contributor.author | Esteve-Romero, Josep | |
dc.date.accessioned | 2012-10-22T11:17:33Z | |
dc.date.available | 2012-10-22T11:17:33Z | |
dc.date.issued | 2010 | |
dc.identifier | http://dx.doi.org/10.1016/j.jchromb.2010.07.010 | |
dc.identifier.citation | Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 878, 26, p. 2397-2402 | |
dc.identifier.issn | 15700232 | |
dc.identifier.uri | http://hdl.handle.net/10234/49401 | |
dc.description.abstract | Nicotine can be determined in pharmaceuticals and biological fluids by micellar liquid chromatography (MLC) using a C18 column, a mobile phase containing sodium dodecyl sulphate 0.15M-6% (v/v) pentanol-NaH<sub>2</sub>PO<sub>4</sub> 0.01M (pH 6)-KCl 0.001M, with electrochemical detection at 0.8V. In the optimization step, the influence of the modifiers propanol, butanol and pentanol, and the voltage has been studied. With the proposed method the analysis time is below than 8min, linearity better than 0.999, limits of detection and quantification (ng/ml) was 4 and 12 respectively, repeatability and intermediate precision below 1.8%, and all these parameters are adequate for the quantification of nicotine in chewing gum, dermal patches, tobacco and serum samples either by a pharmacologist, pathologist or toxicologist. © 2010 Elsevier B.V. | |
dc.language.iso | eng | |
dc.publisher | Elsevier | |
dc.rights.uri | http://rightsstatements.org/vocab/CNE/1.0/ | * |
dc.subject | Direct injection | |
dc.subject | Electrochemical detector | |
dc.subject | Micellar liquid chromatography | |
dc.subject | Nicotine | |
dc.title | Rapid and sensitive determination of nicotine in formulations and biological fluid using micellar liquid chromatography with electrochemical detection | |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | http://dx.doi.org/10.1016/j.jchromb.2010.07.010 | |
dc.rights.accessRights | info:eu-repo/semantics/restrictedAccess | |
dc.type.version | info:eu-repo/semantics/publishedVersion |
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