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Gas chromatography coupled to high-resolution time-of-flight mass spectrometry to analyze trace-level organic compounds in the environment, food safety and toxicology
dc.contributor.author | Hernandez, Felix | |
dc.contributor.author | Portoles, Tania | |
dc.contributor.author | Pitarch, Elena | |
dc.contributor.author | Lopez, Francisco | |
dc.date.accessioned | 2012-09-05T11:10:28Z | |
dc.date.available | 2012-09-05T11:10:28Z | |
dc.date.issued | 2011 | |
dc.identifier.citation | TrAC Trends in Analytical Chemistry (Feb. 2011), vol. 30, no. 2, p. 388-400 | |
dc.identifier.issn | 0165-9936 | |
dc.identifier.uri | http://hdl.handle.net/10234/46023 | |
dc.description.abstract | Gas chromatography coupled to high-resolution time-of flight mass spectrometry (GC-HR-TOF-MS) is a powerful analytical technique with excellent capabilities due to its high sensitivity in full-spectrum-acquisition mode together with its resolving power and accurate-mass measurements. These features make this technique very attractive in qualitative analysis, especially for wide-scope screening of a large number of organic contaminants and residues at trace levels. Full-spectrum MS allows data processing, in principle, of an unlimited number of compounds in samples, as no analyte-specific information is required before the injection. Also, as all data remain available, retrospective analysis is always possible without the need to reinject the sample – an important advantage of full-spectrum MS techniques. Despite these advantages, GC-HR-TOF-MS has rarely been applied, so we expect promising results in different applied fields in the years ahead. We discuss in detail the characteristics and the potential of GC-HR-TOF-MS. We describe different analytical strategies from wide-scope target screening to investigation of unknowns in biology, the environment and food safety. Recent instrumental developments (e.g., high-speed analog-to-digital converter or soft ionization sources) and advances in software for processing the huge amount of data available open up new prospects, making GC-TOF-MS one of the most promising techniques to investigate the presence of organic compounds in different fields. | ca_CA |
dc.format.extent | 13 p. | ca_CA |
dc.format.mimetype | application/pdf | ca_CA |
dc.language | eng | ca_CA |
dc.language.iso | cat | ca_CA |
dc.publisher | Elsevier | ca_CA |
dc.rights | © 2011 Elsevier Inc. All rights reserved | ca_CA |
dc.rights.uri | http://rightsstatements.org/vocab/InC/1.0/ | * |
dc.subject | Biological sample | ca_CA |
dc.subject | Drug of abuse | ca_CA |
dc.subject | Environment | ca_CA |
dc.subject | Food safety | ca_CA |
dc.subject | Gas chromatography | ca_CA |
dc.subject | High resolution | ca_CA |
dc.subject | Mass spectrometry | ca_CA |
dc.subject | Non-target screening | ca_CA |
dc.subject | Target screening | ca_CA |
dc.subject | Time of flight | ca_CA |
dc.subject | Water | ca_CA |
dc.title | Gas chromatography coupled to high-resolution time-of-flight mass spectrometry to analyze trace-level organic compounds in the environment, food safety and toxicology | ca_CA |
dc.type | info:eu-repo/semantics/article | ca_CA |
dc.identifier.doi | http://dx.doi.org/10.1016/j.trac.2010.11.007 | |
dc.rights.accessRights | info:eu-repo/semantics/restrictedAccess | ca_CA |
dc.relation.publisherVersion | http://www.sciencedirect.com/science/article/pii/S0165993610003432 | ca_CA |
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