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Functional magnetic resonance imaging correlates of cognitive performance in patients with a clinically isolated syndrome suggestive of multiple sclerosis at presentation: an activation and connectivity study
dc.contributor.author | Forn, Cristina | |
dc.contributor.author | Rocca, Maria Assunta | |
dc.contributor.author | Valsasina, Paola | |
dc.contributor.author | Boscá, Isabel | |
dc.contributor.author | Casanova, Bonaventura | |
dc.contributor.author | Sanjuán Tomás, Ana | |
dc.contributor.author | Avila, Cesar | |
dc.contributor.author | Filippi, Massimo | |
dc.date.accessioned | 2012-06-13T07:24:08Z | |
dc.date.available | 2012-06-13T07:24:08Z | |
dc.date.issued | 2012-02 | |
dc.identifier.citation | Multiple Sclerosis Journal (Febr. 2012), vol. 18, no. 2, 153-163 | ca_CA |
dc.identifier.issn | 1352-4585 | |
dc.identifier.issn | 1477-0970 | |
dc.identifier.uri | http://hdl.handle.net/10234/41543 | |
dc.description.abstract | Background/Objective: To assess whether abnormalities on functional magnetic resonance imaging (fMRI) are related to cognitive function in patients at presentation with clinically isolated syndrome (CIS) suggestive of multiple sclerosis. Methods: Eighteen patients with CIS and 15 healthy controls (HCs) performed an adapted fMRI version of the Paced Auditory Serial Addition Test (PASAT). According to their PASAT performance, CIS patients were divided into two groups: 10 with a low PASAT performance (<1 SD from the mean value of HCs) were considered ‘cognitive impairment’ (CI); eight patients were defined as ‘cognitively preserved’ (CP). Between-group differences in the patterns of brain activations and effective connectivity were assessed. Results: During PASAT, compared to HCs, CIS patients showed increased activations of the bilateral inferior parietal lobe (IPL), bilateral precuneus, bilateral middle frontal gyrus (MFG), left anterior cingulate cortex (ACC), left claustrum, right thalamus and right caudate nucleus. When CIS patients were analyzed, the CI group had a more significant activation of the bilateral IPL than HCs and CP patients. Compared to CP patients, they also had more significant recruitment of the right superior parietal lobe, right cerebellum, left MFG and left ACC. The analysis of effective connectivity showed stronger connections between several regions of the right hemisphere involved in working memory function in CI patients versus CP and HC. Conclusions: During performance of the PASAT, CIS patients show abnormalities in the patterns of cortical recruitment and connectivity related to the level of their cognitive impairment. | ca_CA |
dc.description.sponsorShip | This research has been supported by the following grants: Alicia Koplowitz Foundation; CSD2007-00012 (Consolider-Ingenio 2010 Programme), SEJ2007-65929/PSIC and PSI2010-20168 from the Spanish Ministry of Science and Education; the Dávalos Foundation Grant and P1·1A2010-07 from Bancaixa. | ca_CA |
dc.format.extent | 27 p. | ca_CA |
dc.format.mimetype | application/pdf | ca_CA |
dc.language.iso | eng | ca_CA |
dc.publisher | Sage | ca_CA |
dc.relation.isFormatOf | Versió pre-print del document publicat a: http://msj.sagepub.com/content/18/2/153 | ca_CA |
dc.rights | Copyright © 2012 by SAGE Publications | ca_CA |
dc.rights.uri | http://rightsstatements.org/vocab/InC/1.0/ | * |
dc.subject | MRI | ca_CA |
dc.subject | Multiple sclerosis | ca_CA |
dc.subject | T2 lesions | ca_CA |
dc.title | Functional magnetic resonance imaging correlates of cognitive performance in patients with a clinically isolated syndrome suggestive of multiple sclerosis at presentation: an activation and connectivity study | ca_CA |
dc.title.alternative | Functional MRI correlates of cognitive performance in patients with a clinically isolated syndrome suggestive of MS at presentation: an activation and connectivity study | ca_CA |
dc.type | info:eu-repo/semantics/article | ca_CA |
dc.identifier.doi | http://dx.doi.org/10.1177/1352458511417744 | |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | ca_CA |
dc.type.version | info:eu-repo/semantics/submittedVersion | ca_CA |
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