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Dopamine/adenosine interactions related to locomotion and tremor in animal models: Possible relevance to parkinsonism
dc.contributor.author | Salamone, John | |
dc.contributor.author | Ishiwari, K. | |
dc.contributor.author | Betz, Adrienne J. | |
dc.contributor.author | Farrar, Andrew M. | |
dc.contributor.author | Mingote, Susana | |
dc.contributor.author | Font Hurtado, Laura | |
dc.contributor.author | Hockemeyer, J. | |
dc.contributor.author | Müller, Christa E. | |
dc.contributor.author | Correa, Merce | |
dc.date.accessioned | 2012-05-28T14:36:46Z | |
dc.date.available | 2012-05-28T14:36:46Z | |
dc.date.issued | 2008 | |
dc.identifier | http://dx.doi.org/10.1016/j.parkreldis.2008.04.017 | |
dc.identifier.citation | Parkinsonism and Related Disorders, 14, SUPPL.2 | |
dc.identifier.issn | 13538020 | |
dc.identifier.uri | http://hdl.handle.net/10234/39014 | |
dc.description.abstract | Adenosine A<sub>2A</sub> antagonists can exert antiparkinsonian effects in animal models. Recent experiments studied the ability of MSX-3 (an adenosine A<sub>2A</sub> antagonist) to reverse the locomotor suppression and tremor produced by dopamine antagonists in rats. MSX-3 reversed haloperidol-induced suppression of locomotion, and reduced the tremulous jaw movements induced by haloperidol, pimozide, and reserpine. Infusions of MSX-3 into the nucleus accumbens core increased locomotion in haloperidol-treated rats, but there were no effects of infusions into the accumbens shell or ventrolateral neostriatum. In contrast, MSX-3 injected into the ventrolateral neostriatum reduced pimozide-induced tremulous jaw movements. Dopamine/adenosine interactions in different striatal subregions are involved in distinct aspects of motor function. © 2008 Elsevier Ltd. All rights reserved. | |
dc.language.iso | eng | |
dc.publisher | Elsevier | |
dc.rights.uri | http://rightsstatements.org/vocab/InC/1.0/ | * |
dc.subject | Antipsychotic | |
dc.subject | Basal ganglia | |
dc.subject | Caudate | |
dc.subject | Dopamine | |
dc.subject | Motivation | |
dc.subject | Motor | |
dc.subject | Neostriatum | |
dc.subject | Nucleus accumbens | |
dc.subject | Parkinson's disease | |
dc.subject | Putamen | |
dc.title | Dopamine/adenosine interactions related to locomotion and tremor in animal models: Possible relevance to parkinsonism | |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | http://dx.doi.org/10.1016/j.parkreldis.2008.04.017 | |
dc.rights.accessRights | info:eu-repo/semantics/restrictedAccess | |
dc.type.version | info:eu-repo/semantics/submittedVersion | ca_CA |
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