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Evaluating the impact of a training program in shared decision-making for neurologists treating people with migraine
(Springer Nature, 2023-06-13)
Introduction :
Migraine symptoms vary significantly between patients and within the same patient. Currently, an increasing number of therapeutic options are available for symptomatic and preventive treatment. Guidelines ...
Endoderm development requires centrioles to restrain p53-mediated apoptosis in the absence of ERK activity
(Elsevier, 2021-12-20)
Centrioles comprise the heart of centrosomes, microtubule-organizing centers. To study the function of centrioles in lung and gut development, we genetically disrupted centrioles throughout the mouse endoderm. Surprisingly, ...
Rapid degeneration of iPSC-derived motor neurons lacking Gdap1 engages a mitochondrial-sustained innate immune response
(Springer Nature, 2023-07-01)
Charcot-Marie-Tooth disease is a chronic hereditary motor and sensory polyneuropathy targeting Schwann cells and/or motor neurons. Its multifactorial and polygenic origin portrays a complex clinical phenotype of the disease ...
P2X4 signalling contributes to hyperactivity but not pain sensitization comorbidity in a mouse model of attention deficit/hyperactivity disorder
(Frontiers Media, 2024)
Introduction: Attention deficit/hyperactivity disorder (ADHD) is a common
neurodevelopmental disorder characterized by hyperactivity, inattention, and
impulsivity that often persist until adulthood. Frequent comorbid ...
Pacing and Body Weight Changes During a Mountain Ultramarathon: Sex Differences and Performance
(SciendoAcademy of Physical Education in Katowice, 2021)
The study was aimed at comparing pacing adopted by males and females in a 107-km mountain ultramarathon
and assessing whether pacing-related variables were associated with intracompetition body weight changes and
performance. ...
Nucleus incertus projections to rat medial septum and entorhinal cortex: rare collateralization and septal-gating of temporal lobe theta rhythm activity
(Springer, 2023)
Nucleus incertus (NI) neurons in the pontine tegmentum give rise to ascending forebrain projections and express the neuropeptide relaxin-3 (RLN3) which acts via the relaxin-family peptide 3 receptor (RXFP3). Activity in ...
Comparison of IOTA three-step strategy and logistic regression model LR2 for discriminating between benign and malignant adnexal masses
(Romanian Society for Ultrasonography in Medicine and Biology (SRUMB), 2021)
Aims: To compare the diagnostic performance of two ultrasound-based diagnostic systems for the classification of benign or malignant adnexal masses, the three-step strategy and the predictive logistic regression model LR2, ...
Novel Tissue-Engineered Multimodular Hyaluronic Acid-Polylactic Acid Conduits for the Regeneration of Sciatic Nerve Defect
(MDPI, 2022-05)
The gold standard for the treatment of peripheral nerve injuries, the autograft, presents several drawbacks, and engineered constructs are currently suitable only for short gaps or small diameter nerves. Here, we study a ...
Neoadjuvant Chemotherapy plus Interval Cytoreductive Surgery with or without Hyperthermic Intraperitoneal Chemotherapy (NIHIPEC) in the Treatment of Advanced Ovarian Cancer: A Multicentric Propensity Score Study
(MDPI, 2023-08-26)
Simple Summary Advanced ovarian cancer (Stages III-IV) continues to be one of the gynecological tumors with the highest mortality. Standard treatment consists of debulking surgery and subsequent adjuvant chemotherapy. ...
Should We Abandon Intraperitoneal Chemotherapy in the Treatment of Advanced Ovarian Cancer? A Meta-Analysis
(MDPI, 2023-11-23)
Background: Ovarian cancer is the gynaecological malignancy with the highest mortality and diagnosis often occurs in its advanced stages. Standard treatment in these cases is based on complete cytoreductive surgery with ...