Browsing MED_Articles by Issue Date

Now showing items 81-100 of 657

    • closedAccess   Lipoic acid lessens Th1-mediated inflammation in lipopolysaccharide-induced uveitis reducing selectively Th1 lymphocytes-related cytokines release 

      Mérida, S.; Sancho Tello, M.; Muriach Saurí, María; Miranda, M.; Navea, A.; Bosch Morell, F. Informa HealthCare (2013-08)
      Infl ammation results in the production of free radicals. We evaluated the anti-infl ammatory and antioxidant capacity of lipoic acid in an experimental uveitis model upon a subcutaneous injection of endotoxin into Lewis ...

    • closedAccess   Persistent phagocytic characteristics of microglia in the substantia nigra of long-term Parkinsonian macaques 

      Barcia, Carlos; Ros Gómez, Carmen María; Ros Bernal, Francisco; Gómez, Aurora; Annese, Valentina; Carrillo de Sauvage, María Ángeles; Yuste Jiménez, José Enrique; Campuzano Brando, Carmen María; De Pablos, Vicente; Fernández Villalba, Emiliano; Herrero Ezquerro, María Trinidad Elsevier (2013-08)
      Patients with Parkinson's disease show persistent microglial activation in the areas of the brain where the degeneration of dopaminergic neurons takes place. The reason for maintaining this activated state is still unknown, ...

    • closedAccess   Potent and multiple regulatory actions of microglial glucocorticoid receptors during CNS inflammation 

      Carrillo de Sauvage, María Ángeles; Maatouk, L.; Arnoux, I.; Pasco, M.; Sanz Díez, A.; Delahaye, M.; Herrero Ezquerro, María Trinidad; Newman, T.A.; Calvo, C.F.; Audinat, E.; Tronche, F.; Vyas, S. Nature Publishing Group (2013-09)
      In CNS, glucocorticoids (GCs) activate both GC receptor (GR) and mineralocorticoid receptor (MR), whereas GR is widely expressed, the expression of MR is restricted. However, both are present in the microglia, the resident ...

    • closedAccess   Gender differences in the neurotoxicity of metals in children 

      Llop, Sabrina; López Espinosa, María José; Rebagliato, Marisa; Ballester, Ferran Elsevier (2013-09)
      Gender-related differences in susceptibility to chemical exposure to neurotoxicants have not received sufficient attention. Although a significant number of epidemiological studies on the neurodevelopmental effects of metal ...

    • closedAccess   Of Pheromones and Kairomones: What Receptors Mediate Innate Emotional Responses? 

      Fortes Marco, Lluís; Lanuza, Enrique; Martinez-Garcia, Fernando Wiley (2013-09)
      Some chemicals elicit innate emotionally laden behavioral responses. Pheromones mediate sexual attraction, parental care or agonistic confrontation, whereas predators' kairomones elicit defensive behaviors in their preys. ...

    • closedAccess   ER stress in human hepatic cells treated with Efavirenz: Mitochondria again 

      Apostolova, Nadezda; Gómez Sucerquia, Leysa J.; Alegre, Fernando; Funes, Haryes A.; Víctor, Víctor M.; Barrachina Sancho, María Dolores; Blas García, Ana; Esplugues Mota, Juan V. Elsevier (2013-10)
      Background & Aims ER stress is associated with a growing number of liver diseases, including drug-induced hepatotoxicity. The non-nucleoside analogue reverse transcriptase inhibitor Efavirenz, a cornerstone of the ...

    • closedAccess   Maternal Smoking During Pregnancy and Fetal Biometry: The INMA Mother and Child Cohort Study 

      Iñiguez, Carmen; Ballester, Ferran; Costa, Olga; Murcia, Mario; Souto, Ana; SANTA MARINA, LORETO; Aurrekoetxea, J. J.; Espada, Mercedes; Vrijheid, Martine; Álvarez Avellón, Sara M.; Álvarez Pedrerol, Mar; Rebagliato, Marisa Oxford University Press (2013-10-01)
      In utero tobacco exposure has been associated with fetal growth restriction, but uncertainty remains about critical windows of exposure and specific effects on body segments. In the present study, we aimed to examine the ...

    • closedAccess   Current status of ovarian cancer in the Spanish Province of Castellon. Prognostic factors in observed and relative survival. A population cancer-registry-based study between 2004 and 2008 

      Llueca, Antoni; Martinez-Ramos, David; Escrig-Sos, Javier; Torrella-Ramos, Ana; Herraiz Roda, José Luis; Serra Rubert, Anna; Queralt-Martín, Raquel; Salvador-Sanchis, Jose Luis; Calpe Gómez, Enrique Elsevier España (2014)
      Background: The aim of this population-based study was to assess independent prognostic factors in ovarian cancer by analyzing observed and relative survival in a representative Spanish population. Methods: We carried ...

    • openAccess   The importance of socio-legal interventions in the case management of a severe dual pathology program: our 6 years’ experience 

      Haro, Gonzalo; Baquero Escribano, Abel; Traver, Francisco; Real-López, Matias (2014)

    • openAccess   Diabetes and the brain: oxidative stress, inflammation, and autophagy 

      Muriach Saurí, María; Flores-Bellver, Miguel; Romero, Francisco J.; Barcia, Jorge M Hindawi Publishing Corporation (2014)
      Diabetes mellitus is a common metabolic disorder associated with chronic complications including a state of mild to moderate cognitive impairment, in particular psychomotor slowing and reduced mental flexibility, not ...

    • closedAccess   Functional role of Barrington’s nucleus in the micturition reflex: Relevance in the surgical treatment of Parkinson’s disease 

      Herrero Ezquerro, María Trinidad; Blanco, Lisette; Ros Gómez, Carmen María; Tarragon Cros, Ernesto; Fernández Villalba, Emiliano Elsevier (2014)
      The pontine micturition center or Barrington’s nucleus (BN) – besides regulating micturition – co-regulates the activity of other pelvic viscera such as the colon and genitals. At present, this issue is gaining particular ...

    • openAccess   New GOLD classification: longitudinal data on group assignment 

      Casanova, Ciro; Marin, Jose M.; Martinez-Gonzalez, Cristina; Lucas-Ramos, Pilar de; Mir-Viladrich, Isabel; Cosio, Borja; Peces-Barba, Germán; Calle-Rubio, Miryam; Solanes-García, Ingrid; Agüero Balbin, Ramón; de Diego, Alfredo; Feu-Collado, Nuria; Alfageme Michavila, Inmaculada; Irigaray, Rosa; Balcells, Eva; Llunell Casanovas, Antònia; Bautista i García, Joan Damià; Marín Royo, Margarita; Soler-Cataluña, Juan J.; Lopez-Campos, Jose Luis; Soriano, Joan B.; Torres, Juan P. de; COPD History Assessment In SpaiN (CHAIN) cohort BioMed Central (2014)
      Rationale: Little is known about the longitudinal changes associated with using the 2013 update of the multidimensional GOLD strategy for chronic obstructive pulmonary disease (COPD). Objective: To determine the COPD ...

    • closedAccess   Chronic Cocaine Effects in Retinal Metabolism and Electrophysiology: Treatment with Topiramate 

      Sánchez-Villarejo, María V.; López-Pedrajas, Rosa; Sánchez Vallejo, Violeta; Genovés, José M.; Muriach Saurí, María; Barcia, Jorge M; Romero, Francisco J. Informa Healthcare (2014)
      Purpose: Cocaine abuse is a major public health problem with multiple-related complications. Indeed, cocaine can affect almost every organ of the human body, but little is known about its effects on the visual system. The ...

    • openAccess   Non-compliance and therapeutic inertia: two unanswered questions in clinical practice 

      Pallarés-Carratalá, Vicente; Pascual Pérez, R. Informa Healthcare (2014)

    • closedAccess   Gender and eye colour prediction discrepancies: A reply to criticisms (letter) 

      Martinez-Cadenas, Conrado; Peña Chilet, María; Llorca-Cardeñosa, Marta J.; Cervera, Raimundo; Ibarrola-Villava, Maider; Ribas, Gloria Elsevier (2014)
      Letter to the editor: In a letter published in this same issue, Liu et al. reply to a recently published article by us contesting the main conclusion of our original paper, namely, that gender is a factor that contributes to ...

    • openAccess   The Interplay between Natural Selection and Susceptibility to Melanoma on Allele 374F of SLC45A2 Gene in a South European Population 

      López, Saioa; García, Oscar; Yurrebaso, Iñaki; Flores, Carlos; Acosta-Herrera, Marialbert; Chen, Hua; Gardeazabal, Jesús; Careaga, Jesús María; Boyano, Dolores; Sánchez, Ana; Ratón-Nieto, Juan Antonio; Sevilla, Arrate; Smith-Zubiaga, I.; García de Galdeano, Alicia; Martinez-Cadenas, Conrado; Izagirre, Neskuts; de la Rúa, Concepción; Alonso, Santos Public Library of Science (2014)
      We aimed to study the selective pressures interacting on SLC45A2 to investigate the interplay between selection and susceptibility to disease. Thus, we enrolled 500 volunteers from a geographically limited population ...

    • openAccess   Treatment adherence and other patient-reported outcomes as cost determinants in multiple sclerosis: a review of the literature 

      Lizán, Luis; Comellas, Marta; Paz, Silvia; Poveda, José Luis; Meletiche, Dennis M.; Polanco, Carlos Dove Medical Press (2014)
      Background: Treatment adherence is one of the key factors for achieving optimal clinical outcomes. In order to assess costs related to adherence to, and persistence and compliance with, disease-modifying therapies (DMTs) ...

    • openAccess   Polymorphisms in ABC Transporter Genes and Concentrations of Mercury in Newborns – Evidence from Two Mediterranean Birth Cohorts 

      Llop, Sabrina; Engström, Karin; Ballester, Ferran; Franforte, Elisa; Alhamdow, Ayman; Pisa, Federica; Tratnik, Janja Snoj; Mazej, Datja; Murcia, Mario; Rebagliato, Marisa; Bustamante, Mariona; Sunyer Deu, Jordi; Sofianou-Katsoulis, Aikaterini; Prasouli, Alexia; Antonopoulou, Eleni; Antoniadou, Ioanna; Nakou, Sheena; Barbone, Fabio; Horvat, Milena; Broberg, Karin Public Library of Science (2014)
      Background: The genetic background may influence methylmercury (MeHg) metabolism and neurotoxicity. ATP binding cassette (ABC) transporters actively transport various xenobiotics across biological membranes. Objective: ...

    • openAccess   Matching Diabetes and Alcoholism: Oxidative Stress, Inflammation, and Neurogenesis Are Commonly Involved 

      Barcia, Jorge M; Flores-Bellver, Miguel; Muriach Saurí, María; Sancho Pelluz, Francisco Javier; Lopez-Malo, Daniel; Urdaneta, Alba C.; Martinez-Gil, Natalia; Atienzar-Aroca, Sandra; Romero, Francisco J. Hindawi Publishing Corporation (2014)
      Diabetes and alcohol misuse are two of the major challenges in health systems worldwide. These two diseases finally affect several organs and systems including the central nervous system. Hippocampus is one of the most ...

    • closedAccess   Exposure to mercury among Spanish preschool children: Trend from birth to age four 

      Llop, Sabrina; Murcia, Mario; Aguinagalde, Xabier; Vioque, Jesus; Rebagliato, Marisa; Cases, Amparo; Iñiguez, Carmen; López Espinosa, María José; Amurrio, Ascensión; Navarrete-Muñoz, Eva María; Ballester, Ferran Elsevier (2014)
      The purpose of this study is to describe the total hair mercury concentrations and their determinants in preschool Spanish children, as well as to explore the trend in mercury exposure from birth to the age four. This ...