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Metalloproteinase-9 contributes to inflammatory glia activation and nigro-striatal pathway degeneration in both mouse and monkey models of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinsonism
Springer (2014-02)Inflammation is a predominant aspect of neurodegenerative diseases, manifested by glia activation and expression of pro-inflammatory mediators. Studies on animal models of Parkinson’s disease (PD) suggest that sustained ... -
Microbiological Characterization of the Biofilms Colonizing Bioplastics in Natural Marine Conditions: A Comparison between PHBV and PLA
MDPI (2023)Biodegradable polymers offer a potential solution to marine pollution caused by plastic waste. The marine biofilms that formed on the surfaces of poly(lactide acid) (PLA) and poly(3- hydroxybutyrate-co-3-hydroxyvalerate) ... -
Mitochondrial (dys)function-a factor underlying the variability of EFV-induced hepatoxicity?
Wiley (2015-01-08)Background and PurposeThe non-nucleoside analogue reverse transcriptase inhibitor efavirenz is associated with hepatic toxicity and metabolic disturbances. Although the mechanisms involved are not clear, recent evidence ... -
Mobile learning en la anatomía humana: estudio del mercado de aplicaciones
Elsevier (2022-05-02)Introduction Mobile applications for human anatomy learning are a mobile learning format that can contribute to the training of Health Sciences students. The aim of this study is to analyze the human anatomy learning ... -
Modelo predictivo clínico-radiológico para diagnosticar tuberculosis pulmonar activa
Sociedad Chilena de Radiología (2019)El objetivo de este estudio fue desarrollar un modelo predictivo sobre la presencia de tuberculosis pulmonar activa utilizando datos clínico-epidemiológicos y hallazgos de radiografía simple (Rx) y tomografía computadorizada ... -
Modulation of contextual fear acquisition and extinction by acute and chronic relaxin-3 receptor (RXFP3) activation in the rat retrosplenial cortex
Elsevier (2024-07)The retrosplenial cortex (RSC) plays a central role in processing contextual fear conditioning. In addition to corticocortical and thalamocortical projections, the RSC receives subcortical inputs, including a substantial ... -
Modulation of forebrain function by nucleus incertus and relaxin-3/RXFP3 signaling
Wiley (2018)The nucleus incertus (NI) in the pontine tegmentum sends ascending projections to the midbrain, hypothalamus, amygdala, basal forebrain, hippocampus, and prefrontal cortex, and has a postulated role in modulating several ... -
Molecular Strategies for Targeting Antioxidants to Mitochondria: Therapeutic Implications
Mary Ann Liebert (2015-03-10)Mitochondrial function and specifically its implication in cellular redox/oxidative balance is fundamental in controlling the life and death of cells, and has been implicated in a wide range of human pathologies. In this ... -
Monomania of drunkenness by Géricault
Elsevier (2022-09) -
Morphological and chemical characterisation of indoor quasi-ultrafine particles
Elsevier (2024-02-01)Particles in the nanoscale range have intrinsic physicochemical characteristics that define their interaction with the human body and ultimately their toxicity. Whilst research has focused on engineered nanomaterials or ... -
Mortality and cardiovascular disease burden of uncontrolled diabetes in a registry-based cohort: the ESCARVAL-risk study
BMC (2018-09-04)Background: Despite the epidemiological evidence about the relationship between diabetes, mortality and cardiovascular disease, information about the population impact of uncontrolled diabetes is scarce. We aimed to ... -
Mother's education and the risk of preterm and small for gestational age birth: a DRIVERS meta-analysis of 12 European cohorts
BMJ Publishing Group (2015-04-24)Background A healthy start to life is a major priority in efforts to reduce health inequalities across Europe, with important implications for the health of future generations. There is limited combined evidence on ... -
Motherhood-induced gene expression in the mouse medial amygdala: Changes induced by pregnancy and lactation but not by pup stimuli
Federation of American Society of Experimental Biology (2021)During lactation, adult female mice display aggressive responses toward male intrud-ers, triggered by male- derived chemosensory signals. This aggressive behavior is not shown by pup- sensitized virgin females sharing ... -
MUC1 deficiency mediates corticosteroid resistance in chronic obstructive pulmonary disease
BMC (2018)Background Lung inflammation in COPD is poorly controlled by inhaled corticosteroids (ICS). Strategies to improve ICS efficacy or the search of biomarkers who may select those patients candidates to receive ICS in COPD ... -
MUC4 impairs the anti-inflammatory effects of corticosteroids in patients with chronic rhinosinusitis with nasal polyps
Elsevier (2016)Background Current evidence suggests that membrane-tethered mucins could mediate corticosteroid efficacy, interacting with glucocorticoid receptor (GR) in patients with chronic rhinosinusitis with nasal polyps (CRSwNP). ... -
MUC4 is overexpressed in idiopathic pulmonary fibrosis and collaborates with transforming growth factor β inducing fibrotic responses
Springer Nature (2020-09-04)Several mucins are implicated in idiopathic pulmonary fibrosis (IPF); however, there is no evidence regarding the role of MUC4 in the development of IPF. Here we demonstrated that MUC4 was overexpressed in IPF patients ... -
Mucin 1 deficiency mediates corticosteroid insensitivity in asthma
Wiley (2019-01)BACKGROUND: The loss of corticosteroid efficacy is an important issue in severe asthma management and may lead to poor asthma control and deterioration of airflow. Recent data indicate that Mucin 1 (MUC1) membrane mucin ... -
Multidisciplinary expert consensus on secondary fracture prevention in Spain
Springer (2021-02-27)Summary The study aimed to achieve expert consensus to optimize secondary fracture prevention in Spain. Relevant gaps in current patient management were identified. However, some aspects were considered difficult to apply. ... -
Multidisciplinary management of cardiovascular disease in women: Delphi consensus
Frontiers (2024)Background: Current clinical guidelines on cardiovascular disease (CVD) do not specifically address the female population. The aim of this consensus is to know the opinion of a group of experts on the management of CVD ... -
Multimodular Bio-Inspired Organized Structures Guiding Long-Distance Axonal Regeneration
MDPI (2022-09)Axonal bundles or axonal tracts have an aligned and unidirectional architecture present in many neural structures with different lengths. When peripheral nerve injury (PNI), spinal cord injury (SCI), traumatic brain injury ...