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Mostrando ítems 101-120 de 657

    • openAccess   Is the Physician’s Behavior in Dyslipidemia Diagnosis in Accordance with Guidelines? Cross-Sectional Escarval Study 

      Palazón-Bru, Antonio; Gil-Guillén, Vicente F; Orozco Beltrán, Domingo; Pallarés-Carratalá, Vicente; Valls Roca, Francisco; Sanchis-Domenech, Carlos; Martin-Moreno, Jose M.; Redón, Josep; Navarro Pérez, Jorge; Fernández Giménez, Antonio; Pérez Navarro, Ana M.; Trillo, José L.; Usó, Ruth; Ruiz, Elías Public Library of Science (2014)
      Background: Clinical inertia has been defined as mistakes by the physician in starting or intensifying treatment when indicated. Inertia, therefore, can affect other stages in the healthcare process, like diagnosis. The ...

    • openAccess   Alpha-Theta effects associated with ageing during the stroop test 

      Nombela, Cristina; Nombela, Manuel; Castell, Pedro; García, Teodoro; López Coronado, Juan; Herrero Ezquerro, María Trinidad Public Library of Science (2014)
      The Stroop effect is considered as a standard attentional measure to study conflict resolution in humans. The response of the brain to conflict is supposed to change over time and it is impaired in certain pathological ...

    • openAccess   Involvement of ANXA5 and ILKAP in Susceptibility to Malignant Melanoma 

      Santos, Alonso; Ribas, Gloria; Ibarrola-Villava, Maider; Peña Chilet, María; Martinez-Cadenas, Conrado; Gardeazabal, Jesús; Careaga, Jesús María; Pérez-Yarza, Gorka; Sánchez-Díez, Ana; Ratón-Nieto, Juan Antonio; Arroyo-Berdgo, Yoana; Carretero, Gregorio; Martín González, Manuel; Gómez Fernández, Cristina; Nagore, Eduardo; Asumendi, Aintzane; Boyano, Dolores Public Library of Science (2014)
      Single nucleotide-polymorphisms (SNPs) are a source of diversity among human population, which may be responsible for the different individual susceptibility to diseases and/or response to drugs, among other phenotypic ...

    • openAccess   An anti-interleukin-2 receptor drug attenuates thelper 1 lymphocytes-mediated inflammation in an acute model of endotoxin-induced uveitis 

      Mérida, S.; Sancho Tello, M.; Navea, A.; Almansa, Inmaculada; Muriach Saurí, María; Bosch Morell, F. Public Library of Science (2014)
      The aim of the present study was to evaluate the anti-inflammatory efficacy of Daclizumab, an anti-interleukin-2 receptor drug, in an experimental uveitis model upon a subcutaneous injection of lipopolysaccharide into ...

    • closedAccess   Long telomere length and a TERT-CLPTM1 locus polymorphism association with melanoma risk 

      Llorca-Cardeñosa, Marta J.; Peña Chilet, María; Mayor, Matías; Gómez Fernández, Cristina; Casado, Beatriz; Martín González, Manuel; Carretero, Gregorio; Lluch , Ana; Martinez-Cadenas, Conrado; Ibarrola-Villava, Maider; Ribas, Gloria Elsevier (2014)
      Telomere length has been associated with the development of cancer. Studies have shown that shorter telomere length may be related to a decreased risk of cutaneous melanoma. Furthermore, deregulation of the telomere-maintaining ...

    • openAccess   Dislipidemia y riesgo vascular. Una revisión basada en nuevas evidencias 

      Pallarés-Carratalá, Vicente; Pascual Fuster, V.; Godoy Rocati, D. Elsevier (2014-01)
      La dislipidemia es uno de los principales factores de riesgo de cardiopatía isquémica, primera causa de mortalidad en el mundo. Realizar una detección temprana y una intervención terapéutica precoz son elementos clave a ...

    • closedAccess   Using exomarkers to assess mitochondrial reactive species in vivo 

      Logan, Angela; Cochemé, Helena M.; Boon Li Pun, Pamela; Apostolova, Nadezda; Smith, Robin A. J.; Larsen, Lesley; Larsen, David S.; James, Andrew M.; Fearnley, Ian M.; Rogatti, Sebastian; Prime, Tracy A.; Finichiu, Peter G.; Dare, Anna; Chouchani, Edward T.; Pell, Victoria R.; Methner, Carmen; Quin, Caroline; McQuaker, Stephen J.; Krieg, Thomas; Hartley, Richard C.; Murphy, Michael P. Elsevier (2014-02)
      Background The ability to measure the concentrations of small damaging and signalling molecules such as reactive oxygen species (ROS) in vivo is essential to understanding their biological roles. While a range of methods ...

    • closedAccess   Focal lesions within the ventral striato-pallidum abolish attraction for male chemosignals in female mice 

      Agustín-Pavón, Carmen; Martinez-Garcia, Fernando; Lanuza, Enrique Elsevier (2014-02)
      In rodents, socio-sexual behaviour is largely mediated by chemosensory cues, some of which are rewarding stimuli. Female mice display an innate attraction towards male chemosignals, dependent on the vomeronasal system. ...

    • openAccess   Metalloproteinase-9 contributes to inflammatory glia activation and nigro-striatal pathway degeneration in both mouse and monkey models of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinsonism 

      Annese, Valentina; Herrero Ezquerro, María Trinidad; Di Pentima, M.; Gómez, Aurora; Lombardi, L.; Ros Gómez, Carmen María; De Pablos, Vicente; Fernández Villalba, Emiliano; De Stefano, Maria Egle Springer (2014-02)
      Inflammation is a predominant aspect of neurodegenerative diseases, manifested by glia activation and expression of pro-inflammatory mediators. Studies on animal models of Parkinson’s disease (PD) suggest that sustained ...

    • closedAccess   Factors associated with second-hand smoke exposure in non-smoking pregnant women in Spain: Self-reported exposure and urinary cotinine levels 

      Aurrekoetxea, J. J.; Murcia, Mario; Rebagliato, Marisa; Fernández Somoano, Ana; Miren Castlla, Ane; Guxens, Mònica; López Espinosa, María José; Lertxundi, Aitana; Espada, Mercedes; Tardon, Adonina; Ballester, Ferran; SANTA MARINA, LORETO Elsevier (2014-02)
      The aim of this study was to evaluate the main sources of and sociodemographic factors associated with second-hand smoke (SHS) exposure, assessed both by questionnaire and by urinary cotinine (UC) levels, in non-smoking ...

    • openAccess   Focal Lesions within the ventral striato-pallidum abolish attraction for male chemosignals in female mice 

      Agustín-Pavón, Carmen; Martinez-Garcia, Fernando; Lanuza, Enrique Elsevier (2014-02)
      In rodents, socio-sexual behaviour is largely mediated by chemosensory cues, some of which are rewarding stimuli. Female mice display an innate attraction towards male chemosignals, dependent on the vomeronasal system. ...

    • openAccess   El control de brotes de tos ferina en las escuelas 

      Arnedo Pena, Alberto; Romeu García, M. Angeles; Bellido-Blasco, Juan Bautista; Pardo Serrano, Francisco Elsevier (2014-03)

    • closedAccess   Principales factores asociados al coste de la diabetes mellitus tipo 2: revisión de la literatura 

      Paz, Silvia; González Segura, Diego; Raya Torres, Anna; Lizán, Luis Elsevier (2014-04)
      Objective: To analyze the main factors that influence the health care costs of treating type 2 diabetes mellitus (T2DM) patients, using a literature review. Methods: National and international electronic data bases ...

    • openAccess   Neuronal Bioenergetics and Acute Mitochondrial Dysfunction: A Clue to Understanding the Central Nervous System Side Effects of Efavirenz 

      Funes, Haryes A.; Apostolova, Nadezda; Alegre, Fernando; Blas García, Ana; Álvarez, Ángeles; Martí Cabrera, Miguel; Esplugues Mota, Juan V. Oxford University Press (2014-05)
      Background. Neurological pathogenesis is associated with mitochondrial dysfunction and differences in neuronal/glial handling of oxygen and glucose. The main side effects attributed to efavirenz involve the CNS, but the ...

    • closedAccess   Extending the socio-sexual brain: arginine-vasopressin immunoreactive circuits in the telencephalon of mice 

      Otero García, Marcos; Martín Sánchez, Ana; Fortes Marco, Lluís; Martínez-Ricós, Joana; Agustín-Pavón, Carmen; Lanuza, Enrique; Martinez-Garcia, Fernando Springer Berlin Heidelberg (2014-05)
      Quantitative analysis of the immunoreactivity for arginine-vasopressin (AVP-ir) in the telencephalon of male (intact and castrated) and female CD1 mice allows us to precisely locate two sexually dimorphic (more abundant ...

    • openAccess   Clinical Application of the COPD Assessment Test: Longitudinal Data From the COPD History Assessment in Spain (CHAIN) Cohort 

      Torres, Juan P. de; Marin, Jose M.; Martinez-Gonzalez, Cristina; Lucas-Ramos, Pilar de; Mir-Viladrich, Isabel; Cosio, Borja; Peces-Barba, Germán; Calle-Rubio, Miryam; Solanes-García, Ingrid; Agüero Balbin, Ramón; Diego-Damia, Alfredo de; Feu-Collado, Nuria; Alfageme Michavila, Inmaculada; Irigaray, Rosa; Balcells, Eva; Llunell Casanovas, Antònia; Galdiz Iturri, Juan Bautista; Marín Royo, Margarita; Soler-Cataluña, Juan J.; Lopez-Campos, Jose Luis; Soriano, Joan B.; Casanova, Ciro Elsevier (2014-07)
      OBJECTIVE: The COPD Assessment Test (CAT) has been proposed for assessing health status in COPD, but little is known about its longitudinal changes. The objective of this study was to evaluate 1-year CAT variability in ...

    • closedAccess   Memantine prevents reference and working memory impairment caused by sleep deprivation in both young and aged Octodon degus 

      Herrero Ezquerro, María Trinidad; Tarragon Cros, Ernesto; López, Dolores; Estrada, Cristina; González Cuello, Ana; Ros Gómez, Carmen María; Lamberty, Yves; Pifferi, Fabien; Cella, Massimo; Canovi, Mara; Guiso, Giovanna; Gobbi, Marco; Fernández Villalba, Emiliano; Blin, Olivier; Bordet, Regis; Richardson, Jill C. Elsevier (2014-10)
      Memory loss is one of the key features of cognitive impairment in either aging, Mild Cognitive Impairment (MCI) or dementia. Pharmacological treatments for memory loss are today focused on addressing symptomatology. One ...

    • closedAccess   A systematic review of neurodevelopmental effects of prenatal and postnatal organophosphate pesticide exposure 

      González Alzaga, B.; Lacasaña, Marina; Aguilar Garduño, Clemente; Rodríguez Barranco, Miguel; Ballester, Ferran; Rebagliato, Marisa Elsevier (2014-10)
      Agricultural and residential use of organophosphate (OP) pesticides has increased in recent decades after banning some persistent pesticides. Although there is evidence of the effects of OPs on neurodevelopment and behaviour ...

    • closedAccess   Is Glycemic Control Modulating Endoplasmic Reticulum Stress in Leukocytes of Type 2 Diabetic Patients? 

      Rovira Llopis, Susana; Bañuls, Celia; Apostolova, Nadezda; Morillas, Carlos; Hernández Mijares, Antonio; Rocha, Milagros; Víctor, Víctor M. Mary Ann Liebert Inc. (2014-10-06)
      Oxidative and endoplasmic reticulum (ER) stress is related to type 2 diabetes (T2D), but the influence of glycemic control on these parameters and its relationship with leukocyte-endothelial interactions is not known. In ...

    • openAccess   Sex pheromones are not always attractive: changes induced by learning and illness in mice 

      Lanuza, Enrique; Martín Sánchez, Ana; Marco Monclús, Pau; Cádiz-Moretti, Bernardita; Fortes Marco, Lluís; Hernández Martínez, Adoración; McLean, Lynn; Beynon, Robert J.; Hurst, Jane L.; Martinez-Garcia, Fernando Elsevier (2014-11)
      A male-specific major urinary protein named darcin is attractive to female mice, Mus musculus, stimulates a learned attraction to volatile components of a male's urinary odour and induces spatial learning. In this article ...