Listar MED_Articles por autoría "e5e99702-6fe7-4e8c-9809-fcd7e637b576"
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JAK2 mediates lung fibrosis, pulmonary vascular remodelling and hypertension in idiopathic pulmonary fibrosis: an experimental study
MILARA, JAVIER; Ballester, Beatriz; Morell, Anselm; Ortiz, José L.; Escrivá, Juan; Fernández, Estrella; Pérez-Vizcaino, Francisco; Cogolludo, Ángel; Pastor, Enrique; Artigues, Enrique; Morcillo, Esteban; Cortijo, Julio BMJ (2018)Background Pulmonary hypertension (PH) is a common disorder in patients with idiopathic pulmonary fibrosis (IPF) and portends a poor prognosis. Recent studies using vasodilators approved for PH have failed in improving IPF ... -
MUC4 is overexpressed in idiopathic pulmonary fibrosis and collaborates with transforming growth factor β inducing fibrotic responses
MILARA, JAVIER; Ballester, Beatriz; Safont, M. J.; Artigues, Enrique; Escrivá, Juan; Morcillo, Esteban; Cortijo, Julio Springer Nature (2020-09-04)Several mucins are implicated in idiopathic pulmonary fibrosis (IPF); however, there is no evidence regarding the role of MUC4 in the development of IPF. Here we demonstrated that MUC4 was overexpressed in IPF patients ... -
The JAK2 pathway is activated in idiopathic pulmonary fibrosis
MILARA, JAVIER; Hernandez, Gracia; Ballester, Beatriz; Morell, Anselm; Roger, Inés; Montero, P.; Escrivá, Juan; Lloris, José M.; Molina Molina, Maria; Morcillo, Esteban; Cortijo, Julio BioMed Central (2018)Background: Idiopathic pulmonary fibrosis (IPF) is the most rapidly progressive and fatal fibrotic disorder, with no curative therapies. The signal transducer and activator of transcription 3 (STAT3) protein is activated ...