Browsing MED_Articles by Author "e026be32-9c53-4a05-b00c-1bfe5e0d1120"
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Beta‐blockers withdrawal in patients with heart failure with preserved ejection fraction and chronotropic incompetence: Effect on functional capacity rationale and study design of a prospective, randomized, controlled trial (The Preserve‐HR trial)
Palau, Patricia; Seller, Julia; Domínguez Mafé, Eloy; Gómez, Inés; Ramón, José María; Sastre, Clara; De la Espriella, Rafael; Santas, Enrique; Miñana, Gema; Chorro, Francisco J.; González Juanatey, José Ramón; Nuñez, Julio Wiley (2020)Background: The pathophysiology of heart failure with preserved ejection fraction (HFpEF) is complex and multifactorial. Chronotropic incompetence (ChI) has emerged as a crucial pathophysiological mechanism. Beta‐blockers, ... -
Chronotropic index and long-term outcomes in heart failure with preserved ejection fraction
Palau, Patricia; Domínguez Mafé, Eloy; Seller, Julia; Sastre, Clara; Sanchis, Juan; López, Laura; Bodí, Vicent; Llàcer, Pau; Miñana, Gema; De la Espriella, Rafael; Bayes-Genis, Antoni; Núñez, Julio Elsevier (2022)Introduction and objectives: Little is known about the usefulness of heart rate (HR) response to exercise for risk stratification in heart failure with preserved ejection fraction (HFpEF). Therefore, this study aimed ... -
Dapagliflozin and short-term changes on circulating antigen carbohydrate 125 in heart failure with reduced ejection fraction
Amiguet, Martina; Palau, Patricia; Domínguez Mafé, Eloy; Seller, Julia; GARCIA-PINILLA, JOSE MANUEL; De la Espriella, Rafael; Miñana, Gema; Valle, Alfonso; Sanchis, Juan; Górriz, José Luis; Bayes-Genis, Antoni; DAPA-VO2 Investigators, /; Núñez, Julio Nature Research (2023)Circulating antigen carbohydrate 125 (CA125) has emerged as a proxy of fluid overload in heart failure. This study aimed to evaluate the effect of dapagliflozin on short-term CA125 levels in patients with stable heart ... -
Early glomerular filtration rate decline is associated with hemoglobin rise following dapagliflozin initiation in heart failure with reduced ejection fraction
Miñana, Gema; De la Espriella, Rafael; Palau, Patricia; Amiguet Comins, Martina; Seller, Julia; García Pinilla, José Manuel; Núñez, Eduardo; Górriz, José Luis; Valle, Alfonso; Sanchis, Juan; Bayés-Genís, Antoni; Núñez, Julio; DAPA-VO2 Investigators, / Elsevier (2023)Introduction and objectives Sodium-glucose cotransporter-2 inhibitors (SGLT2i) induce short-term changes in renal function and hemoglobin. Their pathophysiology is incompletely understood. We aimed to evaluate the ... -
Effect of β-Blocker Withdrawal on Functional Capacity in Heart Failure and Preserved Ejection Fraction
Palau, Patricia; Seller, Julia; Domínguez Mafé, Eloy; Sastre, Clara; Ramón, Jose María; De la Espriella, Rafael; Santas, Enrique; Miñana, Gema; Bodí, Vicent; Sanchis, Juan; Valle, Alfonso; Chorro, F. Javier; Llácer, Pau; Bayes-Genis, Antoni; Núñez, Julio Elsevier (2021-11-15)BACKGROUND Chronotropic incompetence has shown to be associated with a decrease in exercise capacity in heart failure with preserved ejection fraction (HFpEF), yet b-blockers are commonly used in HFpEF despite the lack ... -
Short-term Changes in Hemoglobin and Changes in Functional Status, Quality of Life and Natriuretic Peptides After Initiation of Dapagliflozin in Heart Failure With Reduced Ejection Fraction
Lorenzo, Miguel; Miñana, Gema; Palau, Patricia; Amiguet, Martina; Seller, Julia; García Pinilla, José Manuel; Villar, Sandra; De la Espriella, Rafael; Núñez, Eduardo; Górriz, José Luis; Valle, Alfonso; Bodí, Vicent; Sanchis, Juan; Bayes-Genis, Antoni; Núñez, Julio; DAPA-VO2 Investigators Elsevier (2023-05)Background: We aimed to evaluate the effect of dapagliflozin on short-term changes in hemoglobin in patients with stable heart failure with reduced ejection fraction (HFrEF) and whether these changes mediated the effect ... -
Short-term effects of dapagliflozin on maximal functional capacity in heart failure with reduced ejection fraction (DAPA-VO2): a randomized clinical trial
Palau, Patricia; Amiguet Comins, Martina; Domínguez Mafé, Eloy; Sastre, Clara; Mollar, Anna; Seller, Julia; GARCIA-PINILLA, JOSE MANUEL; Larumbe, Ainoha; Valle, Alfonso; Gómez Doblas, Juan José; De la Espriella, Rafael; Miñana, Gema; Robles Mezcua, Ainhoa; Santas, Enrique; Bodí, Vicent; Sanchis, Juan; Pascual-Figal, Domingo A.; Gorriz, Jose Luis; Bayes-Genis, Antoni; Núñez, Julio Wiley (2022-05-23)Aims This study aimed to evaluate the effect of dapagliflozin on 1 and 3-month maximal functional capacity in patients with stable heart failure with reduced ejection fraction (HFrEF). Methods and results In this ... -
β-Blocker Withdrawal and Functional Capacity Improvement in Patients With Heart Failure With Preserved Ejection Fraction
Palau, Patricia; De la Espriella, Rafael; Seller, Julia; Santas, Enrique; Domínguez Mafé, Eloy; VV.AA. American Medical Association (2024-02-07)Importance: Increasing the patient's heart rate (HR) has emerged as a therapeutic option in patients with heart failure with preserved ejection fraction (HFpEF). However, the evidence is conflicting, and the profile of ...