Listar MED_Articles por autoría "b527d993-678d-4182-9b2e-83b6b4edf736"
Mostrando ítems 1-7 de 7
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Adenosine A(2A) and A(2B) Receptors Differentially Modulate Keratinocyte Proliferation: Possible Deregulation in Psoriatic Epidermis
Andrés, Rosa M.; Terencio, María Carmen; Arasa, Jorge; Payá, Miquel; Valcuende-Cavero, Francisca; Navalón, Pedro; Montesinos, María Carmen Elsevier (2017-01)Adenosine is a potent regulator of inflammation and immunity, but the role of adenosine receptors in keratinocytes remains controversial. We determined that in addition to A2B receptors, human epidermal keratinocytes also ... -
Association between several immune response-related genes and the effectiveness of biological treatments in patients with moderate-to-severe psoriasis
Loras Monfort, Alba; Gil-Barrachina, Marta; Hernando, Barbara; Pérez-Pastor, Gemma María; Martinez-Domenech, Alvaro; Mahiques, Laura; PITARCH BORT, GERARD; Valcuende-Cavero, Francisca; Ballester, Rosa; Marques-Torrejon, Maria Angeles; Martinez-Cadenas, Conrado Wiley (2024-01-04)Biological therapies are safer and more effective against psoriasis than conventional treatments. Even so, 30–50% of psoriatic patients show an inadequate response, which is associated with individual genetic heterogeneity. ... -
Defective Induction of COX-2 Expression by Psoriatic Fibroblasts Promotes Pro-inflammatory Activation of Macrophages
Arasa, Jorge; Terencio, M. Carmen; Andrés, Rosa M.; Marín Castejón, María Asunción; Valcuende-Cavero, Francisca; Payá, Miguel; Montesinos, M. Carmen Frontiers Media (2019-03-20)Fibroblasts play an important role as members of the innate immune system through the secretion of COX-2-derived inflammatory mediators such as prostaglandin E2 (PGE2). However, it has been described that dermal fibroblasts ... -
Genetic variants associated with skin photosensitivity in a southern European population from Spain
Hernando, Barbara; Sanz-Page, Elena; PITARCH BORT, GERARD; Mahiques, Laura; Valcuende-Cavero, Francisca; Martinez-Cadenas, Conrado Wiley (2018)Background/Purpose: Recent GWAS studies, mostly performed in populations of North European origin, have identified the genetic loci associated with pigmentation, sun sensitivity, freckling and skin cancer ... -
Improved effectiveness from individualized dosing of self-administered biologics for the treatment of moderate-to-severe psoriasis: a 5-year retrospective chart review from a Spanish University Hospital
Sanz-Gil, Roser; Pellicer, Antonio; Montesinos, M. Carmen; Valcuende-Cavero, Francisca Taylor & Francis (2019-04)Background: Biologics for moderate-to-severe psoriasis are expensive and treatment substitutions may vastly increase cost. Moreover, administration regimens in routine practice may differ from recommended guidelines. ... -
Sun exposure and PDZK1 genotype modulate PDZK1 gene expression in normal skin
Hernando, Barbara; Ibarrola-Villava, Maider; Oltra, Sara S.; Valcuende-Cavero, Francisca; PITARCH BORT, GERARD; Mahiques, Laura; Ribas, Gloria; Martinez-Cadenas, Conrado Wiley (2020)Human skin pigmentation results from the enzymatically controlled synthesis of melanin pigments in specialized organelles (melano‐somes) produced within epidermal melanocytes, followed by their transfer to neighboring ... -
The effect of age on the acquisition and selection of cancer driver mutations in sun-exposed normal skin
Hernando, Barbara; Dietzen, M.; Parra, G.; Gil-Barrachina, Marta; PITARCH BORT, GERARD; Mahiques, Laura; Valcuende-Cavero, Francisca; McGranahan, Nicholas; Martinez-Cadenas, Conrado Elsevier (2021)Background: The accumulation of somatic mutations contributes to ageing and cancer. Sunlight is the principal aetiological factor associated with skin cancer development. However, genetic and phenotypic factors also ...