Listar MED_Articles por autoría "a7568d88-0bcb-4f93-9ef8-73aba624365d"
Mostrando ítems 1-20 de 32
-
AAV delivery of shRNA against IRS1 in GABAergic neurons in rat hippocampus impairs spatial memory in females and male rats
Sánchez-Sarasúa, Sandra; Ribes-Navarro, Alberto; Beltrán Bretones, María Teresa; Sánchez-Pérez, Ana María Springer (2020-11-27)Brain insulin resistance is a major factor leading to impaired cognitive function and it is considered as the onset of Alzheimer´s disease. Insulin resistance is intimately linked to inflammatory conditions, many studies ... -
Abscisic Acid Supplementation Rescues High Fat Diet-Induced Alterations in Hippocampal Inflammation and IRSs Expression
Ribes-Navarro, Alberto; Atef, Mariam; Sánchez-Sarasúa, Sandra; Beltrán Bretones, María Teresa; Olucha-Bordonau, Francisco E; Sánchez-Pérez, Ana María Springer (2018)Accumulated evidence indicates that neuroinflammation induces insulin resistance in the brain. Moreover, both processes are intimately linked to neurodegenerative disorders, including Alzheimer’s disease. Potential mechanisms ... -
Abscisic acid, a promising therapeutic molecule to prevent Alzheimer’s and neurodegenerative diseases
Sánchez-Pérez, Ana María Medknow Publications (2020) -
Accelerated Polyethylene Terephthalate (PET) Enzymatic Degradation by Room Temperature Alkali Pre-treatment for Reduced Polymer Crystallinity
Giraldo Narcizo, Sariah de los Angeles; El Guenani Mir, Nihal; Sánchez-Pérez, Ana María; Guerrero, Antonio Wiley (2022-11-07)Polyethylene terephthalate (PET) is the most widely employed plastic for single-use applications. The use of enzymes isolated from microorganisms, such as PETase with the capacity to hydrolyze PET into its monomers, ... -
Acute oral administration of low doses of methylphenidate targets calretinin neurons in the rat septal area
García Avilés, Álvaro; Albert Gasco, Hector; Arnal Vicente, Isabel; Elhajj, Ebtisam; Sanjuán, Julio; Sánchez-Pérez, Ana María; Olucha-Bordonau, Francisco E Frontiers Media (2015)Methylphenidate (MPD) is a commonly administered drug to treat children suffering from attention deficit hyperactivity disorder (ADHD). Alterations in septal driven hippocampal theta rhythm may underlie attention deficits ... -
Adolescent binge‐ethanol accelerates cognitive impairment and β‐amyloid production and dysregulates endocannabinoid signaling in the hippocampus of APP/PSE mice
Ledesma, Juan Carlos; Rodriguez-Arias, Marta; Gavito, Ana Luisa; Sánchez-Pérez, Ana María; Viña, J.; Medina-Vera, Dina; Rodríguez de Fonseca, Fernando; Miñarro, Josse Wiley (2020)Previous research in rodents suggests that the long‐term neurobehavioral disturbances induced by chronic ethanol (EtOH) exposure could be due to endocannabinoid system (ECS) alterations. Moreover, ECS failure has been ... -
Análisis de la expresión y función de los sustratos del receptor de insulina
Valero Ávila, Paola Valentina; Sánchez-Pérez, Ana María Publicacions de la Universitat Jaume I. Servei de Comunicació i Publicacions (2020)La diabetes y la resistencia a insulina están asociada a un mayor riesgo de aparición de enfermedades neurodegenerativas. La señalización de insulina está mediada por los sustratos del receptor de insulina (IRS). ... -
Can We Treat Neuroinflammation in Alzheimer's Disease?
Sánchez-Sarasúa, Sandra; Fernández-Pérez, Iván; Espinosa-Fernández, Verónica; Sánchez-Pérez, Ana María; Ledesma, Juan Carlos MDPI (2020-11-19)Alzheimer’s disease (AD), considered the most common type of dementia, is characterized by a progressive loss of memory, visuospatial, language and complex cognitive abilities. In addition, patients often show comorbid ... -
Central relaxin-3 receptor (RXFP3) activation impairs social recognition and modulates ERK-phosphorylation in specific GABAergic amygdala neurons
Albert Gasco, Hector; Sánchez-Sarasúa, Sandra; Ma, Sherie; García Díaz, Cristina; Gundlach, Andrew Lawrence; Sánchez-Pérez, Ana María; Olucha-Bordonau, Francisco E Springer (2019-01)In mammals, the extended amygdala is a neural hub for social and emotional information processing. In the rat, the extended amygdala receives inhibitory GABAergic projections from the nucleus incertus (NI) in the pontine ... -
Central relaxin-3 receptor (RXFP3) activation increases ERK phosphorylation in septal cholinergic neurons and impairs spatial working memory.
Albert Gasco, Hector; García Avilés, Álvaro; Moustafa, S.; Sánchez-Sarasúa, Sandra; Gundlach, Andrew Lawrence; Olucha-Bordonau, Francisco E; Sánchez-Pérez, Ana María Springer (2016-05-05)The medial septum/diagonal band (MS/DB) is a relay region connecting the hypothalamus and brainstem with the hippocampus, and both the MS/DB and dorsal/ventral hippocampus receive strong topographic GABA/peptidergic ... -
Characterization of serum proteins attached to distinct sol–gel hybrid surfaces
Gomes, Nuno; Romero-Gavilán, Francisco J; Sánchez-Pérez, Ana María; GURRUCHAGA, MARILO; Azkargorta, Mikel; Elortza, Felix; Ibáñez, Maria; Iloro, Ibon; Suay, Julio; Goñi, Isabel Wiley (2017-07)The success of a dental implant depends on its osseointegration, an important feature of the implant biocompatibility. In this study, two distinct sol–gel hybrid coating formulations [50% methyltrimethoxysilane: 50% ... -
Comparative Distribution of Relaxin-3 Inputs and Calcium-Binding Protein-Positive Neurons in Rat Amygdala
Santos, F. N.; Pereira, C. W.; Sánchez-Pérez, Ana María; Otero García, Marcos; Ma, Sherie; Gundlach, Andrew Lawrence; Olucha-Bordonau, Francisco E Frontiers Media (2016)The neural circuits involved in mediating complex behaviors are being rapidly elucidated using various newly developed and powerful anatomical and molecular techniques, providing insights into the neural basis for anxiety ... -
Distribution and targets of the relaxin-3 innervation of the septal area in the rat
Sánchez-Pérez, Ana María; Olucha-Bordonau, Francisco E; Otero García, Marcos; Núñez, Ángel; Ma, Sherie; Gundlach, Andrew Lawrence Wiley-Blackwell (2012)Neural tracing studies have revealed that the rat medial and lateral septum are targeted by ascending projections from the nucleus incertus, a population of tegmental GABA neurons. These neurons express the relaxin-family ... -
Early intervention with ABA prevents neuroinflammation and memory impairment in a triple transgenic mice model of Alzheimer´s disease
Espinosa-Fernández, Verónica; Mañas-Ojeda, Aroa; Pacheco-Herrero, Mar; Castro-Salazar, Ernestina; Ros Bernal, Francisco; Sánchez-Pérez, Ana María Elsevier (2019-11-18)Neuroinflammation and insulin resistance in the brain are intimately linked to neurodegenerative disorders, including Alzheimer’s disease. Even though traditionally Alzheimer´s disease has been associated to Aβ deposits ... -
Electrolytic lesion of the nucleus incertus retards extinction of auditory conditioned fear
Pereira, C. W.; Santos, F. N.; Sánchez-Pérez, Ana María; Otero García, Marcos; Marchioro, M.; Ma, Sherie; Gundlach, Andrew Lawrence; Olucha-Bordonau, Francisco E Elsevier (2013-06-15)Fear memory circuits in the brain function to allow animals and humans to recognize putative sources of danger and adopt an appropriate behavioral response; and research on animal models of fear have helped reveal the ... -
Estudio de la especificidad de vías de insulina/IGF-1 en los patrones de arborización y señalización mediante el uso de virus asociados a adenovirus
Ribes-Navarro, Alberto; Sánchez-Pérez, Ana María Publicacions de la Universitat Jaume I. Servei de Comunicació i Publicacions (2018)Objetivo: Las vías de señalización de insulina y del factor de crecimiento insulínico tipo I(IGF-1) están involucradas en el control de la arborización dendrítica, señalización y crecimientocelular. Varios estudios han ... -
GABAergic Neurons in the Rat Medial Septal Complex Express Relaxin-3 Receptor (RXFP3) mRNA
Albert Gasco, Hector; Ma, Sherie; Ros Bernal, Francisco; Sánchez-Pérez, Ana María; Gundlach, Andrew Lawrence; Olucha-Bordonau, Francisco E Frontiers Media (2018-01-17)The medial septum (MS) complex modulates hippocampal function and related behaviors. Septohippocampal projections promote and control different forms of hippocampal synchronization. Specifically, GABAergic and cholinergic ... -
Glutamine synthetase activity and glutamine content in brain: modulation by NMDA receptors and nitric oxide
Kosenko, Elena; Llansola, Marta; Montoliu, Carmina; Monfort, Pilar; Rodrigo, Regina; Hernández Viadel, Mariluz; Erceg, Slaven; Sánchez-Pérez, Ana María; Felipo, Vicente Elsevier (2003-09)Acute intoxication with large doses of ammonia leads to rapid death. The main mechanism for ammonia elimination in brain is its reaction with glutamate to form glutamine. This reaction is catalyzed by glutamine synthetase ... -
IRS-2 deficiency impairs NMDA receptor-dependent long-term potentiation
Sánchez-Pérez, Ana María; Martín, Eduardo D.; Trejo, José Luis; Martín Aldana, Juan Antonio; Cano Jaimez, Marife; Pons, Sebastian; Acosta Umanzor, Carlos; Menes, Lorena; White, Morris F.; Burks, Deborah J. Oxford University Press (2012-08)The beneficial effects of insulin and insulin-like growth factor I on cognition have been documented in humans and animal models. Conversely, obesity, hyperinsulinemia, and diabetes increase the risk for neurodegenerative ... -
Modulation of forebrain function by nucleus incertus and relaxin-3/RXFP3 signaling
Olucha-Bordonau, Francisco E; Albert Gasco, Hector; Ros Bernal, Francisco; Rytova, Valeria; Ong-Pålsson, Emma K. E.; Ma, Shuai; Sánchez-Pérez, Ana María; Gundlach, Andrew Lawrence Wiley (2018)The nucleus incertus (NI) in the pontine tegmentum sends ascending projections to the midbrain, hypothalamus, amygdala, basal forebrain, hippocampus, and prefrontal cortex, and has a postulated role in modulating several ...