Listar MED_Articles por autoría "96e08d0d-7bd2-4cf2-b414-449a15f38b92"
Mostrando ítems 1-20 de 22
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7-Nitroindazole down-regulates dopamine/DARPP-32 signaling in neostriatal neurons in a rat model of Parkinson's disease
Yuste Jiménez, José Enrique; Echeverry, M. B.; Ros Bernal, Francisco; Gómez, Aurora; Ros Gómez, Carmen María; Campuzano Brando, Carmen María; Fernández Villalba, Emiliano; Herrero Ezquerro, María Trinidad Elsevier (2012)Neuronal nitric oxide synthase (nNOS) is involved in the regulation of diverse intracellular messenger systems in the brain. Nitric Oxide (NO) contributes to inducing signaling cascades that involve a complex pattern of ... -
Caracterización morfológica de la astrogliosis reactiva en el núcleo dorsal del rafe de un modelo 3xTg-AD
Rivero Zaragoza, Eric; Ros Bernal, Francisco Publicacions de la Universitat Jaume I. Servei de Comunicació i Publicacions (2023)Los astrocitos se encargan del funcionamiento óptimo del cerebro y su homeostasis, movilizándose de forma «reactiva» ante lesiones o enfermedades del sistema nervioso central. De esta manera, la astrogliosis reactiva ... -
CCL2-Expressing astrocytes mediate the extravasation of T lymphocytes in the brain. Evidence from patients with glioma and experimental models in vivo
Carrillo-de Sauvage, María Ángeles; Gómez, Aurora; Ros Gómez, Carmen María; Ros Bernal, Francisco; Martín, Eduardo D.; Pérez Vallés, Ana; Gallego Sánchez, José María; Fernández Villalba, Emiliano; Barcia Sr., Carlos; Barcia, Carlos; Herrero Ezquerro, María Trinidad Public Library of Science (2012)CCL2 is a chemokine involved in brain inflammation, but the way in which it contributes to the entrance of lymphocytes in the parenchyma is unclear. Imaging of the cell type responsible for this task and details on how ... -
Dopamine modulation affects the performance of parkinsonian patients in a precision motor task measured by an antropomorphic device
Nombela, Cristina; Pedreño Molina, Juan Luis; Ros Bernal, Francisco; Molina Vilaplana, Javier; Fernández Villalba, Emiliano; López Coronado, Juan; Herrero Ezquerro, María Trinidad Elsevier (2012)Several parameters related to the timing, grip force and load force involved in a precision grasping task were studied in patients with Parkinson’s disease (PD) at different moments of medication and healthy controls, using ... -
Early intervention with ABA prevents neuroinflammation and memory impairment in a triple transgenic mice model of Alzheimer´s disease
Espinosa-Fernández, Verónica; Mañas-Ojeda, Aroa; Pacheco-Herrero, Mar; Castro-Salazar, Ernestina; Ros Bernal, Francisco; Sánchez-Pérez, Ana María Elsevier (2019-11-18)Neuroinflammation and insulin resistance in the brain are intimately linked to neurodegenerative disorders, including Alzheimer’s disease. Even though traditionally Alzheimer´s disease has been associated to Aβ deposits ... -
Effects of pharmacological agents, sleep deprivation, hypoxia and transcranial magnetic stimulation on electroencephalographic rhythms in rodents: Towards translational challenge models for drug discovery in Alzheimer’s disease
Babiloni, Claudio; Infarinato, Francesco; Aujard, Fabienne; Bastlund, Jesper Frank; Bentivoglio, Marina; Bertini, Giuseppe; Del Percio, Claudio; Fabene, Paolo Francesco; Forloni, GianLuigi; Herrero Ezquerro, María Trinidad; Noè, Francesco Mattia; Pifferi, Fabien; Ros Bernal, Francisco; Christensen, Ditte Zerlang; Dix, Sophie; Richardson, Jill C.; Lamberty, Yves; Drinkenburg, Wilhelmus; Rossini, Paolo Maria Elsevier (2013)Different kinds of challenge can alter spontaneous ongoing electroencephalographic (EEG) rhythms in animal models, thus providing paradigms to evaluate treatment effects in drug discovery. The effects of challenges represented ... -
Eficacia analgésica del tratamiento invasivo miofascial (punción seca) en fibromialgia
Vicente Mampel, Juan; Ros Bernal, Francisco Publicacions de la Universitat Jaume I. Servei de Comunicació i Publicacions (2018)Introducción. La fibromialgia (FM) es una entidad clínica caracterizada por un dolorcrónico generalizado. La sensibilización central del sistema nervioso se considera laexplicación más plausible al dolor crónico generalizado ... -
Evidence of oligodendrogliosis in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinsonism
Annese, Valentina; Barcia, Carlos; Ros Bernal, Francisco; Gómez, Aurora; Ros Gómez, Carmen María; De Pablos, Vicente; Fernández Villalba, Emiliano; De Stefano, Maria Egle; Herrero Ezquerro, María Trinidad Wiley (2013)Aims: Mice and nonhuman primates administered with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) represent elective experimental models of Parkinsonism, in which degeneration of the nigrostriatal dopaminergic pathway ... -
Fernando de Castro: Cajal's Man on the Peripheral Nervous System
Ros Bernal, Francisco; De Castro, Fernando Wiley (2019)Santiago Ramón y Cajal developed his initial scientific career working alone. After the publication of his opus magna (“Textura del sistema nervioso del hombre y los vertebrados”) and the general recognition of the scientific ... -
GABAergic Neurons in the Rat Medial Septal Complex Express Relaxin-3 Receptor (RXFP3) mRNA
Albert Gasco, Hector; Ma, Sherie; Ros Bernal, Francisco; Sánchez-Pérez, Ana María; Gundlach, Andrew Lawrence; Olucha-Bordonau, Francisco E Frontiers Media (2018-01-17)The medial septum (MS) complex modulates hippocampal function and related behaviors. Septohippocampal projections promote and control different forms of hippocampal synchronization. Specifically, GABAergic and cholinergic ... -
IFN-c signaling, with the synergistic contribution of TNF-a, mediates cell specific microglial and astroglial activation in experimental models of Parkinson’s disease
Barcia, Carlos; Ros Gómez, Carmen María; Annese, Valentina; Gómez, Aurora; Ros Bernal, Francisco; Aguado Yera, D.; Martínez Pagán, M. E.; De Pablos, Vicente; Fernández Villalba, Emiliano; Herrero Ezquerro, María Trinidad Nature Publishing Group (2011)To through light on the mechanisms underlying the stimulation and persistence of glial cell activation in Parkinsonism, we investigate the function of IFN-c and TNF-a in experimental models of Parkinson’s disease and ... -
Implications of glial nitric oxide in neurodegenerative diseases
Yuste Jiménez, José Enrique; Tarragon Cros, Ernesto; Campuzano Brando, Carmen María; Ros Bernal, Francisco Frontiers Media (2015)Nitric oxide (NO) is a pleiotropic janus-faced molecule synthesized by nitric oxide synthases (NOS) which plays a critical role in a number of physiological and pathological processes in humans. The physiological roles of ... -
Involvement of the Nucleus Incertus and Relaxin-3/RXFP3 Signaling System in Explicit and Implicit Memory
Gil-Miravet, Isis; Mañas-Ojeda, Aroa; Ros Bernal, Francisco; Castillo-Gómez, Esther; Albert Gasco, Hector; Gundlach, Andrew Lawrence; Olucha-Bordonau, Francisco E Frontiers Media (2021-03-18)Telencephalic cognitive and emotional circuits/functions are strongly modulated by subcortical inputs. The main focus of past research on the nature of this modulation has been on the widespread monoamine projections to ... -
Modulation of forebrain function by nucleus incertus and relaxin-3/RXFP3 signaling
Olucha-Bordonau, Francisco E; Albert Gasco, Hector; Ros Bernal, Francisco; Rytova, Valeria; Ong-Pålsson, Emma K. E.; Ma, Shuai; Sánchez-Pérez, Ana María; Gundlach, Andrew Lawrence Wiley (2018)The nucleus incertus (NI) in the pontine tegmentum sends ascending projections to the midbrain, hypothalamus, amygdala, basal forebrain, hippocampus, and prefrontal cortex, and has a postulated role in modulating several ... -
Nigral degeneration correlates with persistent activation of cerebellar Purkinje cells in MPTP-treated monkeys
Heman, Paola; Barcia, Carlos; Gómez, Aurora; Ros Gómez, Carmen María; Ros Bernal, Francisco; Yuste Jiménez, José Enrique; De Pablos, Vicente; Fernández Villalba, Emiliano; Toledo-Cárdenas, María Rebeca; Herrero Ezquerro, María Trinidad Universidad de Murcia (2012)In the present work we analyze the cerebellum of chronic parkinsonian monkeys in order to clarify whether chronic mesencephalic depletion is associated with long term activation of the cerebellar neurons in chronic ... -
Persistent phagocytic characteristics of microglia in the substantia nigra of long-term Parkinsonian macaques
Barcia, Carlos; Ros Gómez, Carmen María; Ros Bernal, Francisco; Gómez, Aurora; Annese, Valentina; Carrillo de Sauvage, María Ángeles; Yuste Jiménez, José Enrique; Campuzano Brando, Carmen María; De Pablos, Vicente; Fernández Villalba, Emiliano; Herrero Ezquerro, María Trinidad Elsevier (2013-08)Patients with Parkinson's disease show persistent microglial activation in the areas of the brain where the degeneration of dopaminergic neurons takes place. The reason for maintaining this activated state is still unknown, ... -
Persistent phagocytic characteristics of microglia in the substantia nigra of long-term Parkinsonian macaques
Barcia, Carlos; Ros Gómez, Carmen María; Ros Bernal, Francisco; Gómez, Aurora; Annese, Valentina; Carrillo-de Sauvage, María Ángeles; Yuste Jiménez, José Enrique; Campuzano Brando, Carmen María; De Pablos, Vicente; Fernández Villalba, Emiliano; Herrero Ezquerro, María Trinidad Elsevier (2013)Patients with Parkinson's disease show persistent microglial activation in the areas of the brain where the degeneration of dopaminergic neurons takes place. The reason for maintaining this activated state is still unknown, ... -
Prospective external validation of IOTA three‐step strategy to characterize and classify adnexal masses and retrospective assessment of an alternative two‐step strategy using simple rules risk
Hidalgo Mora, Juan José; Ros Bernal, Francisco; Aubá, María; Errasti, Tania; Olartecoechea, Begoña; Ruiz-Zambrana, Alvaro; Alcázar Zambrano, J.L. Wiley (2018)OBJECTIVES To perform the external validation of the three‐step strategy proposed by the International Ovarian Tumor Analysis Group to evaluate its diagnostic performance for classifying adnexal masses as benign or ... -
Relación entre neuroinflamación y ovillos neurofibrilares en el hipocampo del modelo 3xtg de la Enfermedad de Alzheimer
Lucerón Morales, Jorge; Ros Bernal, Francisco Publicacions de la Universitat Jaume I. Servei de Comunicació i Publicacions (2023)La Enfermedad de Alzheimer (ea) es el tipo de demencia más común y la mayor pandemia de nuestros tiempos, y afecta en una proporción 2:1 a las mujeres. A nivel clínico implica un deterioro severo en las funciones ... -
Relaxin-3 Innervation From the Nucleus Incertus to the Parahippocampal Cortex of the Rat
García Díaz, Cristina; Gil-Miravet, Isis; Albert Gasco, Hector; Mañas-Ojeda, Aroa; Ros Bernal, Francisco; Castillo-Gómez, Esther; Gundlach, Andrew Lawrence; Olucha-Bordonau, Francisco E Frontiers Media (2021)Spatial learning and memory processes depend on anatomical and functional interactions between the hippocampus and the entorhinal cortex. A key neurophysiological component of these processes is hippocampal theta rhythm, ...