Listar MED_Articles por autoría "3ddd9992-0b80-405c-9d7f-9357ba0212e7"

Mostrando ítems 1-12 de 12

    • openAccess   Ceria nanoparticles with rhodamine B as a powerful theranostic agent against intracellular oxidative stress 

      Apostolova, Nadezda; Rovira Llopis, Susana; Baldoví, Herme G.; Navalón, Sergio; Asiri, Abdullah M.; Víctor, Víctor M.; García, Hermenegildo; Herance, Jose Raul Royal Society of Chemistry (2015-09)
      Ceria nanoparticles with rhodamine B groups covalently attached on their surface (RhB-CeNPs) were successfully prepared to simultaneously exhibit antioxidant activity and the ability to detect oxidant species. In order to ...

    • closedAccess   Efavirenz and the CNS: what we already know and questions that need to be answered 

      Apostolova, Nadezda; Funes, Haryes A.; Blas García, Ana; Galindo, Maria J.; Álvarez, Ángeles; Esplugues, Juan V. Oxford University Press (2015-07)
      The NNRTI efavirenz has long been one of the most frequently employed antiretroviral drugs in the multidrug regimens used to treat HIV infection, in accordance with its well-demonstrated antiretroviral efficacy and ...

    • closedAccess   ER stress in human hepatic cells treated with Efavirenz: Mitochondria again 

      Apostolova, Nadezda; Gómez Sucerquia, Leysa J.; Alegre, Fernando; Funes, Haryes A.; Víctor, Víctor M.; Barrachina Sancho, María Dolores; Blas García, Ana; Esplugues Mota, Juan V. Elsevier (2013-10)
      Background & Aims ER stress is associated with a growing number of liver diseases, including drug-induced hepatotoxicity. The non-nucleoside analogue reverse transcriptase inhibitor Efavirenz, a cornerstone of the ...

    • closedAccess   Heat Stress Induces Extended Plateau of Hsp70 Accumulation – A Possible Cytoprotection Mechanism in Hepatic Cells 

      Miova, Biljana; Dinevska-Kjovkarovska, Suzana; Esplugues Mota, Juan V.; Apostolova, Nadezda Wiley (2015-08-15)
      The relevance of heat preconditioning resides in its ability to protect cells from different kinds of injury by induction of heat shock proteins, a process in which the intensity of heat stress (HS) and duration of subsequent ...

    • openAccess   Involvement of nitric oxide in the mitochondrial action of efavirenz: a differential effect on neurons and glial cells 

      Apostolova, Nadezda; Funes, Haryes A.; Blas García, Ana; Alegre, Fernando; Polo, Míriam; Esplugues Mota, Juan V. Oxford University Press (2014-12)
      The anti-human immunodeficiency virus (HIV) drug efavirenz (EFV) alters mitochondrial function in cultured neurons and glial cells. Nitric oxide (NO) is a mediator of mitochondrial dysfunction associated with HIV central ...

    • closedAccess   Is Glycemic Control Modulating Endoplasmic Reticulum Stress in Leukocytes of Type 2 Diabetic Patients? 

      Rovira Llopis, Susana; Bañuls, Celia; Apostolova, Nadezda; Morillas, Carlos; Hernández Mijares, Antonio; Rocha, Milagros; Víctor, Víctor M. Mary Ann Liebert Inc. (2014-10-06)
      Oxidative and endoplasmic reticulum (ER) stress is related to type 2 diabetes (T2D), but the influence of glycemic control on these parameters and its relationship with leukocyte-endothelial interactions is not known. In ...

    • closedAccess   Mitochondrial (dys)function-a factor underlying the variability of EFV-induced hepatoxicity? 

      Polo, Míriam; Alegre, Fernando; Funes, Haryes A.; Blas García, Ana; Víctor, Víctor M.; Esplugues Mota, Juan V.; Apostolova, Nadezda Wiley (2015-01-08)
      Background and PurposeThe non-nucleoside analogue reverse transcriptase inhibitor efavirenz is associated with hepatic toxicity and metabolic disturbances. Although the mechanisms involved are not clear, recent evidence ...

    • closedAccess   Molecular Strategies for Targeting Antioxidants to Mitochondria: Therapeutic Implications 

      Apostolova, Nadezda; Víctor, Víctor M. Mary Ann Liebert (2015-03-10)
      Mitochondrial function and specifically its implication in cellular redox/oxidative balance is fundamental in controlling the life and death of cells, and has been implicated in a wide range of human pathologies. In this ...

    • openAccess   Neuronal Bioenergetics and Acute Mitochondrial Dysfunction: A Clue to Understanding the Central Nervous System Side Effects of Efavirenz 

      Funes, Haryes A.; Apostolova, Nadezda; Alegre, Fernando; Blas García, Ana; Álvarez, Ángeles; Martí Cabrera, Miguel; Esplugues Mota, Juan V. Oxford University Press (2014-05)
      Background. Neurological pathogenesis is associated with mitochondrial dysfunction and differences in neuronal/glial handling of oxygen and glucose. The main side effects attributed to efavirenz involve the CNS, but the ...

    • openAccess   Perspectives and Potential Applications of Mitochondria-Targeted Antioxidants in Cardiometabolic Diseases and Type 2 Diabetes 

      Rocha, Milagros; Apostolova, Nadezda; Herance, Jose Raul; Rovira Llopis, Susana; Hernández Mijares, Antonio; Víctor, Víctor M. John Wiley & Sons (2013)
      There is abundant evidence to suggest that mitochondrial dysfunction is a main cause of insulin resistance and related cardiometabolic comorbidities. On the other hand, insulin resistance is one of the main characteristics ...

    • closedAccess   The purine analogues abacavir and didanosine increase acetaminophen-induced hepatotoxicity by enhancing mitochondrial dysfunction 

      Blas García, Ana; Martí Rodrigo, Alberto; Víctor, Víctor M.; Polo, Míriam; Alegre, Fernando; Funes, Haryes A.; Apostolova, Nadezda; Esplugues Mota, Juan V. Oxford University Press (2016-01-07)
      Background NRTIs are essential components of HIV therapy with well-documented, long-term mitochondrial toxicity in hepatic cells, but whose acute effects on mitochondria are unclear. As acetaminophen-induced hepatotoxicity ...

    • closedAccess   Using exomarkers to assess mitochondrial reactive species in vivo 

      Logan, Angela; Cochemé, Helena M.; Boon Li Pun, Pamela; Apostolova, Nadezda; Smith, Robin A. J.; Larsen, Lesley; Larsen, David S.; James, Andrew M.; Fearnley, Ian M.; Rogatti, Sebastian; Prime, Tracy A.; Finichiu, Peter G.; Dare, Anna; Chouchani, Edward T.; Pell, Victoria R.; Methner, Carmen; Quin, Caroline; McQuaker, Stephen J.; Krieg, Thomas; Hartley, Richard C.; Murphy, Michael P. Elsevier (2014-02)
      Background The ability to measure the concentrations of small damaging and signalling molecules such as reactive oxygen species (ROS) in vivo is essential to understanding their biological roles. While a range of methods ...