Listar MED_Articles por autoría "3ad5a218-e3b0-4794-a8a7-ff7ad82762dd"
Mostrando ítems 1-17 de 17
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Central relaxin-3 receptor (RXFP3) activation impairs social recognition and modulates ERK-phosphorylation in specific GABAergic amygdala neurons
Albert Gasco, Hector; Sánchez-Sarasúa, Sandra; Ma, Sherie; García Díaz, Cristina; Gundlach, Andrew Lawrence; Sánchez-Pérez, Ana María; Olucha-Bordonau, Francisco E Springer (2019-01)In mammals, the extended amygdala is a neural hub for social and emotional information processing. In the rat, the extended amygdala receives inhibitory GABAergic projections from the nucleus incertus (NI) in the pontine ... -
Central relaxin-3 receptor (RXFP3) activation increases ERK phosphorylation in septal cholinergic neurons and impairs spatial working memory.
Albert Gasco, Hector; García Avilés, Álvaro; Moustafa, S.; Sánchez-Sarasúa, Sandra; Gundlach, Andrew Lawrence; Olucha-Bordonau, Francisco E; Sánchez-Pérez, Ana María Springer (2016-05-05)The medial septum/diagonal band (MS/DB) is a relay region connecting the hypothalamus and brainstem with the hippocampus, and both the MS/DB and dorsal/ventral hippocampus receive strong topographic GABA/peptidergic ... -
Comparative Distribution of Relaxin-3 Inputs and Calcium-Binding Protein-Positive Neurons in Rat Amygdala
Santos, F. N.; Pereira, C. W.; Sánchez-Pérez, Ana María; Otero García, Marcos; Ma, Sherie; Gundlach, Andrew Lawrence; Olucha-Bordonau, Francisco E Frontiers Media (2016)The neural circuits involved in mediating complex behaviors are being rapidly elucidated using various newly developed and powerful anatomical and molecular techniques, providing insights into the neural basis for anxiety ... -
Distribution and targets of the relaxin-3 innervation of the septal area in the rat
Sánchez-Pérez, Ana María; Olucha-Bordonau, Francisco E; Otero García, Marcos; Núñez, Ángel; Ma, Sherie; Gundlach, Andrew Lawrence Wiley-Blackwell (2012)Neural tracing studies have revealed that the rat medial and lateral septum are targeted by ascending projections from the nucleus incertus, a population of tegmental GABA neurons. These neurons express the relaxin-family ... -
Electrolytic lesion of the nucleus incertus retards extinction of auditory conditioned fear
Pereira, C. W.; Santos, F. N.; Sánchez-Pérez, Ana María; Otero García, Marcos; Marchioro, M.; Ma, Sherie; Gundlach, Andrew Lawrence; Olucha-Bordonau, Francisco E Elsevier (2013-06-15)Fear memory circuits in the brain function to allow animals and humans to recognize putative sources of danger and adopt an appropriate behavioral response; and research on animal models of fear have helped reveal the ... -
GABAergic Neurons in the Rat Medial Septal Complex Express Relaxin-3 Receptor (RXFP3) mRNA
Albert Gasco, Hector; Ma, Sherie; Ros Bernal, Francisco; Sánchez-Pérez, Ana María; Gundlach, Andrew Lawrence; Olucha-Bordonau, Francisco E Frontiers Media (2018-01-17)The medial septum (MS) complex modulates hippocampal function and related behaviors. Septohippocampal projections promote and control different forms of hippocampal synchronization. Specifically, GABAergic and cholinergic ... -
Involvement of the Nucleus Incertus and Relaxin-3/RXFP3 Signaling System in Explicit and Implicit Memory
Gil-Miravet, Isis; Mañas-Ojeda, Aroa; Ros Bernal, Francisco; Castillo-Gómez, Esther; Albert Gasco, Hector; Gundlach, Andrew Lawrence; Olucha-Bordonau, Francisco E Frontiers Media (2021-03-18)Telencephalic cognitive and emotional circuits/functions are strongly modulated by subcortical inputs. The main focus of past research on the nature of this modulation has been on the widespread monoamine projections to ... -
Modulation of contextual fear acquisition and extinction by acute and chronic relaxin-3 receptor (RXFP3) activation in the rat retrosplenial cortex
Navarro Sánchez, Mónica; Gil-Miravet, Isis; Montero Caballero, Daniel; Bathgate, Ross A. D.; Hossain, Mohammed Akhter; Castillo-Gómez, Esther; Gundlach, Andrew Lawrence; Olucha-Bordonau, Francisco E Elsevier (2024-07)The retrosplenial cortex (RSC) plays a central role in processing contextual fear conditioning. In addition to corticocortical and thalamocortical projections, the RSC receives subcortical inputs, including a substantial ... -
Modulation of forebrain function by nucleus incertus and relaxin-3/RXFP3 signaling
Olucha-Bordonau, Francisco E; Albert Gasco, Hector; Ros Bernal, Francisco; Rytova, Valeria; Ong-Pålsson, Emma K. E.; Ma, Shuai; Sánchez-Pérez, Ana María; Gundlach, Andrew Lawrence Wiley (2018)The nucleus incertus (NI) in the pontine tegmentum sends ascending projections to the midbrain, hypothalamus, amygdala, basal forebrain, hippocampus, and prefrontal cortex, and has a postulated role in modulating several ... -
Noncovalent Peptide Stapling Using Alpha-Methyl-l-Phenylalanine for α-Helical Peptidomimetics
Bathgate, Ross A. D.; Praveen, Praveen; Sethi, Ashish; Dhingra, Rishi R.; Kocan, Martina; Ou, Qinghao; Valkovic, Adam L.,; Gil-Miravet, Isis; Navarro Sánchez, Mónica; Olucha-Bordonau, Francisco E; Gundlach, Andrew Lawrence; Rosengren, K. Johan; Dutschmann, Mathias; Hossain, Mohammed Akhter American Chemical Society (2023-08-20)Peptides and peptidomimetics are attractive drug candidates because of their high target specificity and low-toxicity profiles. Developing peptidomimetics using hydrocarbon (HC)-stapling or other stapling strategies has ... -
Nucleus incertus ablation disrupted conspecific recognition and modified immediate early gene expression patterns in ‘social brain’ circuits of rats
García Díaz, Cristina; Sánchez-Catalán, María José; Castro-Salazar, E.; García Avilés, Álvaro; Albert Gasco, Hector; Sánchez-Sarasúa, Sandra; Sánchez-Pérez, Ana María; Gundlach, Andrew Lawrence; Olucha-Bordonau, Francisco E Elsevier (2019-01-01)Social interaction involves neural activity in prefrontal cortex, septum, hippocampus, amygdala and hypothalamus. Notably, these areas all receive projections from the nucleus incertus (NI) in the pontine tegmentum. ... -
Nucleus incertus projections to rat medial septum and entorhinal cortex: rare collateralization and septal-gating of temporal lobe theta rhythm activity
Gil-Miravet, Isis; Nuñez Molina, Angel; Navarro Sánchez, Mónica; Castillo-Gómez, Esther; Ros, Francisco; Gundlach, Andrew Lawrence; Olucha-Bordonau, Francisco E Springer (2023)Nucleus incertus (NI) neurons in the pontine tegmentum give rise to ascending forebrain projections and express the neuropeptide relaxin-3 (RLN3) which acts via the relaxin-family peptide 3 receptor (RXFP3). Activity in ... -
Postnatal development of the relaxin-3 innervation of the rat medial septum
ROS, FRANCISCO; Gil-Miravet, Isis; Lucerón Morales, Jorge; Navarro Sánchez, Mónica; Castillo-Gómez, Esther; Gundlach, Andrew Lawrence; Olucha-Bordonau, Francisco E Frontiers Media (2023)Introduction: The septal area provides a rich innervation to the hippocampus regulating hippocampal excitability to different behavioral states and modulating theta rhythmogenesis. However, little is known about the ... -
Relaxin ligand/receptor systems in the developing teleost fish brain: Conserved features with mammals and a platform to address neuropeptide system functions
Blasiak, Anna; Guguła, Anna; Gundlach, Andrew Lawrence; Olucha-Bordonau, Francisco E; ANIELLO, Francesco; DONIZETTI, Aldo Frontiers Media (2022)The relaxins (RLNs) are a group of peptide hormone/neuromodulators that can regulate a wide range of physiological processes ranging from reproduction to brain function. All the family members have originated from a RLN3-like ... -
Relaxin-3 Innervation From the Nucleus Incertus to the Parahippocampal Cortex of the Rat
García Díaz, Cristina; Gil-Miravet, Isis; Albert Gasco, Hector; Mañas-Ojeda, Aroa; Ros Bernal, Francisco; Castillo-Gómez, Esther; Gundlach, Andrew Lawrence; Olucha-Bordonau, Francisco E Frontiers Media (2021)Spatial learning and memory processes depend on anatomical and functional interactions between the hippocampus and the entorhinal cortex. A key neurophysiological component of these processes is hippocampal theta rhythm, ... -
Septal projections to the nucleus incertus in the rat: Bidirectional pathways for modulation of hippocampal function
Sánchez-Pérez, Ana María; Arnal Vicente, Isabel; Santos, F. N.; Pereira, C. W.; El Mlili, Nisrin; Sanjuán, Julio; Ma, Sherie; Gundlach, Andrew Lawrence; Olucha-Bordonau, Francisco E Wiley (2015-03)Projections from the nucleus incertus (NI) to the septum have been implicated in the modulation of hippocampal theta rhythm. In this study we describe a previously uncharacterized projection from the septum to the NI, which ... -
Some key parameters in contextual fear conditioning and extinction in adult rats
Navarro Sánchez, Mónica; Gil-Miravet, Isis; Montero Caballero, Daniel; Castillo-Gómez, Esther; Gundlach, Andrew Lawrence; Olucha-Bordonau, Francisco E Elsevier (2024-03-28)Contextual fear conditioning is a behavioral paradigm used to assess hippocampal-dependent memory in experimental animals. Perception of the context depends on activation of a distinct population of neurons in the hippocampus ...