• openAccess   Dilute-and-shoot approach for the high-throughput LC-MS/MS determination of illicit drugs in the field of wastewater-based epidemiology 

      Gracia-Marín, Elisa; Hernández, Félix; Ibañez Martinez, Maria; Bijlsma, Lubertus Elsevier (2024-06-08)
      The determination of illicit drugs in urban influent wastewater (IWW) enables the monitoring of spatial and temporal drug usage trends and assessment of community lifestyle habits. The increasing number of wastewater ...
    • closedAccess   Influent wastewater analysis to investigate emerging trends of new psychoactive substances use in Europe 

      Salgueiro-González, Noelia; Been, Frederic; Bijlsma, Lubertus; Boogaerts, Tim; Covaci, Adrian; Baz Lomba, Jose Antonio; Kasprzyk-Hordern, Barbara; Matias, João; Ort, Christoph; Bodík, Igor; Heath, Ester; Styszko, Katarzyna; Emke, Erik; Hernandez, Felix; van Nuijs, Alexander; Castiglioni, Sara Elsevier (2024-01-27)
      Wastewater-based epidemiology (WBE) can provide objective and timely information on the use of new psychoactive substances (NPS), originally designed as legal alternatives of internationally controlled drugs. NPS have ...
    • openAccess   Necroptosis induced by ruthenium (II) complexes as mitochondrial disruptors 

      Gonçalves, Joana; Amaral, Joana; Capela, Rita; Perry, Maria Jesus; Braga, Cláudia; Gaspar, Maria Manuela; Piedade, M. Fatima; Bijlsma, Lubertus; Roig-Navarro, Antoni F.; Pinto, Sandra N.; Moreira, Rui; Florindo, Pedro; Rodrigues, Cecília M. P. Springer Nature (2024-05-28)
      Inducing necroptosis in cancer cells has emerged as an effective strategy to overcome drug resistance. However, while organic small molecules have been extensively studied for this purpose, metal-based compounds have ...
    • openAccess   NORMAN guidance on suspect and non-target screening in environmental monitoring 

      Hollender, Juliane; Schymanski, Emma; Ahrens, Lutz; Alygizakis, Nikiforos; Been, Frederic; Bijlsma, Lubertus; Brunner, Andrea Mizzi; Celma, Alberto; FILDIER, aurelie; FU, QIUGUO; Gago-Ferrero, Pablo; Gil Solsona, Ruben; Haglund, Peter; Hansen, Martin; Kaserzon, Sarit; Kruve-Viil, Anneli; Lamoree, Marja; MARGOUM, Christelle; Meijer, Jeroen; Merel, Sylvain; Rauert, Cassandra; Rostkowski, Pawel; Samanipour, Saer; Schulze, Bastian; Schulze, Tobias; Singh, Randolph; Slobodnik, Jaroslav; Steininger-Mairinger, Teresa; Thomaidis, Nikolaos; Togola, Anne; Vorkamp, Katrin; VULLIET, Emmanuelle; Zhu, Linyan; Krauss, Martin Springer (2023-09-04)
      Increasing production and use of chemicals and awareness of their impact on ecosystems and humans has led to large interest for broadening the knowledge on the chemical status of the environment and human health by suspect ...
    • openAccess   Peripheral modulation of antidepressant targets MAO-B and GABAAR by harmol induces mitohormesis and delays aging in preclinical models 

      Costa-Machado, Luis Filipe; García-Domínguez, Esther; McIntyre, Rebecca L.; Lopez Aceituno, Jose Luis; Ballesteros-González, Álvaro; Tapia-Gonzalez, Andrea; Fabregat-Safont, David; Eisenberg, Tobias; Gómez, Jesús; Plaza, Adrian; Sierra Ramírez, Arantzazu; Pérez, Manuel; Villanueva Bermejo, David; Fornari, Tiziana; Loza García, María Isabel; Herradón, Gonzalo; Hofer, Sebastian; Magnes, Christoph; Madeo, Frank; Duerr, Janet S.; Pozo, Oscar; Galindo, Máximo Ibo; del Pino, Isabel; Houtkooper, Riekelt H.; Megias, Diego; Viña, José; Gomez-Cabrera , Mari Carmen; Fernandez-Marcos, Pablo J. Nature Research (2023)
      Reversible and sub-lethal stresses to the mitochondria elicit a program of compensatory responses that ultimately improve mitochondrial function, a conserved anti-aging mechanism termed mitohormesis. Here, we show ...
    • openAccess   Workflow to facilitate the detection of new psychoactive substances and drugs of abuse in influent urban wastewater 

      Bade, Richard; van Herwerden, Denice; Rousis, Nikolaos I; Adhikari, Sangeet; Allen, Darren; Baduel, Christine; Bijlsma, Lubertus; Boogaerts, Tim; Burgard, Dan; Chappell, Andrew; Driver, Erin M.; Fabriz Sodré, Fernando; Fatta-Kassinos, Despo; GRACIA LOR, EMMA; Gracia-Marín, Elisa; Halden, Rolf; Heath, Ester; Keller, Emma; Krotulski, Alex; Lai, Foon Yin; Mueller, Jochen Elsevier (2024-03-08)
      The complexity around the dynamic markets for new psychoactive substances (NPS) forces researchers to develop and apply innovative analytical strategies to detect and identify them in influent urban wastewater. In this ...