• openAccess   Metabolism of N-ethylhexedrone and buphedrone: An in vivo study in mice using HPLC-MS/MS 

      Carrola, Diana; Duarte, Noélia; Florindo, Pedro; Henriques, Sara Carolina; Bijlsma, Lubertus; Moreira, Rui; Ribeiro Correia, Catarina; Perry, Maria Jesus; Lopes, Alvaro; de Mello Sampayo, Cristina; Bronze, Maria do Rosário Elsevier (2020-08-25)
      N-ethylhexedrone (NEH) and buphedrone (BUPH) are synthetic drugs structurally related to natural cathinone. These synthetic cathinones (SC) are members of the heterogenous family of new psychoactive substances (NPS), which ...
    • openAccess   Necroptosis induced by ruthenium (II) complexes as mitochondrial disruptors 

      Gonçalves, Joana; Amaral, Joana; Capela, Rita; Perry, Maria Jesus; Braga, Cláudia; Gaspar, Maria Manuela; Piedade, M. Fatima; Bijlsma, Lubertus; Roig-Navarro, Antoni F.; Pinto, Sandra N.; Moreira, Rui; Florindo, Pedro; Rodrigues, Cecília M. P. Springer Nature (2024-05-28)
      Inducing necroptosis in cancer cells has emerged as an effective strategy to overcome drug resistance. However, while organic small molecules have been extensively studied for this purpose, metal-based compounds have ...