Visualitza IUPA_Articles per autoria "1291cb7e-d165-4e5d-9f39-1948e8849e25"
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In-depth comparison of the metabolic and pharmacokinetic behaviour of the structurally related synthetic cannabinoids AMB-FUBINACA and AMB-CHMICA in rats
Fabregat-Safont, David; Mata-Pesquera, Maria; Barneo-Muñoz, Manuela; Martinez-Garcia, Fernando; Mardal, Marie; Davidsen, Anders Bork; Sancho, Juan V; Hernandez, Felix; Ibañez Martinez, Maria Springer Nature (2022-02-24)Synthetic cannabinoids receptor agonists (SCRAs) are often almost completely metabolised, and hence their pharmacokinetics should be carefully evaluated for determining the most adequate biomarker in toxicological analysis. ... -
Novel sampling strategy for alive animal volatolome extraction combined with GC-MS based untargeted metabolomics: Identifying mouse pup pheromones
Lacalle-Bergeron, Leticia; Goterris-Cerisuelo, Rafael; Portoles, Tania; Beltran Arandes, Joaquin; Sancho, Juan V; Navarro-Moreno, Cinta; Martinez-Garcia, Fernando Elsevier (2021-08-04)In this study, we identify 11 mouse pup volatiles putatively involved in maternal care induction in adult females. For this purpose, we have adapted the dynamic headspace methodology to extract the volatolome of whole alive ... -
Proposal of 5-methoxy-N-methyl-N-isopropyltryptamine consumption biomarkers through identification of in vivo metabolites from mice
Fabregat-Safont, David; Barneo-Muñoz, Manuela; Martinez-Garcia, Fernando; Sancho, Juan V; Hernandez, Felix; Ibáñez, Maria Elsevier (2017-07)New psychoactive substances (NPS) are a new breed of synthetically produced substances designed to mimic the effects of traditional illegal drugs. Synthetic cannabinoids and synthetic cathinones are the two most common ... -
Understanding the pharmacokinetics of synthetic cathinones: Evaluation of the blood–brain barrier permeability of 13 related compounds in rats
Fabregat-Safont, David; Barneo-Muñoz, Manuela; Carbón, Xoán; Hernandez, Felix; Martinez-Garcia, Fernando; Ventura, Mireia; Stove, Christophe P.; Sancho, Juan V; Ibáñez, Maria Wiley (2020)Synthetic cathinones are the second most commonly seized new psychoactive substance family in Europe. These compounds have been related to several intoxication cases, including fatalities. Although the pharmacological ... -
Untargeted metabolomics approach using UHPLC-IMS-QTOF MS for surface body samples to identify low-volatility chemosignals related to maternal care in mice
Lacalle-Bergeron, Leticia; Goterris-Cerisuelo, Rafael; Beltran Arandes, Joaquin; Sancho Llopis, Juan Vicente; Navarro-Moreno, Cinta; Martinez-Garcia, Fernando; Portoles, Tania Elsevier (2023)The present study is focused on the determination of low-volatile chemosignals excreted or secreted by mouse pups in their early days of life involved in maternal care induction in mice adult females. Untargeted metabolomics ...