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Big dynorphin is a neuroprotector scaffold against amyloid β-peptide aggregation and cell toxicity
(Elsevier, 2022)
Amyloid β-peptide (Aβ) misfolding into β-sheet structures triggers neurotoxicity inducing Alzheimer’s disease (AD). Molecules able to reduce or to impair Aβ aggregation are highly relevant as possible AD treatments since ...
The P. aeruginosa effector Tse5 forms membrane pores disrupting the membrane potential of intoxicated bacteria
(Nature Research, 2022)
The type VI secretion system (T6SS) of Pseudomonas aeruginosa injects effector proteins into neighbouring competitors and host cells, providing a fitness advantage that allows this opportunistic nosocomial pathogen to ...
Structural and functional insights into the delivery of a bacterial Rhs pore-forming toxin to the membrane
(Nature Research, 2023-11-28)
Bacterial competition is a significant driver of toxin polymorphism, which allows continual compensatory evolution between toxins and the resistance developed to overcome their activity. Bacterial Rearrangement hot spot ...
Effect of metallacarborane salt H[COSANE] doping on the performance properties of polybenzimidazole membranes for high temperature PEMFCs
(Royal Society of Chemistry, 2020-07-31)
In this paper, a series of composite proton exchange membranes comprising a cobaltacarborane
protonated H[Co(C2B9H11)2] named (H[COSANE]) and polybenzimidazole (PBI) for a high temperature
proton exchange membrane fuel ...
Biphasic concentration patterns in ionic transport under nanoconfinement revealed in steady-state and time-dependent properties
(American Institute of Physics, 2023-02-08)
Ion permeation across nanoscopic structures differs considerably from microfluidics because of strong steric constraints, transformed solvent properties, and charge-regulation effects revealed mostly in diluted solutions. ...
The Cytoplasmic Domain of the SARS-CoV-2 Envelope Protein Assembles into a β-Sheet Bundle in Lipid Bilayers
(Elsevier, 2023-01-28)
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) envelope (E) protein forms a pentameric ion channel in the lipid membrane of the endoplasmic reticulum Golgi intermediate compartment (ERGIC) of the infected ...
Charged Biological Membranes Repel Large Neutral Molecules by Surface Dielectrophoresis and Counterion Pressure
(American Chemical Society, 2024-01-16)
Macromolecular crowding is the usual condition of cells. The implications of the crowded cellular environment for protein stability and folding, protein-protein interactions, and intracellular transport drive a growing ...
African Swine Fever Virus Gene B117L Encodes a Small Protein Endowed with Low-pH-Dependent Membrane Permeabilizing Activity
(American Society for Microbiology, 2023-05-22)
African swine fever virus (ASFV) is causing a devastating pandemic in domestic and wild swine in Central Europe to East Asia, resulting in economic losses for the swine industry. The virus contains a large double-stranded ...
Water oxidation kinetics of nanoporous BiVO4 photoanodes functionalised with nickel/iron oxyhydroxide electrocatalysts
(Royal Society of Chemistry, 2021-04-15)
In this work, spectroelectrochemical techniques are employed to analyse the catalytic water oxidation performance of a series of three nickel/iron oxyhydroxide electrocatalysts deposited on FTO and BiVO4, at neutral pH. ...
Green nanoparticle synthesis at scale : a perspective on overcoming the limits of pulsed laser ablation in liquids for high-throughput production
(Royal Society of Chemistry, 2023-07-06)
Nanoparticles have become increasingly important for a variety of applications, including medical diagnosis and treatment, energy harvesting and storage, catalysis, and additive manufacturing. The development of nanoparticles ...