Browsing Departament: Física by Author "49b31ad6-fc01-4370-8669-22298a9948e9"
Now showing items 1-6 of 6
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Channel-Inactivating Mutations and Their Revertant Mutants in the Envelope Protein of Infectious Bronchitis Virus
To, Janet; Surya, Wahyu; To, Sing Fung; Li, Yan; Verdiá Báguena, Carmen; Queralt-Martín, María; Aguilella, Vicente; Ding, Xiang Liu; Torres, Jaume American Society for Microbiology (2016-12)It has been shown previously in the severe acute respiratory syndrome coronavirus (SARS-CoV) that two point mutations, N15A and V25F, in the transmembrane domain (TMD) of the envelope (E) protein abolished channel activity ... -
Inhibition of the human respiratory syncytial virus small hydrophobic protein and structural variations in a bicelle environment
Li, Yan; To, Janet; Verdiá Báguena, Carmen; Dossena, Silvia; Surya, Wahyu; Huang, Mei; Paulmichl, Markus; Liu, Ding Xiang; Aguilella, Vicente; Torres, Jaume American Society for Microbiology (2014)The small hydrophobic (SH) protein is a 64-amino-acid polypeptide encoded by the human respiratory syncytial virus (hRSV). SH protein has a single α-helical transmembrane (TM) domain that forms pentameric ion channels. ... -
MERS coronavirus envelope protein has a single transmembrane domain that forms pentameric ion channels
Surya, Wahyu; Li, Yan; Verdiá Báguena, Carmen; Aguilella, Vicente; Torres, Jaume Elsevier (2015-04)The Middle East respiratory syndrome coronavirus (MERS-CoV) is a newly identified pathogen able of human transmission that causes a mortality of almost 40%. As in the case of SARS-CoV, MERS virus lacking E protein represents ... -
SARS-CoV-2 accessory protein 7b forms homotetramers in detergent
Surya, Wahyu; Queralt-Martin, Raquel; Mu, Yuguang; Aguilella, Vicente; Torres, Jaume BioMed Central (BMC) (2022-11)A global pandemic is underway caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The SARS-CoV-2 genome, like its predecessor SARS-CoV, contains open reading frames that encode accessory proteins ... -
The Complex Proteolipidic Behavior of the SARS-CoV-2 Envelope Protein Channel: Weak Selectivity and Heterogeneous Oligomerization
Surya, Wahyu; Tavares Neto, Ernesto; Sanchis, Andrea; Queralt-Martín, María; Alcaraz, Antonio; Torres, Jaume; Aguilella, Vicente Multidisciplinary Digital Publishing Institute (MDPI) (2023-08-05)The envelope (E) protein is a small polypeptide that can form ion channels in coronaviruses. In SARS coronavirus 2 (SARS-CoV-2), the agent that caused the recent COVID-19 pandemic, and its predecessor SARS-CoV-1, E protein ... -
The Cytoplasmic Domain of the SARS-CoV-2 Envelope Protein Assembles into a β-Sheet Bundle in Lipid Bilayers
Dregni, Aurelio J.; McKay, Matthew; Surya, Wahyu; Queralt-Martin, Maria; Medeiros-Silva, João; Wang, Harrison K.; Aguilella, Vicente; Torres, Jaume; Hong, Mei Elsevier (2023-01-28)The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) envelope (E) protein forms a pentameric ion channel in the lipid membrane of the endoplasmic reticulum Golgi intermediate compartment (ERGIC) of the infected ...