Visualitza Departament: Física per autoria "1d128e3c-d1fe-420d-ac95-28146fb508ea"
Ara mostrant els elements 1-3 d 3
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Ion channel activity of the CSFV p7 viroporin in surrogates of the ER lipid bilayer
Largo, Eneko; Verdiá Báguena, Carmen; Aguilella, Vicente; Nieva, José L.; Alcaraz, Antonio Elsevier (2016-01)Viroporins comprise a family of non-structural proteins that play significant and diverse roles during the replication cycle of many animal viruses. Consequently, they have become promising targets for inhibitory drug and ... -
Mutation-induced changes of transmembrane pore size revealed by combined ion-channel conductance and single vesicle permeabilization analyses
Largo, Eneko; Gladue, Douglas; Torralba, Johana; Aguilella, Vicente; Alcaraz, Antonio; Borca, Manuel V.; Nieva, José L. Elsevier (2018-05)Permeabilization of the Endoplasmic Reticulum (ER) is instrumental in the progression of host-cell infection by many viral pathogens. We have described that permeabilization of ER model membranes by the pore-forming domain ... -
Single-molecule conformational dynamics of viroporin ion channels regulated by lipid-protein interactions
Largo, Eneko; Queralt-Martín, María; Carravilla Palomanes, Pablo; Nieva, José L.; Alcaraz, Antonio Elsevier (2020-02)Classic swine fever is a highly contagious and often fatal viral disease that is caused by the classical swine fever virus (CSFV). Protein p7 of CFSV is a prototype of viroporin, a family of small, highly hydrophobic ...