Impact of brief maternal separation on rodent models of anergia induced by dopamine depletion: analysis in mice of both sexes during adulthood
Ver/ Abrir
Impacto
Scholar |
Otros documentos de la autoría: Matas-Navarro, Paula; Carratalá-Ros, Carla; Martínez-Verdú, Andrea; Salamone, John; Correa, Merce
Metadatos
Mostrar el registro completo del ítemcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/8033
comunitat-uji-handle3:10234/186929
comunitat-uji-handle4:
INVESTIGACIONMetadatos
Título
Impact of brief maternal separation on rodent models of anergia induced by dopamine depletion: analysis in mice of both sexes during adulthoodAutoría
Fecha de publicación
2024Tipo de documento
DatasetVersión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
Mesolimbic dopamine (DA) regulates activation and effort in motivated behaviors.
Impairments in DA function induce motivational symptoms such as anergia and fatigue
seen in depression. Stress modulates DA depending ... [+]
Mesolimbic dopamine (DA) regulates activation and effort in motivated behaviors.
Impairments in DA function induce motivational symptoms such as anergia and fatigue
seen in depression. Stress modulates DA depending on its duration and intensity.
Early-life events such as maternal separation (MS) could act as a stressor, affecting
brain development and leading to behavioral changes later in life. However, little is
known about the effect of early-life stressors on adult effort-based decision-making.
CD1 male and female mice were subjected to early-mild MS (PND3-5, 90 min/day),
and, during adulthood, were evaluated on selection of effortful responses under
positive or aversive experimental conditions. The choice to engage in effortful activities
such as running in a wheel (RW) versus engaging with passive reinforcers was
evaluated in a three-choice-T-maze task. In the forced swim task (FST), time dedicated
to vigorously escaping versus passively floating was measured. MS mice of both
sexes, spent more time in the RW, and climbing in the FST, showing an increase in
relative preferences for activity-based reinforcers, and persistence in vigorous escaping
from aversive contexts compared to non-separated mice. Separated animals were less
anxious but males were less socially oriented. DA depletion induced anergia in males,
and increased the neurotrophic factor CDNF in Nacb of both sexes independently of
separation conditions. Measures of anxiety, social interaction and sucrose preference
and consumption were not affected after DA depletion. Thus, mild-early MS potentiates
effortful behaviors during adulthood independently of the emotional value of the
situation. Males were more vulnerable to DA-depletion induced-anergia. [-]
Entidad financiadora
Universitat Jaume I | Ministerio de Ciencia e Innovación
Código del proyecto o subvención
UJI-B2018-31 | PID2021-125977OB-I00
Derechos de acceso
info:eu-repo/semantics/openAccess