Folic Acid Supplementation during Pregnancy and Its Association with Telomere Length in Children at Four Years: Results from the INMA Birth Cohort Study
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Other documents of the author: Petermann Rocha, Fanny; Valera-Gran, Desirée; Prieto Botella, Daniel; Martens, Dries S; González Palacios, Sandra; Riaño-Galan, Isolina; Murcia, Mario; Irizar Loibide, Amaia; Julvez, Jordi; Santa-Marina, Loreto; Tardón, Adonina; Sunyer, Jordi; Vioque, Jesus; Nawrot, Tim; Navarrete-Muñoz, Eva María
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comunitat-uji-handle2:10234/36080
comunitat-uji-handle3:10234/36082
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INVESTIGACIONMetadata
Title
Folic Acid Supplementation during Pregnancy and Its Association with Telomere Length in Children at Four Years: Results from the INMA Birth Cohort StudyAuthor (s)
Date
2023Publisher
MDPIBibliographic citation
Petermann-Rocha, F.; Valera-Gran, D.; Prieto-Botella, D.; Martens, D.S.; Gonzalez-Palacios, S.; Riaño-Galán, I.; Murcia, M.; Irizar, A.; Julvez, J.; Santa-Marina, L.; et al. Folic Acid Supplementation during Pregnancy and Its Association with Telomere Length in Children at Four Years: Results from the INMA Birth Cohort Study. Nutrients 2023, 15, 4303. https://doi.org/10.3390/ nu15194303Type
info:eu-repo/semantics/articlePublisher version
https://www.mdpi.com/2072-6643/15/19/4303Version
info:eu-repo/semantics/publishedVersionSubject
Abstract
This study examined the association between folic acid supplements (FAs) during different
periods of pregnancy and offspring telomere length (TL) at age four in 666 children from the INMA
study. FAs were self-reported ... [+]
This study examined the association between folic acid supplements (FAs) during different
periods of pregnancy and offspring telomere length (TL) at age four in 666 children from the INMA
study. FAs were self-reported using food-structured questionnaires during three periods of pregnancy
(the first three months of pregnancy, from month fourth onward, and the whole pregnancy). For each
period, the average daily dosage of FAs was categorised into (i) <400 µg/d, (ii) ≥400 to 999 µg/d,
(iii) ≥1000 to 4999 µg/d, and (iv) ≥5000 µg/d. Leucocyte TL at age four was measured using
quantitative PCR methods. Multiple robust linear log-level regression models were used to report
the % difference among FA categories. During the first period, and compared with children whose
mothers were classified in the reference group (<400 µg/d), children whose mothers took higher dosages of FAs showed shorter TL at age four (≥5000 µg/d). When the first and the second periods
were mutually adjusted, children whose mothers self-reported ≥5000 µg/d during the first period
of pregnancy had a statistically significant shorter TL than their counterparts (% difference: −7.28%
[95% CI: −14.42 to −0.13]). Similar trends were observed for the whole period of pregnancy. When
the analysis was stratified by sex, the association was more evident in boys (% difference: −13.5%
[95% CI: −23.0 to −4.04]), whereas no association was observed in girls. This study suggests that
high dosages of FAs in the first pregnancy period may be associated with a shorter TL in children at
age four, particularly among boys. Further studies should confirm these results. [-]
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Nutrients 2023, 15(19), 4303.Funder Name
Unión Europea (FEDER) | Generalitat Valenciana | Instituto de Salud Carlos III/Agencia Estatal de Investigación | Generalitat de Catalunya-CIRIT | Provincial Government of Gipuzkoa | State Research Agency | European Commission | Federación Española de Enfermedades Raras | Ministerio de Economía y Competitividad | Ministerio de Ciencia e Innovación | Universidad de Oviedo | Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail
Project code
PI18/00825 | PI07/0314 | PI11/01007 | GVA/2021/191 | 1999SGR 00241 | CPII19/00015 | DFG06/002 | DFG08/001 | CEX2018-000806-S | 261357 | 308333 | 603794 | 634453 | SAF2012 | CB06/02/0041 | CP13/00054 | CPII18/00018 | INMA G03/176 | PI04/2018 | PI041436 | PI081151 | PI09/02311 | PI12/01890 | PI13/02429 | PI15/00118 | PI18/00909 | FIS-PI06/0867 | FIS-PI09/00090 | 1262C0010
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