Lysine-based non-cytotoxic ultrashort selfassembling peptides with antimicrobial activity
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Otros documentos de la autoría: OZBEK, NAGIHAN; Llorens, Eugenio; Vicedo, Begonya; Falomir, Eva; Escuder, Beatriu
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Título
Lysine-based non-cytotoxic ultrashort selfassembling peptides with antimicrobial activityFecha de publicación
2024Editor
Royal Society of ChemistryISSN
2046-2069Cita bibliográfica
ÖZBEK, Nagihan, et al. Lysine-based non-cytotoxic ultrashort self-assembling peptides with antimicrobial activity. RSC advances, 2024, vol. 14, núm 21, p. 15120-15128.Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
https://pubs.rsc.org/en/Content/ArticleLanding/2024/RA/D3RA08883AVersión
info:eu-repo/semantics/publishedVersionResumen
Peptide-based molecules and their hydrogels are useful materials for biomedical applications due to the reversible nature of their self-assembly as well as the diversity of nanostructures that can be created starting ... [+]
Peptide-based molecules and their hydrogels are useful materials for biomedical applications due to the reversible nature of their self-assembly as well as the diversity of nanostructures that can be created starting from low-molecular weight compounds. In this study, we have focused on comprehending the characteristics of fibrillar networks of L-lysine-based self-assembled dipeptide hydrogels with a focus on their antibacterial properties. For that purpose, L-lysine has been complemented with hydrophobic aromatic moieties coming from L-phenylalanine and benzyloxyxarbonyl N-capping. In addition, the peptide C-terminus is blocked with alkylamides of different chain lengths which introduces additional dispersive interactions and hydrophobicity. These materials were well characterized by transmission electron microscopy, scanning electron microscopy, wide-angle powder X-ray diffraction and oscillatory rheology. Finally, biocompatibility and antimicrobial tests were performed showing that these hydrogels are compatible with HEK 293 cells and present a remarkable antibacterial activity against both Gram positive (S. aureus) and Gram negative (E. coli) bacteria. [-]
Entidad financiadora
Ministerio de Ciencia, Innovación y Universidades | Agencia Estatal de Investigación | Universitat Jaume I | Generalitat Valenciana
Código del proyecto o subvención
PID2019-110892RB-I00 | UJI-B2020-21 | GRISOLIAP/2020/040
Proyecto de investigación
MCIN/AEI/10.13039/ 501100011033Derechos de acceso
info:eu-repo/semantics/openAccess
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Excepto si se señala otra cosa, la licencia del ítem se describe como: © 2024 The Author(s). Published by the Royal Society of Chemistry.
Open Access Article. Published on 08 May 2024. Downloaded on 6/12/2024 4:46:05 PM. This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.