Maternal occupational exposure to chemicals and child cognitive function
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INVESTIGACIONMetadatos
Título
Maternal occupational exposure to chemicals and child cognitive functionAutoría
Fecha de publicación
2022-05-16Editor
Springer NatureISSN
0031-3998; 1530-0447Cita bibliográfica
Ish, J., Symanski, E., Gimeno Ruiz de Porras, D., Casas, M., Delclos, G. L., Guxens, M., ... & Whitworth, K. W. (2022). Maternal occupational exposure to chemicals and child cognitive function. Pediatric research, 92(4), 1153-1160.Tipo de documento
info:eu-repo/semantics/articleVersión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
Background :
Limited data exist regarding child neurodevelopment in relation to maternal occupational exposure to endocrine-disrupting chemicals (EDCs).
Methods :
We included 1058 mother–child pairs from the ... [+]
Background :
Limited data exist regarding child neurodevelopment in relation to maternal occupational exposure to endocrine-disrupting chemicals (EDCs).
Methods :
We included 1058 mother–child pairs from the INfancia y Medio Ambiente (INMA) project (2003–2008). Using a job-exposure matrix, exposure probability scores for ten EDC groups were assigned to each mother based on her longest held job during pregnancy. At the child’s 5-year visit, the McCarthy Scales of Children’s Abilities was administered, yielding the general cognitive index and scales for specific cognitive domains. We analyzed region-specific associations between EDC exposures and each outcome separately using adjusted linear regression and combined region-specific effect estimates using random-effects meta-analyses.
Results :
Approximately 24% of women were exposed to at least one EDC group, but exposure to most individual EDC groups was low (<5%). Maternal organic solvent exposure was associated with lower quantitative scores among children (−5.8 points, 95% confidence interval: −11.0, −0.5). Though statistically non-significant, exposures to polycyclic aromatic hydrocarbons, phthalates, alkylphenolic compounds, and miscellaneous chemicals were associated with poorer offspring performance for most or all cognitive domains.
Conclusions :
This study found limited evidence for a role of maternal occupational EDC exposures on child cognition. Further research is needed to better characterize exposures among pregnant workers. [-]
Publicado en
Pediatric Research Vol. 92 (2022)Entidad financiadora
National Institutes of Health | National Institute of Environmental Health Sciences | Instituto de Salud Carlos III | Generalitat de Catalunya | Generalitat Valenciana | Department of Health of the Basque Government | Provincial Government of Gipuzkoa
Código del proyecto o subvención
R01ES028842 | Miguel Servet-FEDER CP11/00178, CP15/00025, CPII16/00051, CPII18/00018, CP16/00128 | FISABIO (UGP 15-230, UGP-15-244, UGP-15-249) | Red INMA G03/176, CB06/02/0041 | FIS-FEDER: PI03/1615, PI04/1509, PI04/1112, PI04/1931, PI05/1079, PI05/1052, PI06/0867, PI06/1213, PI07/0314, PI09/02647, PI11/01007, PI11/02591, PI11/02038, PI13/1944, PI13/2032, PI14/00891, PI14/01687, PI16/1288, PI17/00663, FIS-PI18/01142
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info:eu-repo/semantics/openAccess
info:eu-repo/semantics/openAccess
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