Trait anxiety is associated with attentional brain networks
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Title
Trait anxiety is associated with attentional brain networksAuthor (s)
Date
2024-03-15Publisher
Elsevier B.V.ISSN
0924-977XBibliographic citation
Víctor De la Peña-Arteaga, Pamela Chavarría-Elizondo, Asier Juaneda-Seguí, Ignacio Martínez-Zalacaín, Pedro Morgado, José Manuel Menchón, Maria Picó-Pérez, Miquel A. Fullana, Carles Soriano-Mas, Trait anxiety is associated with attentional brain networks, European Neuropsychopharmacology, Volume 83, 2024, Pages 19-26, ISSN 0924-977X, https://doi.org/10.1016/j.euroneuro.2024.02.013.Type
info:eu-repo/semantics/articlePublisher version
https://www.sciencedirect.com/science/article/pii/S0924977X24000488Version
info:eu-repo/semantics/publishedVersionSubject
Abstract
Trait anxiety is a well-established risk factor for anxiety and depressive disorders, yet its neural correlates are not clearly understood. In this study, we investigated the neural correlates of trait anxiety in a ... [+]
Trait anxiety is a well-established risk factor for anxiety and depressive disorders, yet its neural correlates are not clearly understood. In this study, we investigated the neural correlates of trait anxiety in a large sample (n = 179) of individuals who completed the trait and state versions of the State-Trait Anxiety Inventory and underwent resting-state functional magnetic resonance imaging. We used independent component analysis to characterize individual resting-state networks (RSNs), and multiple regression analyses to assess the relationship between trait anxiety and intrinsic connectivity. Trait anxiety was significantly associated with intrinsic connectivity in different regions of three RSNs (dorsal attention network, default mode network, and auditory network) when controlling for state anxiety. These RSNs primarily support attentional processes. Notably, when state anxiety was not controlled for, a different pattern of results emerged, highlighting the importance of considering this factor in assessing the neural correlates of trait anxiety. Our findings suggest that trait anxiety is uniquely associated with resting-state brain connectivity in networks mainly supporting attentional processes. Moreover, controlling for state anxiety is crucial when assessing the neural correlates of trait anxiety. These insights may help refine current neurobiological models of anxiety and identify potential targets for neurobiologically-based interventions. [-]
Is part of
European Neuropsychopharmacology, Volume 83, 2024.Funder Name
Agència de Gestió d'Ajuts Universitaris i de Recerca | PRTR | Departament de Salut, Generalitat de Catalunya | Horizon 2020 | European Commission | "la Caixa” Foundation
Project code
2017 SGR 1247 | JDC2022-048445-I, FI17/00294 | SLT006/17/249 | 714673 | MAZ/2021/11 | 100010434, LCF/BQ/IN17/11620071
Rights
© 2024 The Authors
info:eu-repo/semantics/openAccess
info:eu-repo/semantics/openAccess
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