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Some key parameters in contextual fear conditioning and extinction in adult rats
dc.contributor.author | Navarro Sánchez, Mónica | |
dc.contributor.author | Gil-Miravet, Isis | |
dc.contributor.author | Montero Caballero, Daniel | |
dc.contributor.author | Castillo-Gómez, Esther | |
dc.contributor.author | Gundlach, Andrew Lawrence | |
dc.contributor.author | Olucha-Bordonau, Francisco E | |
dc.date.accessioned | 2024-05-03T08:27:35Z | |
dc.date.available | 2024-05-03T08:27:35Z | |
dc.date.issued | 2024-03-28 | |
dc.identifier.citation | M. Navarro-Sánchez, I. Gil-Miravet, D. Montero-Caballero, E. Castillo-Gómez, A. L. Gundlach, F. E. Olucha-Bordonau, Some key parameters in contextual fear conditioning and extinction in adult rats, Behav. Brain Res. 462, (2024) 114874, https://doi.org/10.1016/j.bbr.2024.114874 | ca_CA |
dc.identifier.issn | 0166-4328 | |
dc.identifier.issn | 1872-7549 | |
dc.identifier.uri | http://hdl.handle.net/10234/207203 | |
dc.description.abstract | Contextual fear conditioning is a behavioral paradigm used to assess hippocampal-dependent memory in experimental animals. Perception of the context depends on activation of a distinct population of neurons in the hippocampus and in hippocampal-related areas that process discrete aspects of context perception. In the absence of any putatively associated cue, the context becomes the salient element that may warn of an upcoming aversive event; and in particular conditions, animals generalize this warning to any new or similar context. In this study we evaluated the effects of the number of sessions, the number of unconditioned stimuli per acquisition session and the distribution of extinction sessions to assess fear acquisition and extinction and determine under which conditions generalization occurred in adult, male rats. We observed that the organization and spacing of sessions were relevant factors in the acquisition and extinction of contextual fear memories. Extinction occurred with significantly greater robustness when sessions were spread over two days. Furthermore, results indicated that exposure to a single 0.3 mA, 0.5 s footshock in two different sessions could produce context-specific fear, while more acquisition sessions or more footshocks within a single session produced a generalization of the fear response to a new context. Notably, when generalization occurred, successive re-exposure to the generalized context produced extinction in a similar way to the paired exposure. Together, the present findings identify clear procedural and behavioral parameters amenable to neural systems analysis of three clinically relevant outcomes of contextual fear conditioning, i.e., memory acquisition, storage and extinction. | ca_CA |
dc.description.sponsorShip | Funding for open access charge: CRUE-Universitat Jaume I | |
dc.format.extent | 9 p. | ca_CA |
dc.format.mimetype | application/pdf | ca_CA |
dc.language.iso | eng | ca_CA |
dc.publisher | Elsevier | ca_CA |
dc.relation | Desarrollo de sistemas peptidérgicos relacionados con comportamiento social. la interacción relaxin3-oxitocina | ca_CA |
dc.relation.isPartOf | Behavioural Brain Research, 2024, vol. 462 | ca_CA |
dc.rights | Copyright © 2024 Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). | ca_CA |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | ca_CA |
dc.subject | acquisition | ca_CA |
dc.subject | associative learning | ca_CA |
dc.subject | context discrimination | ca_CA |
dc.subject | freezing | ca_CA |
dc.subject | generalization | ca_CA |
dc.subject | PTSD | ca_CA |
dc.title | Some key parameters in contextual fear conditioning and extinction in adult rats | ca_CA |
dc.type | info:eu-repo/semantics/article | ca_CA |
dc.identifier.doi | https://doi.org/10.1016/j.bbr.2024.114874 | |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | ca_CA |
dc.relation.publisherVersion | https://www.sciencedirect.com/science/article/pii/S0166432824000305 | ca_CA |
dc.description.sponsorship | This research was funded by the UJI predoctoral program PREDOC/2021/19 (MN-S), the UJI postdoctoral program POSDOC/2021/19 (IG-M); Fundación Alicia Koplowitz, Spain, grant number 19I436 (FEO-B, EC-G); the Spanish Ministerio de Ciencia, Innovación y Universidades, grant number RTI2018–095698-B-I00 (FEO-B, IG-M, EC-G); AICO Generalitat Valenciana, grant number AICO/2021/246 (EC-G, FEO-B), the Plan Nacional sobre Drogas of the Spanish Ministerio de Sanidad y Consumo grant number 2020I012 (FEO-B and EC-G) and UJI-B2019–54 (FEO-B). | |
dc.type.version | info:eu-repo/semantics/publishedVersion | ca_CA |
project.funder.identifier | http://dx.doi.org/10.13039/501100011033 | ca_CA |
project.funder.name | Ministerio de Ciencia, Innovación y Universidades | ca_CA |
project.funder.name | Generalitat Valenciana | ca_CA |
project.funder.name | Fundación Alicia Koplowitz | ca_CA |
project.funder.name | Ministerio de Sanidad y Consumo | ca_CA |
project.funder.name | Universitat Jaume I | ca_CA |
oaire.awardNumber | MICIU/ICTI2017-2020/RTI2018–095698-B-I00 | ca_CA |
oaire.awardNumber | AICO/2021/246 | ca_CA |
oaire.awardNumber | 19I436 | ca_CA |
oaire.awardNumber | 2020I012 | ca_CA |
oaire.awardNumber | PREDOC/2021/19 | ca_CA |
oaire.awardNumber | POSDOC/2021/19 | ca_CA |
oaire.awardNumber | UJI-B2019–54 | ca_CA |
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