Systemic analysis of metabolome reconfiguration in Arabidopsis after abiotic stressors uncovers metabolites that modulate defense against pathogens
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Título
Systemic analysis of metabolome reconfiguration in Arabidopsis after abiotic stressors uncovers metabolites that modulate defense against pathogensFecha de publicación
2023-07-04Editor
Cell Press, ElsevierCita bibliográfica
Garcia-Molina, A., & Pastor, V. (2024). Systemic analysis of metabolome reconfiguration in Arabidopsis after abiotic stressors uncovers metabolites that modulate defense against pathogens. Plant Communications, 5(1).Tipo de documento
info:eu-repo/semantics/articleVersión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
Understanding plant immune responses is complex because of the high interdependence among biological processes in homeostatic networks. Hence, the integration of environmental cues causes network rewiring that interferes ... [+]
Understanding plant immune responses is complex because of the high interdependence among biological processes in homeostatic networks. Hence, the integration of environmental cues causes network rewiring that interferes with defense responses. Similarly, plants retain molecular signatures configured under abiotic stress periods to rapidly respond to recurrent stress, and these can alter immunity. Metabolome changes imposed by abiotic stressors are persistent, although their impact on defense remains to be clarified. In this study, we profiled metabolomes of Arabidopsis plants under several abiotic stress treatments applied individually or simultaneously to capture temporal trajectories in metabolite composition during adverse conditions and recovery. Further systemic analysis was performed to address the relevance of metabolome changes and extract central features to be tested in planta. Our results demonstrate irreversibility in major fractions of metabolome changes as a general pattern in response to abiotic stress periods. Functional analysis of metabolomes and co-abundance networks points to convergence in the reconfiguration of organic acid and secondary metabolite metabolism. Arabidopsis mutant lines for components related to these metabolic pathways showed altered defense capacities against different pathogens. Collectively, our data suggest that sustained metabolome changes configured in adverse environments can act as modulators of immune responses and provide evidence for a new layer of regulation in plant defense. [-]
Publicado en
Plant Communications Volume 5, Issue 1, (January 2024)Entidad financiadora
Unió Europea | Ministerio de Ciencia, Innovación y Universidades | Ministerio de Ciencia e Innovación, Agencia Estatal de Investigación (AEI/10.13039/501100011033) | Generalitat de Catalunya
Código del proyecto o subvención
Marie Sklodowska-Curie grant 101028809 | RTI2018-094350-B-C33 | SEV-2015-0533 | CEX2019-000902-S
Título del proyecto o subvención
Horizon 2020 research and innovation programme | CERCA Programme
Derechos de acceso
info:eu-repo/semantics/openAccess
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