Small Extracellular Vesicles and Oxidative Pathophysiological Mechanisms in Retinal Degenerative Diseases
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Título
Small Extracellular Vesicles and Oxidative Pathophysiological Mechanisms in Retinal Degenerative DiseasesAutoría
Fecha de publicación
2024-01-28Editor
Multidisciplinary Digital Publishing Institute (MDPI)ISSN
1661-6596Cita bibliográfica
Romero, F.J.; Diaz-Llopis, M.; Romero-Gomez, M.I.; Miranda, M.; Romero-Wenz, R.; Sancho-Pelluz, J.; Romero, B.; Muriach, M.; Barcia, J.M. Small Extracellular Vesicles and Oxidative Pathophysiological Mechanisms in Retinal Degenerative Diseases. Int. J. Mol. Sci. 2024, 25, 1618. https://doi.org/10.3390/ijms25031618Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
https://www.mdpi.com/1422-0067/25/3/1618Versión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
This review focuses on the role of small extracellular vesicles in the pathophysiological mechanisms of retinal degenerative diseases. Many of these mechanisms are related to or modulated by the oxidative burden of ... [+]
This review focuses on the role of small extracellular vesicles in the pathophysiological mechanisms of retinal degenerative diseases. Many of these mechanisms are related to or modulated by the oxidative burden of retinal cells. It has been recently demonstrated that cellular communication in the retina involves extracellular vesicles and that their rate of release and cargo features might be affected by the cellular environment, and in some instances, they might also be mediated by autophagy. The fate of these vesicles is diverse: they could end up in circulation being used as markers, or target neighbor cells modulating gene and protein expression, or eventually, in angiogenesis. Neovascularization in the retina promotes vision loss in diseases such as diabetic retinopathy and age-related macular degeneration. The importance of micro RNAs, either as small extracellular vesicles’ cargo or free circulating, in the regulation of retinal angiogenesis is also discussed. [-]
Publicado en
International Journal of Molecular Sciences. 2024; 25(3)Entidad financiadora
Instituto de Salud Carlos III | Agencia Estatal de Investigación
Código del proyecto o subvención
PI21/00083 | PID2020-117875GB-I00/AEI/10.13039/501100011033
Derechos de acceso
© 2024 by the authors
info:eu-repo/semantics/openAccess
info:eu-repo/semantics/openAccess
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- MED_Articles [662]