Mapping gray and white matter volume abnormalities in earlyonset psychosis: an ENIGMA multicenter voxel-based morphometry study
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INVESTIGACIONMetadatos
Título
Mapping gray and white matter volume abnormalities in earlyonset psychosis: an ENIGMA multicenter voxel-based morphometry studyAutoría
Fecha de publicación
2024Editor
Springer NatureCita bibliográfica
Si, S., Bi, A., Yu, Z. et al. Mapping gray and white matter volume abnormalities in early-onset psychosis: an ENIGMA multicenter voxel-based morphometry study. Mol Psychiatry (2024). https://doi.org/10.1038/s41380-023-02343-1Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
https://www.nature.com/articles/s41380-023-02343-1Versión
info:eu-repo/semantics/publishedVersionResumen
INTRODUCTION: Regional gray matter (GM) alterations have been reported in early-onset psychosis (EOP, onset before age 18), but
previous studies have yielded conflicting results, likely due to small sample sizes and ... [+]
INTRODUCTION: Regional gray matter (GM) alterations have been reported in early-onset psychosis (EOP, onset before age 18), but
previous studies have yielded conflicting results, likely due to small sample sizes and the different brain regions examined. In this
study, we conducted a whole brain voxel-based morphometry (VBM) analysis in a large sample of individuals with EOP, using the
newly developed ENIGMA-VBM tool.
METHODS: 15 independent cohorts from the ENIGMA-EOP working group participated in the study. The overall sample comprised
T1-weighted MRI data from 482 individuals with EOP and 469 healthy controls. Each site performed the VBM analysis locally using
the standardized ENIGMA-VBM tool. Statistical parametric T-maps were generated from each cohort and meta-analyzed to reveal
voxel-wise differences between EOP and healthy controls as well as the individual-based association between GM volume and age
of onset, chlorpromazine (CPZ) equivalent dose, and other clinical variables.
RESULTS: Compared with healthy controls, individuals with EOP showed widespread lower GM volume encompassing most of the
cortex, with the most marked effect in the left median cingulate (Hedges’ g = 0.55, p = 0.001 corrected), as well as small clusters of
lower white matter (WM), whereas no regional GM or WM volumes were higher in EOP. Lower GM volume in the cerebellum,
thalamus and left inferior parietal gyrus was associated with older age of onset. Deficits in GM in the left inferior frontal gyrus, right
insula, right precentral gyrus and right superior frontal gyrus were also associated with higher CPZ equivalent doses.
CONCLUSION: EOP is associated with widespread reductions in cortical GM volume, while WM is affected to a smaller extent. GM
volume alterations are associated with age of onset and CPZ equivalent dose but these effects are small compared to case-control
differences. Mapping anatomical abnormalities in EOP may lead to a better understanding of the role of psychosis in brain
development during childhood and adolescence. [-]
Publicado en
Molecular Psychiatry (2024)Entidad financiadora
Gobierno de la Comunidad de Madrid | European Union (EU) | European Union H2020 Program under the Innovative Medicines Initiative 2 Joint Undertaking | NextGenerationEU/PRTR | Agencia Estatal de Investigación | European Commission
Código del proyecto o subvención
S2022/BMD-7216 | 1978-1998 | S2022/BMD-7216 (AGES 3-CM) | 2004-259 | 2006-186 | RYC2021-031228-I | MCIN/AEI/10.13039/50110 0011033 | JR19/00024 | PI02100330 | PI18/00976 | PI19/01024 | PI20/00654 | PI20/00721 | PMP21/00051
Proyecto de investigación
info:eu-repo/grantAgreement/EC/H2020/101034377info:eu-repo/grantAgreement/EC/H2020/777394
Derechos de acceso
info:eu-repo/semantics/openAccess
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